Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
Citations
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Journal ArticleDOI
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.
Marom Bikson,Pnina Grossman,Chris Thomas,Adantchede L. Zannou,Jimmy Jiang,Tatheer Adnan,Antonios P. Mourdoukoutas,Greg Kronberg,Dennis Q. Truong,Paulo S. Boggio,Andre R. Brunoni,Leigh Charvet,Felipe Fregni,Brita Fritsch,Bernadette T. Gillick,Roy H. Hamilton,Benjamin M. Hampstead,Ryan Jankord,Adam Kirton,Helena Knotkova,David Liebetanz,Anli Liu,Colleen Loo,Michael A. Nitsche,Janine Reis,Janine Reis,Jessica D. Richardson,Alexander Rotenberg,Peter E. Turkeltaub,Adam J. Woods +29 more
TL;DR: Evidence from relevant animal models indicates that brain injury by Direct Current Stimulation (DCS) occurs at predicted brain current densities that are over an order of magnitude above those produced by conventional tDCS.
Journal ArticleDOI
How does hormesis impact biology, toxicology, and medicine?
TL;DR: A working compartmentalization of hormesis is established into ten categories that provide an integrated understanding of the biological meaning and applications of horm Genesis to aid in designing and interpreting future studies.
Journal Article
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: Treatment with rhEPO significantly improved functional recovery, along with increases in density of cerebral microvessels at the stroke boundary and numbers of BrdU, doublecortin, and nestin immunoreactive cells in the SVZ.
Journal ArticleDOI
Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks
TL;DR: The present analysis reveals that hormetic biphasic dose responses were associated with both the conditioning process and the protective effects elicited following the challenging dose, indicating that the biological/biomedical effects induced by conditioning represent a specific type of hormetic dose response and thereby contribute significantly to a generalization of the hormetic concept.
Journal ArticleDOI
Mechanisms and Effects of Transcranial Direct Current Stimulation.
James Giordano,Marom Bikson,Emily S. Kappenman,Vincent P. Clark,H. Branch Coslett,Michael R. Hamblin,Roy H. Hamilton,Ryan Jankord,Walter J. Kozumbo,R. Andrew McKinley,Michael A. Nitsche,J. Patrick Reilly,Jessica D. Richardson,Rachel Wurzman,Edward J. Calabrese +14 more
TL;DR: The most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research were discussed at a recent meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine as mentioned in this paper.
References
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Journal ArticleDOI
Cardioprotection associated with preconditioning in the anesthetized ferret.
TL;DR: It is concluded in the ferret that the threshold for PC is less than in either the rat, rabbit, or dog: unlike the dog and pig, the beneficial effects of PC are reduced and lost if sustained coronary occlusion is maintained for a period of 75-min or longer; and last, a role in PC for both ATP-sensitive potassium channels and adenosine A1 receptors can be demonstrated.
Journal ArticleDOI
Protective effect of diazoxide against antimycin A-induced mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.
TL;DR: Diazoxide restored mitochondrial membrane potential dissipation, inactivation of complex IV, ATP loss, and intracellular calcium elevation that was induced by AMA treatment, and prevented cell death, suggesting that diazoxide may be useful to protect mitochondria from a burst of oxidative stress.
Journal ArticleDOI
Adaptive response to ionizing radiation induced by low dose of gamma ray in human hepatoma cell lines.
Jinsil Seong,Gwi Eon Kim +1 more
TL;DR: Prior exposure to 1 cGy of gamma rays reduces the number of chromatid breaks induced by subsequent higher doses of gamma radiation, suggesting that the adaptive response can be observed in human hepatoma cell lines, which is suggested through this study.
Journal ArticleDOI
Taurine-like GABA aminotransferase inhibitors prevent rabbit brain slices against oxygen–glucose deprivation-induced damage
TL;DR: The present investigation explored the neuroprotection provided by GABA, Vigabatrin (VIGA) and taurine analogues in the course of oxygen–glucose deprivation and reperfusion induced damage of rabbit brain slices and suggested hormetic (“U-shaped”) effects.
Journal ArticleDOI
Preconditioning with acute and chronic lithium administration reduces ischemia/reperfusion injury mediated by cyclooxygenase not nitric oxide synthase pathway in isolated rat heart.
TL;DR: It is demonstrated that preconditioning with acute and/or chronic lithium administration improves recovery of the ventricular function and reduces infarct size via cyclooxygenase (COX) pathway in isolated rat heart.
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