Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
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Journal ArticleDOI
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.
Marom Bikson,Pnina Grossman,Chris Thomas,Adantchede L. Zannou,Jimmy Jiang,Tatheer Adnan,Antonios P. Mourdoukoutas,Greg Kronberg,Dennis Q. Truong,Paulo S. Boggio,Andre R. Brunoni,Leigh Charvet,Felipe Fregni,Brita Fritsch,Bernadette T. Gillick,Roy H. Hamilton,Benjamin M. Hampstead,Ryan Jankord,Adam Kirton,Helena Knotkova,David Liebetanz,Anli Liu,Colleen Loo,Michael A. Nitsche,Janine Reis,Janine Reis,Jessica D. Richardson,Alexander Rotenberg,Peter E. Turkeltaub,Adam J. Woods +29 more
TL;DR: Evidence from relevant animal models indicates that brain injury by Direct Current Stimulation (DCS) occurs at predicted brain current densities that are over an order of magnitude above those produced by conventional tDCS.
Journal ArticleDOI
How does hormesis impact biology, toxicology, and medicine?
TL;DR: A working compartmentalization of hormesis is established into ten categories that provide an integrated understanding of the biological meaning and applications of horm Genesis to aid in designing and interpreting future studies.
Journal Article
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: Treatment with rhEPO significantly improved functional recovery, along with increases in density of cerebral microvessels at the stroke boundary and numbers of BrdU, doublecortin, and nestin immunoreactive cells in the SVZ.
Journal ArticleDOI
Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks
TL;DR: The present analysis reveals that hormetic biphasic dose responses were associated with both the conditioning process and the protective effects elicited following the challenging dose, indicating that the biological/biomedical effects induced by conditioning represent a specific type of hormetic dose response and thereby contribute significantly to a generalization of the hormetic concept.
Journal ArticleDOI
Mechanisms and Effects of Transcranial Direct Current Stimulation.
James Giordano,Marom Bikson,Emily S. Kappenman,Vincent P. Clark,H. Branch Coslett,Michael R. Hamblin,Roy H. Hamilton,Ryan Jankord,Walter J. Kozumbo,R. Andrew McKinley,Michael A. Nitsche,J. Patrick Reilly,Jessica D. Richardson,Rachel Wurzman,Edward J. Calabrese +14 more
TL;DR: The most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research were discussed at a recent meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine as mentioned in this paper.
References
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Journal ArticleDOI
The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction
Alessandra Bosutti,Hans Degens +1 more
TL;DR: Low resveratrol doses promoted in vitro muscle regeneration and attenuated the impact of ROS, while high doses augmented the reduced plasticity and metabolism induced by oxidative stress.
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Effect of pretreatment with hydrogen sulfide donor sodium hydrosulfide on heat tolerance in relation to antioxidant system in maize (Zea mays) seedlings
TL;DR: In this article, the effect of sodium hydrosulfide (NaHS), a H2S donor, treatment on heat tolerance of maize seedlings in relation to antioxidant system was investigated.
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Ethanolamine is a novel STAT-3 dependent cardioprotective agent
R. Kelly,Kim Lamont,Sarin Somers,Damian Hacking,Lydia Lacerda,Paul Thomas,Lionel H. Opie,Sandrine Lecour +7 more
TL;DR: A novel cardioprotective role for ethanolamine against I/R injury via activation of STAT-3 is suggested, which is a critical prosurvival factor in ischaemia/reperfusion (I/R) injury.
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Biphasic protective effect of oxytocin on cardiac ischemia/reperfusion injury in anaesthetized rats
TL;DR: The result of this study shows that OT possess a dose-dependent cardioprotective effect against ischemia/reperfusion injury and so study of OT preconditioning may provide a new target site for therapeutic exploitation.
Book ChapterDOI
Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture.
TL;DR: Protective mechanisms of ginsenoside Rd may involve interference with iNOS and COX-2 expression, and could equally be demonstrated by a reduction of NO-formation and PGE2 synthesis.
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