Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
Citations
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Journal ArticleDOI
Hormesis: Path and Progression to Significance
TL;DR: How hormesis enhances resilience to normal aging and protects against a broad spectrum of neurodegenerative, cardiovascular, and other diseases, as well as trauma and other threats to health and well-being is assessed.
Journal ArticleDOI
Antimicrobial and hormetic effects of silver nanoparticles on in vitro regeneration of vanilla (Vanilla planifolia Jacks. ex Andrews) using a temporary immersion system
José Luis Spinoso-Castillo,Rocio Alejandra Chavez-Santoscoy,Nina Bogdanchikova,Juan Antonio Pérez-Sato,V. Morales-Ramos,Jericó J. Bello-Bello +5 more
TL;DR: Results suggested that the production of ROS and mineral nutrition are key mechanisms of AgNPs-induced hormesis for vanilla and use of Argovit could be an efficient strategy for commercial micropropagation of vanilla and other species.
Journal ArticleDOI
Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease
Manuela Pennisi,Rosalia Crupi,Rosanna Di Paola,Maria Laura Ontario,Rita Bella,Edward J. Calabrese,Roberto Crea,Salvatore Cuzzocrea,Vittorio Calabrese +8 more
TL;DR: The hormetic dose–response concept and possible mechanisms and applications to neuroprotection are introduced and the potential therapeutic utility of the nutritional antioxidants sulforaphane and hydroxytyrosol against particular signs and symptoms of AD is proposed.
Journal ArticleDOI
Hormesis in plants: Physiological and biochemical responses.
Arshad Jalal,José Carlos de Oliveira Junior,Janaína Santos Ribeiro,Guilherme Carlos Fernandes,Giovana Guerra Mariano,Vanessa Dias Rezende Trindade,André Rodrigues dos Reis +6 more
TL;DR: This review compiles information on how hormesis in plants can be used to achieve new production levels and identifies herbicides with active ingredients glyphosate, 2,4-D and paraquat as potential candidates.
Journal ArticleDOI
Nanoparticle Exposure and Hormetic Dose-Responses: An Update.
TL;DR: The evidence presented confirmed and extended previous findings, showing that hormesis is a generalized adaptive response which may be further generalized to nanoscale xenobiotic challenges.
References
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Journal ArticleDOI
Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium.
TL;DR: The multiple anginal episodes that often precede myocardial infarction in man may delay cell death after coronary occlusion, and thereby allow for greater salvage of myocardium through reperfusion therapy, which is proposed to protect the heart from a subsequent sustained ischemic insult.
Journal ArticleDOI
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Anna-Leena Sirén,Maddalena Fratelli,Michael Brines,Christoph G. Goemans,Simona Casagrande,Piotr Lewczuk,Sonja Keenan,Christoph H. Gleiter,Claudio Pasquali,Annalisa Capobianco,Tiziana Mennini,Rolf Heumann,Anthony Cerami,Hannelore Ehrenreich,Pietro Ghezzi +14 more
TL;DR: Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well.
Journal ArticleDOI
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
John W. Elrod,John W. Calvert,Joanna Morrison,Jeannette E. Doeller,David W. Kraus,Ling Tao,Xiangying Jiao,Rosario Scalia,Levente Kiss,Csaba Szabó,Hideo Kimura,Chi Wing Chow,David J. Lefer +12 more
TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.
Journal ArticleDOI
Adaptive Response of Human Lymphocytes to Low Concentrations of Radioactive Thymidine
TL;DR: When human lymphocytes were cultured with [3H]thymidine, which acts as a source of low-level chronic radiation, and then exposed to 150 rad of x-rays at 5, 7, 9, or 11 hours before fixation, the yield of chromatid aberrations was less than the sum of the yields of aberration induced by [3 H]thcyidine and x-ray separately.
Journal ArticleDOI
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: The data suggest that EPO-increased VEGF and BDNF may be involved in angiogenesis and neurogenesis, which could contribute to functional recovery.
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