Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
Citations
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Cytotoxicity models of Huntington's disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies.
Edward J. Calabrese,Tarun N. Bhatia,Vittorio Calabrese,Gaurav Dhawan,James Giordano,Yannic N. Hanekamp,Rachna Kapoor,Walter J. Kozumbo,Rehana K. Leak +8 more
TL;DR: In vivo cytotoxicity models of Huntington's disease (HD) are assessed and not a single of the 150 agents that successfully delayed onset and progression of HD in the experimental models has been successfully translated to the treatment of humans in a clinical setting.
Journal ArticleDOI
Xenohormesis underlyes the anti-aging and healthy properties of olive polyphenols
Monica Bucciantini,Manuela Leri,Maria Scuto,Maria Laura Ontario,Angela Trovato Salinaro,Edward J. Calabrese,Vittorio Calabrese,Massimo Stefani +7 more
TL;DR: In this article , a comprehensive and foundational mechanistic framework of hormesis that establishes its centrality in medicine and public health is applied to the assessment of olive polyphenols with respect to their capacity to slow the onset and reduce the magnitude of a wide range of age-related disorders and neurodegenerative diseases, including Alzheimer's Disease and Parkinson's Disease.
Journal ArticleDOI
Two decades (1998–2018) of research Progress on Hormesis: advancing biological understanding and enabling novel applications
TL;DR: It is argued that conducting research on mechanisms that actuate and regulate the stimulatory response features of hormesis will provide the knowledge needed to develop potentially transformational applications aimed at protecting and enhancing biological resiliency as well as treating/curing a multitude of diverse medical conditions.
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Thresholds for carcinogens.
TL;DR: In this article, an integrated toxicological analysis is conducted to reconsider an alternative and once-promising approach, tumor latency, for estimating carcinogen-induced cancer risks at low doses.
Journal ArticleDOI
Hormesis and neural stem cells
TL;DR: In this paper , a detailed identification and assessment of hormetic dose responses in neural stem cells (NSCs) as identified in a number of animal models and human tissues, with particular emphasis on cell proliferation and differentiation.
References
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Journal ArticleDOI
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
TL;DR: The multiple anginal episodes that often precede myocardial infarction in man may delay cell death after coronary occlusion, and thereby allow for greater salvage of myocardium through reperfusion therapy, which is proposed to protect the heart from a subsequent sustained ischemic insult.
Journal ArticleDOI
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Anna-Leena Sirén,Maddalena Fratelli,Michael Brines,Christoph G. Goemans,Simona Casagrande,Piotr Lewczuk,Sonja Keenan,Christoph H. Gleiter,Claudio Pasquali,Annalisa Capobianco,Tiziana Mennini,Rolf Heumann,Anthony Cerami,Hannelore Ehrenreich,Pietro Ghezzi +14 more
TL;DR: Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well.
Journal ArticleDOI
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
John W. Elrod,John W. Calvert,Joanna Morrison,Jeannette E. Doeller,David W. Kraus,Ling Tao,Xiangying Jiao,Rosario Scalia,Levente Kiss,Csaba Szabó,Hideo Kimura,Chi Wing Chow,David J. Lefer +12 more
TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.
Journal ArticleDOI
Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
TL;DR: When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberration induced by [3 H]thcyidine and x-ray separately.
Journal ArticleDOI
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: The data suggest that EPO-increased VEGF and BDNF may be involved in angiogenesis and neurogenesis, which could contribute to functional recovery.
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