Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
Citations
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Journal ArticleDOI
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.
Marom Bikson,Pnina Grossman,Chris Thomas,Adantchede L. Zannou,Jimmy Jiang,Tatheer Adnan,Antonios P. Mourdoukoutas,Greg Kronberg,Dennis Q. Truong,Paulo S. Boggio,Andre R. Brunoni,Leigh Charvet,Felipe Fregni,Brita Fritsch,Bernadette T. Gillick,Roy H. Hamilton,Benjamin M. Hampstead,Ryan Jankord,Adam Kirton,Helena Knotkova,David Liebetanz,Anli Liu,Colleen Loo,Michael A. Nitsche,Janine Reis,Janine Reis,Jessica D. Richardson,Alexander Rotenberg,Peter E. Turkeltaub,Adam J. Woods +29 more
TL;DR: Evidence from relevant animal models indicates that brain injury by Direct Current Stimulation (DCS) occurs at predicted brain current densities that are over an order of magnitude above those produced by conventional tDCS.
Journal ArticleDOI
How does hormesis impact biology, toxicology, and medicine?
TL;DR: A working compartmentalization of hormesis is established into ten categories that provide an integrated understanding of the biological meaning and applications of horm Genesis to aid in designing and interpreting future studies.
Journal Article
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: Treatment with rhEPO significantly improved functional recovery, along with increases in density of cerebral microvessels at the stroke boundary and numbers of BrdU, doublecortin, and nestin immunoreactive cells in the SVZ.
Journal ArticleDOI
Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks
TL;DR: The present analysis reveals that hormetic biphasic dose responses were associated with both the conditioning process and the protective effects elicited following the challenging dose, indicating that the biological/biomedical effects induced by conditioning represent a specific type of hormetic dose response and thereby contribute significantly to a generalization of the hormetic concept.
Journal ArticleDOI
Mechanisms and Effects of Transcranial Direct Current Stimulation.
James Giordano,Marom Bikson,Emily S. Kappenman,Vincent P. Clark,H. Branch Coslett,Michael R. Hamblin,Roy H. Hamilton,Ryan Jankord,Walter J. Kozumbo,R. Andrew McKinley,Michael A. Nitsche,J. Patrick Reilly,Jessica D. Richardson,Rachel Wurzman,Edward J. Calabrese +14 more
TL;DR: The most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research were discussed at a recent meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine as mentioned in this paper.
References
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Journal ArticleDOI
Protective effects of ginsenoside Rd on PC12 cells against hydrogen peroxide.
TL;DR: It is suggested that ginsenoside Rd may be considered a potential antioxidant agent and should encourage further research in neurodegenerative diseases to explore the potential neuroprotective effects of ginsene Rd.
Journal ArticleDOI
Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK.
TL;DR: In conclusion pioglitazone induced significant protection against ischemia/reperfusion injury when administered prior to ischemIA, and appears to involve PI3K and P42/44MAPK.
Journal ArticleDOI
Ischemic preconditioning and clinical scenarios
TL;DR: IPC, RIPC, and IPC mimetics have the potential to be therapeutic in various clinical scenarios and further understanding of IPC-induced neuroprotection pathways and utilization of clinically relevant animal models are necessary to increase the translational potential of I PC in the near future.
Journal ArticleDOI
A proteasomal stress response: pre‐treatment with proteasome inhibitors increases proteasome activity and reduces neuronal vulnerability to oxidative injury
Chul Sang Lee,Lee Y. Tee,Timothy Warmke,Anant Vinjamoori,Ai Li Cai,Anne M. Fagan,B. Joy Snider +6 more
TL;DR: Findings support a model in which sublethal proteasome inhibition induces neurons to increase proteasomesome activity and promotes resistance to oxidative injury and suggests that enhancement of prote asome activity is a potential therapeutic target for diseases in which oxidative stress has been implicated.
Journal ArticleDOI
Clinical Applications of Remote Ischemic Preconditioning
TL;DR: The experimental and clinical trial data underpinning one of these “conditioning” strategies, the phenomenon of remote ischemic preconditioning, is summarised.
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