Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity
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TLDR
The data suggest that the impact of elevated FFA on sphingolipids reaches beyond ceramides and de novo sphingosine-1-phosphate synthesis and identifies PAL as a novel regulatory stimulus for SK1.About:
This article is published in Journal of Lipid Research.The article was published on 2009-09-01 and is currently open access. It has received 81 citations till now. The article focuses on the topics: Sphingosine kinase & Sphingosine-1-phosphate.read more
Citations
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Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
TL;DR: A major goal of the review is to help the reader more easily grasp the metabolic interrelationships that account for the tens of thousands of molecular subspecies that appear in nature, with a focus on mammals.
Journal ArticleDOI
Ceramides – Lipotoxic Inducers of Metabolic Disorders
TL;DR: The need to further decipher the full array of benefits elicited by ceramide depletion is highlighted, suggesting that inhibiting ceramide biosynthesis or catalyzing ceramide degradation in rodents ameliorates many metabolic disorders including diabetes, cardiomyopathy, insulin resistance, atherosclerosis, and steatohepatitis.
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Metabolites as regulators of insulin sensitivity and metabolism
TL;DR: A comprehensive understanding of the metabolic adaptations involved in insulin resistance may enable the identification of novel targets for improving insulin sensitivity and preventing, and treating, T2DM.
Journal ArticleDOI
Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
Amanda R. Martins,Renato Tadeu Nachbar,Renata Gorjão,Marco Aurélio Ramirez Vinolo,William T. Festuccia,Rafael Herling Lambertucci,Maria Fernanda Cury-Boaventura,Leonardo R. Silveira,Rui Curi,Sandro M. Hirabara +9 more
TL;DR: Experimental evidence supporting the involvement of Randle cycle, oxidative stress, inflammation and mitochondrial dysfunction in the development of skeletal muscle insulin resistance induced by saturated fatty acids are reviewed and an integrative model placing mitochondrial dysfunction as an important and common factor to the other mechanisms is proposed.
Journal ArticleDOI
Lipotoxicity disrupts incretin-regulated human β cell connectivity
David J. Hodson,Ryan K. Mitchell,Elisa A. Bellomo,Gao Sun,Laurent Vinet,Paolo Meda,Daliang Li,Wen Hong Li,Marco Bugliani,Piero Marchetti,Domenico Bosco,Lorenzo Piemonti,Paul Johnson,Stephen J. Hughes,Guy A. Rutter +14 more
TL;DR: It is demonstrated that β cell connectedness is an inherent property of human islets that is likely to influence incretin-potentiated insulin secretion and may be perturbed by diabetogenic insults to disrupt glucose homeostasis in humans.
References
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Principles of bioactive lipid signalling: lessons from sphingolipids
TL;DR: An understanding of the complex pathways of sphingolipid metabolism and the mechanisms that regulate lipid generation and lipid action is required to understand the mechanisms of cell growth, death, senescence, adhesion, migration, inflammation, angiogenesis and intracellular trafficking.
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Advances in male contraception.
TL;DR: Great strides have been made in understanding male reproductive physiology; the combined efforts of scientists, clinicians, industry and governmental funding agencies could make an effective, reversible, male contraceptive an option for family planning over the next decade.
Journal ArticleDOI
Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance
William L. Holland,Joseph T. Brozinick,Liping Wang,Eric D. Hawkins,Katherine M. Sargent,Yanqi Liu,Krishna K. Narra,Kyle L. Hoehn,Trina A. Knotts,Angela M. Siesky,Don H. Nelson,Sotirios K. Karathanasis,Greg K Fontenot,Morris J. Birnbaum,Scott A. Summers +14 more
TL;DR: It is demonstrated that the sphingolipid ceramide is a common molecular intermediate linking several different pathological metabolic stresses to the induction of insulin resistance, and enzymes required for ceramide synthesis are identified as therapeutic targets for combating insulin resistance caused by nutrient excess or glucocorticoid therapy.
Journal ArticleDOI
Ceramides in insulin resistance and lipotoxicity.
TL;DR: The contribution of ceramides in the development of insulin resistance and the complications associated with metabolic diseases is evaluated.
Journal ArticleDOI
Diet-induced obese mice develop peripheral, but not central, resistance to leptin.
M. van Heek,Douglas S Compton,R P Tedesco,Ahmad Fawzi,M. P. Graziano,Edmund J. Sybertz,Catherine D. Strader,H. Davis +7 more
TL;DR: It is demonstrated that, in a diet-induced obesity model, mice exhibit resistance to peripherally administered leptin, while retaining sensitivity to centrally administered leptin.
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