Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
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Journal ArticleDOI
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.
Marom Bikson,Pnina Grossman,Chris Thomas,Adantchede L. Zannou,Jimmy Jiang,Tatheer Adnan,Antonios P. Mourdoukoutas,Greg Kronberg,Dennis Q. Truong,Paulo S. Boggio,Andre R. Brunoni,Leigh Charvet,Felipe Fregni,Brita Fritsch,Bernadette T. Gillick,Roy H. Hamilton,Benjamin M. Hampstead,Ryan Jankord,Adam Kirton,Helena Knotkova,David Liebetanz,Anli Liu,Colleen Loo,Michael A. Nitsche,Janine Reis,Janine Reis,Jessica D. Richardson,Alexander Rotenberg,Peter E. Turkeltaub,Adam J. Woods +29 more
TL;DR: Evidence from relevant animal models indicates that brain injury by Direct Current Stimulation (DCS) occurs at predicted brain current densities that are over an order of magnitude above those produced by conventional tDCS.
Journal ArticleDOI
How does hormesis impact biology, toxicology, and medicine?
TL;DR: A working compartmentalization of hormesis is established into ten categories that provide an integrated understanding of the biological meaning and applications of horm Genesis to aid in designing and interpreting future studies.
Journal Article
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: Treatment with rhEPO significantly improved functional recovery, along with increases in density of cerebral microvessels at the stroke boundary and numbers of BrdU, doublecortin, and nestin immunoreactive cells in the SVZ.
Journal ArticleDOI
Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks
TL;DR: The present analysis reveals that hormetic biphasic dose responses were associated with both the conditioning process and the protective effects elicited following the challenging dose, indicating that the biological/biomedical effects induced by conditioning represent a specific type of hormetic dose response and thereby contribute significantly to a generalization of the hormetic concept.
Journal ArticleDOI
Mechanisms and Effects of Transcranial Direct Current Stimulation.
James Giordano,Marom Bikson,Emily S. Kappenman,Vincent P. Clark,H. Branch Coslett,Michael R. Hamblin,Roy H. Hamilton,Ryan Jankord,Walter J. Kozumbo,R. Andrew McKinley,Michael A. Nitsche,J. Patrick Reilly,Jessica D. Richardson,Rachel Wurzman,Edward J. Calabrese +14 more
TL;DR: The most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research were discussed at a recent meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine as mentioned in this paper.
References
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Journal ArticleDOI
Erythropoietin protects PC12 cells from β-amyloid25–35-induced apoptosis via PI3K/Akt signaling pathway
TL;DR: Protective effects of erythropoietin (EPO) on Abeta(25-35)-induced cell death in cultured rat pheochromocytoma cells (PC12 cells) are investigated and it is demonstrated that EPO is an effective neuroprotective agent and is a viable candidate for treating AD.
Journal ArticleDOI
S100B protects LAN-5 neuroblastoma cells against Abeta amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses.
Rita Businaro,Stefano Leone,Cinzia Fabrizi,Giovanni Sorci,Rosario Donato,Giuliana M. Lauro,Lorenzo Fumagalli +6 more
TL;DR: The data suggest that at nanomolar doses S100B counteracts Aβ peptide neurotoxicity in a RAGE‐mediated manner, however, at micromolar dosesS100B is toxic to LAN‐5 cells and its toxicity adds to that of the A β peptide, suggesting that additional molecular mechanisms may be involved in the neurotoxic process.
Journal ArticleDOI
Ouabain protects rat hearts against ischemia-reperfusion injury via pathway involving src kinase, mitoKATP, and ROS.
Philippe Pasdois,Casey L. Quinlan,Abraham Rissa,Liliane Tariosse,Béatrice Vinassa,Alexandre D.T. Costa,Sandrine V. Pierre,Pierre Dos Santos,Keith D. Garlid +8 more
TL;DR: It is shown that bradykinin (BK)-induced cardioprotection was blocked by inhibitors of cGMP-dependent protein kinase (PKG) or guanylyl cyclase (GC), whereas ouabain-induced protection was not blocked by either agent.
Journal ArticleDOI
Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion
Christelle Kamga Pride,Li Mo,Kelly M. Quesnelle,Ruben K. Dagda,Daniel Murillo,Lisa Geary,Catherine Corey,Rafael de Lima Portella,Sergey Zharikov,Claudette M. St. Croix,Salony Maniar,Charleen T. Chu,Nicholas K.H. Khoo,Sruti Shiva +13 more
TL;DR: These data are the first to demonstrateNitrite-dependent normoxic modulation of both mitochondrial morphology and function and reveal a novel signalling pathway responsible for nitrite-mediated cardioprotection.
Journal ArticleDOI
Preventive effect of pretreatment with low dose of metals on the acute toxicity of metals in mice
TL;DR: It can be concluded that pretreated mice show a tolerance to the toxic action of most of contaminant metals and do not to that of essential metals.
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