NFAT Signaling: Choreographing the Social Lives of Cells
Gerald R. Crabtree,Eric N. Olson +1 more
TLDR
Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc proteins into the nucleus, where they cooperate with other proteins to form complexes on DNA.About:
This article is published in Cell.The article was published on 2002-04-19 and is currently open access. It has received 1335 citations till now. The article focuses on the topics: NFATC Transcription Factors & NFAT.read more
Citations
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Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Hiroshi Takayanagi,Sunhwa Kim,Takako Koga,Takako Koga,Hiroshi Nishina,Masashi Isshiki,Hiroki Yoshida,Hiroki Yoshida,Akio Saiura,Miho Isobe,Miho Isobe,Taeko Yokochi,Jun-ichiro Inoue,Erwin F. Wagner,Tak W. Mak,Tatsuhiko Kodama,Tadatsugu Taniguchi +16 more
TL;DR: RANKL selectively induces NFATc1 expression via TRAF6 and c-Fos signaling pathways, and may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL.
Journal ArticleDOI
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Stefan Feske,Yousang Gwack,Murali Prakriya,Sonal Srikanth,Sven Holger Puppel,Bogdan Tanasa,Patrick G. Hogan,Richard S. Lewis,Mark J. Daly,Mark J. Daly,Anjana Rao +10 more
TL;DR: It is proposed that Orai1 is an essential component or regulator of the CRAC channel complex, which contains four putative transmembrane segments and is based on a novel protein that was identified in SCID patients.
Journal ArticleDOI
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
Jen Liou,Man Lyang Kim,Won Do Heo,Joshua T. Jones,Jason W. Myers,James E. Ferrell,Tobias Meyer +6 more
TL;DR: This study suggests that STIM proteins function as Ca(2+) store sensors in the signaling pathway connecting Ca(1+)-store-depletion-mediated Ca( 2+) influx, and suggests that this mutant failed to respond to store depletion.
Journal ArticleDOI
Transcriptional regulation by calcium, calcineurin, and NFAT
TL;DR: The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family, and it is clear that NFAT activates transcription of a large number of genes during an effective immune response.
Journal ArticleDOI
FGF23 induces left ventricular hypertrophy
Christian Faul,Ansel P. Amaral,Behzad N. Oskouei,Ming Chang Hu,Alexis Sloan,Tamara Isakova,Orlando M. Gutiérrez,Robier Aguillon-Prada,Joy Lincoln,Joshua M. Hare,Peter Mundel,Azorides R. Morales,Julia J. Scialla,Michael J. Fischer,Michael J. Fischer,Elsayed Z. Soliman,Jing Chen,Alan S. Go,Sylvia E. Rosas,Lisa Nessel,Raymond R. Townsend,Harold I. Feldman,Martin St. John Sutton,Akinlolu O. Ojo,Crystal A. Gadegbeku,Giovana Seno Di Marco,Stefan Reuter,Dominik Kentrup,Klaus Tiemann,Marcus Brand,Joseph A. Hill,Orson W. Moe,Makoto Kuro-o,John W. Kusek,Martin G. Keane,Myles Wolf +35 more
TL;DR: It is reported that elevated FGF23 levels are independently associated with LVH in a large, racially diverse CKD cohort and suggested that chronically elevated F GF23 levels contribute directly to high rates of LVH and mortality in individuals with CKD.
References
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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Jun Liu,Jesse D. Farmer,Willam S. Lane,Jeffrey S. Friedman,Irving L. Weissman,Stuart L. Schreiber +5 more
TL;DR: The results suggest that calcineurin is involved in a common step associated with T cell receptor and IgE receptor signaling pathways and that cyclophilin and FKBP mediate the actions of CsA and Fk506 by forming drug-dependent complexes with and altering the activity of calcineURin-calmodulin.
Journal ArticleDOI
Vascular-specific growth factors and blood vessel formation
George D. Yancopoulos,Samuel Davis,Nicholas W. Gale,John S. Rudge,Stanley J. Wiegand,Jocelyn Holash +5 more
TL;DR: New findings in newly discovered vascular growth factors demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.
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A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Jeffery D. Molkentin,Jeffery D. Molkentin,Jianrong Lu,Christopher L. Antos,Bruce E. Markham,James A. Richardson,Jeffrey Robbins,Stephen R. Grant,Eric N. Olson +8 more
TL;DR: It is shown that cardiac hypertrophy is induced by the calcium-dependent phosphatase calcineurin, which dephosphorylates the transcription factor NF-AT3, enabling it to translocate to the nucleus.
Journal ArticleDOI
Calcium - a life and death signal
TL;DR: This research investigates how the calcium ion regulates cell birth, life and death, and how it regulates so many different cellular processes in the human body.
Journal ArticleDOI
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
TL;DR: It is reported here that overexpression of calcineurin in Jurkat cells renders them more resistant to the effects of CsA and FK506 and augments both NFAT- and NFIL2A-dependent transcription.