Journal ArticleDOI
Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models.
Adam Stewart,Nadine Wu,Jonathan Cachat,Peter C. Hart,Siddharth Gaikwad,Keith Wong,Eli Utterback,Thomas Gilder,Evan J. Kyzar,Alan Newman,Dillon Carlos,Katie Chang,Molly Hook,Catherine Rhymes,Michael Caffery,Mitchell Greenberg,James E. Zadina,Allan V. Kalueff +17 more
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TLDR
Recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents support this species as a useful model for neurobehavioral and psychopharmacological research.Abstract:
Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.read more
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Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond
Allan V. Kalueff,Michael Gebhardt,Adam Stewart,Adam Stewart,Jonathan Cachat,Mallorie Brimmer,Jonathan S Chawla,Cassandra Craddock,Evan J. Kyzar,Andrew Roth,Samuel Landsman,Siddharth Gaikwad,Kyle Robinson,Erik Baatrup,Keith B. Tierney,Angela L. Shamchuk,William H. J. Norton,Noam Miller,Teresa Nicolson,Oliver Braubach,Charles P. Gilman,Julian Pittman,Denis B. Rosemberg,Robert Gerlai,David J. Echevarria,Elisabeth Lamb,Stephan C.F. Neuhauss,Wei Weng,Laure Bally-Cuif,Henning Schneider +29 more
TL;DR: A detailed catalog of zebrafish behaviors that covers both larval and adult models is developed, representing a beginning of creating a more comprehensive ethogram ofZebrafish behavior, which will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebra fish neurobehavioral paradigms in their research.
Journal ArticleDOI
Zebrafish as an emerging model for studying complex brain disorders.
TL;DR: It is argued that zebrafish models of complex brain disorders and drug-induced conditions are a rapidly emerging critical field in translational neuroscience and pharmacology research.
Journal ArticleDOI
Zebrafish models for translational neuroscience research: from tank to bedside.
TL;DR: The Zebrafish is emerging as a new important species for studying mechanisms of brain function and dysfunction and the potential of zebrafish models in behavioral phenomics and high-throughput genetic/small molecule screening, which is critical for CNS drug discovery and identifying novel candidate genes.
Journal ArticleDOI
Modeling anxiety using adult zebrafish: A conceptual review
TL;DR: This work evaluates established and novel approaches to uncover the molecular substrates, genetic pathways and neural circuits of anxiety using adult zebrafish, and provides a conceptual framework for the wider application of zebra fish and other aquatic models in anxiety research.
Journal ArticleDOI
Measuring thigmotaxis in larval zebrafish.
TL;DR: It is suggested that stimuli such as exposure to sudden darkness could be used proficiently to trigger the expression of anxiety-like behaviors in laboratory settings and is constituting a valuable tool for stress and central nervous system research as well as for preclinical drug screening and discovery.
References
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Neil McNaughton,Philip J. Corr +1 more
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Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish
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Journal ArticleDOI
Neurocognitive mechanisms of anxiety: an integrative account
Sonia J. Bishop,Sonia J. Bishop +1 more
TL;DR: Neuroimaging studies of conditioned fear, attention to threat and interpretation of emotionally ambiguous stimuli indicate common amygdala-prefrontal circuitry underlying these processes, and suggest that the balance of activity within this circuitry is altered in anxiety, creating a bias towards threat-related responses.
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Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation
Jason Rihel,David A. Prober,Anthony C. Arvanites,Kelvin Lam,Steven Zimmerman,Sumin Jang,Stephen J. Haggarty,Stephen J. Haggarty,David Kokel,Lee L. Rubin,Randall T. Peterson,Randall T. Peterson,Alexander F. Schier +12 more
TL;DR: The development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish are reported and it is found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors.
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