Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
Citations
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Journal ArticleDOI
Ferulic acid and hormesis: Biomedical and environmental implications.
TL;DR: In this article, the capacity of ferulic acid to induce hormetic dose responses in biological systems was evaluated. But the authors focused on neuroprotective effects, with particular focus on neuro-protective effect.
Book ChapterDOI
Safety of Transcranial Direct Current Stimulation
TL;DR: The data summarized in this chapter support the conclusion reached by prior review that there is no evidence suggesting that conventional tDCS protocols, as commonly implemented in either healthy subjects or patient populations in clinical trials, increase risk of serious adverse events.
Journal ArticleDOI
Lysosomes, Autophagy, and Hormesis in Cell Physiology, Pathology, and Age-Related Disease
TL;DR: The search is on the find inhibitors that can induce hormetic responses that may be suitable for treating many diseases, including many cancers, type 2 diabetes, and age-related neurodegenerative conditions.
Journal ArticleDOI
Antibiotics induced alterations in cell density, photosynthesis, microcystin synthesis and proteomic expression of Microcystis aeruginosa during CuSO4 treatment.
Yunhan Jiang,Ying Liu,Jian Zhang +2 more
TL;DR: Preventative application of CuSO4 to a low density of M. aeruginosa effectively prevented the formation of bloom at low CuSO 4 doses, which is a possible route for eliminating the negative effects ofCuSO4 algaecide in aquatic environments.
Journal ArticleDOI
Heat Acclimation-Mediated Cross-Tolerance: Origins in within-Life Epigenetics?
TL;DR: The link between in vivo physiological evidence and the associated cellular and molecular mechanisms leading to HACT and its difference from short-acting cross-tolerance strategies will be discussed.
References
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Journal ArticleDOI
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
TL;DR: The multiple anginal episodes that often precede myocardial infarction in man may delay cell death after coronary occlusion, and thereby allow for greater salvage of myocardium through reperfusion therapy, which is proposed to protect the heart from a subsequent sustained ischemic insult.
Journal ArticleDOI
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Anna-Leena Sirén,Maddalena Fratelli,Michael Brines,Christoph G. Goemans,Simona Casagrande,Piotr Lewczuk,Sonja Keenan,Christoph H. Gleiter,Claudio Pasquali,Annalisa Capobianco,Tiziana Mennini,Rolf Heumann,Anthony Cerami,Hannelore Ehrenreich,Pietro Ghezzi +14 more
TL;DR: Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well.
Journal ArticleDOI
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
John W. Elrod,John W. Calvert,Joanna Morrison,Jeannette E. Doeller,David W. Kraus,Ling Tao,Xiangying Jiao,Rosario Scalia,Levente Kiss,Csaba Szabó,Hideo Kimura,Chi Wing Chow,David J. Lefer +12 more
TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.
Journal ArticleDOI
Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
TL;DR: When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberration induced by [3 H]thcyidine and x-ray separately.
Journal ArticleDOI
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: The data suggest that EPO-increased VEGF and BDNF may be involved in angiogenesis and neurogenesis, which could contribute to functional recovery.
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