Posttraining systemic administration of the histone deacetylase inhibitor sodium butyrate ameliorates aging-related memory decline in rats
Gustavo Kellermann Reolon,Natasha Maurmann,Natasha Maurmann,Aline Werenicz,Vanessa Athaíde Garcia,Nadja Schröder,Marcelo A. Wood,Rafael Roesler +7 more
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The results indicate that HDACis can ameliorate aging-related memory impairments by influencing the early consolidation phase of memory formation.About:
This article is published in Behavioural Brain Research.The article was published on 2011-08-01 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Sodium butyrate & Histone deacetylase inhibitor.read more
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Histone acetylation: molecular mnemonics on the chromatin
TL;DR: As histone acetylation and cognitive functions can be pharmacologically restored by histone deacetylase inhibitors, this epigenetic modification might constitute a molecular memory aid on the chromatin and, by extension, a new template for therapeutic interventions against cognitive frailty.
Book ChapterDOI
Neuropeptides and the microbiota-gut-brain axis.
Peter Holzer,Aitak Farzi +1 more
TL;DR: Although the impact of neuropeptides on the interaction between the gut microbiota and brain awaits to be analysed, biologically active peptides are likely to emerge as neural and endocrine messengers in orchestrating the microbiota-gut-brain axis in health and disease.
Journal ArticleDOI
Epigenetics of stress adaptations in the brain.
TL;DR: It is concluded that specific epigenetic mechanisms in the CNS are involved in the stress response, including genome-wide epigenetic changes of DNA methylation and particular genes involved in epigenetic responses that participate in the brain response to chronic psychogenic stressors.
Journal ArticleDOI
Neurocognitive Aging and the Hippocampus across Species
TL;DR: This review surveys convergent data from animal and human studies that have contributed significantly to understanding of the brain-behavior relationships in the hippocampal network, particularly in the aging brain.
Journal ArticleDOI
Increasing histone acetylation in the hippocampus-infralimbic network enhances fear extinction.
TL;DR: The studies show that the memory modulating ability of drugs that enhance acetylation is sensitive to a variety of behavioral and molecular conditions.
References
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Journal ArticleDOI
Regulation of histone acetylation during memory formation in the hippocampus.
Jonathan M. Levenson,Kenneth J. O’Riordan,Karen D. Brown,Mimi A. Trinh,David L. Molfese,J. David Sweatt +5 more
TL;DR: Results indicate that histone-associated heterochromatin undergoes changes in structure during the formation of long term memory, which enhances a cellular process thought to underlie longterm memory formation, hippocampal long term potentiation, and memory formation itself.
Journal ArticleDOI
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.
Juan Marcos Alarcon,Gaël Malleret,Khalid Touzani,Svetlana Vronskaya,Shunsuke Ishii,Eric R. Kandel,Eric R. Kandel,Angel Barco +7 more
TL;DR: Some of the cognitive and physiological deficits observed on RTS are not simply due to the reduction of CBP during development but may also result from the continued requirement throughout life for both the CREB co-activation and the histone acetylation function of CBp.
Journal ArticleDOI
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Shahaf Peleg,Farahnaz Sananbenesi,Athanasios Zovoilis,Susanne Burkhardt,Sanaz Bahari-Javan,Roberto Carlos Agis-Balboa,Perla Cota,Jessica Wittnam,Andreas Gogol-Doering,Lennart Opitz,Gabriella Salinas-Riester,Markus Dettenhofer,Hui Kang,Laurent Farinelli,Wei Chen,Andre Fischer +15 more
TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.
Journal ArticleDOI
Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation
Christopher G. Vecsey,Joshua D. Hawk,K. Matthew Lattal,Joel M. Stein,Sara A. Fabian,Michelle A. Attner,Sara M. Cabrera,Conor B. McDonough,Paul K. Brindle,Ted Abel,Marcelo A. Wood +10 more
TL;DR: It is shown that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by the transcription factor cAMP response element-bindingprotein (CREB) and the recruitment of the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CBP) via the CREB -binding domain of CBP.
Journal ArticleDOI
Epigenetic mechanisms in memory formation
TL;DR: Neurobiologists have only recently begun to investigate the possible roles of epigenetic mechanisms in behaviour, physiology and neuropathology, and relevant data from the few extant neurobiology-related studies have already indicated a theme — epigenetic mechanism probably have an important role in synaptic plasticity and memory formation.