Journal ArticleDOI
Preconditioning is hormesis part I: Documentation, dose-response features and mechanistic foundations.
TLDR
It is shown that pre- and postconditioning are specific types of hormesis, and the first documentation that hormetic effects account for preconditioning induced early and delayed windows of protection are provided.About:
This article is published in Pharmacological Research.The article was published on 2016-08-01. It has received 161 citations till now. The article focuses on the topics: Hormesis.read more
Citations
More filters
Journal ArticleDOI
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016.
Marom Bikson,Pnina Grossman,Chris Thomas,Adantchede L. Zannou,Jimmy Jiang,Tatheer Adnan,Antonios P. Mourdoukoutas,Greg Kronberg,Dennis Q. Truong,Paulo S. Boggio,Andre R. Brunoni,Leigh Charvet,Felipe Fregni,Brita Fritsch,Bernadette T. Gillick,Roy H. Hamilton,Benjamin M. Hampstead,Ryan Jankord,Adam Kirton,Helena Knotkova,David Liebetanz,Anli Liu,Colleen Loo,Michael A. Nitsche,Janine Reis,Janine Reis,Jessica D. Richardson,Alexander Rotenberg,Peter E. Turkeltaub,Adam J. Woods +29 more
TL;DR: Evidence from relevant animal models indicates that brain injury by Direct Current Stimulation (DCS) occurs at predicted brain current densities that are over an order of magnitude above those produced by conventional tDCS.
Journal ArticleDOI
How does hormesis impact biology, toxicology, and medicine?
TL;DR: A working compartmentalization of hormesis is established into ten categories that provide an integrated understanding of the biological meaning and applications of horm Genesis to aid in designing and interpreting future studies.
Journal Article
Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats
TL;DR: Treatment with rhEPO significantly improved functional recovery, along with increases in density of cerebral microvessels at the stroke boundary and numbers of BrdU, doublecortin, and nestin immunoreactive cells in the SVZ.
Journal ArticleDOI
Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks
TL;DR: The present analysis reveals that hormetic biphasic dose responses were associated with both the conditioning process and the protective effects elicited following the challenging dose, indicating that the biological/biomedical effects induced by conditioning represent a specific type of hormetic dose response and thereby contribute significantly to a generalization of the hormetic concept.
Journal ArticleDOI
Mechanisms and Effects of Transcranial Direct Current Stimulation.
James Giordano,Marom Bikson,Emily S. Kappenman,Vincent P. Clark,H. Branch Coslett,Michael R. Hamblin,Roy H. Hamilton,Ryan Jankord,Walter J. Kozumbo,R. Andrew McKinley,Michael A. Nitsche,J. Patrick Reilly,Jessica D. Richardson,Rachel Wurzman,Edward J. Calabrese +14 more
TL;DR: The most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research were discussed at a recent meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine as mentioned in this paper.
References
More filters
Journal ArticleDOI
Dual effects of isoflurane on proliferation, differentiation, and survival in human neuroprogenitor cells.
TL;DR: The commonly used general anesthetic isoflurane exerts dual effects on neuronal stem cell survival, proliferation, and differentiation, which may be attributed to differential regulation of calcium release through activation of endoplasmic reticulum localized inositol-1,4,5-trisphosphate and/or ryanodine receptors.
Journal ArticleDOI
Optimal Windows of Statin Use for Immediate Infarct Limitation 5-Nucleotidase as Another Downstream Molecule of Phosphatidylinositol 3-Kinase
Shoji Sanada,Hiroshi Asanuma,Tetsuo Minamino,Koichi Node,Seiji Takashima,Hiroko Okuda,Yoshiro Shinozaki,Akiko Ogai,Masashi Fujita,Akio Hirata,Jiyoong Kim,Yoshihiro Asano,Hidezo Mori,Hitonobu Tomoike,Soichiro Kitamura,Masatsugu Hori,Masafumi Kitakaze +16 more
TL;DR: In this paper, the authors investigated the effect of statins on ischemic-reperfusion injury and the underlying mechanisms of such effects in an in vivo canine model, and they found that myocardial phosphatidylinositol 3-kinase (PI3-K) and 5′-nucleotidase activities were measured.
Journal ArticleDOI
Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease.
TL;DR: Results of this study indicate that raloxifene exerted partial estrogen agonist action in the absence of 17 beta-estradiol whereas in the presence of 17 Beta-ESTradiol, ral oxifenes exerted a mixed estrogen agonists-antagonist effect.
Journal ArticleDOI
Progesterone with Vitamin D Affords Better Neuroprotection against Excitotoxicity in Cultured Cortical Neurons than Progesterone Alone
TL;DR: It is suggested that VDH warrants study as a potential partner for combination therapy with progesterone and 1,25-dihydroxyvitamin D3 hormone following excitotoxic neuronal injury in vitro.
Related Papers (5)
The hormesis database: the occurrence of hormetic dose responses in the toxicological literature.
The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview.
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J. Calabrese,Kenneth Bachmann,A. John Bailer,P. Michael Bolger,Jonathan Borak,Lu Cai,Nina Cedergreen,M. George Cherian,Chuang Chin Chiueh,Thomas W. Clarkson,Ralph R. Cook,David M. Diamond,David J. Doolittle,Michael A. Dorato,Stephen O. Duke,Ludwig E. Feinendegen,Donald E. Gardner,Ronald W. Hart,Kenneth L. Hastings,A. Wallace Hayes,George R. Hoffmann,John A. Ives,Zbigniew Jaworowski,Thomas E. Johnson,Wayne B. Jonas,Norbert E. Kaminski,John G. Keller,James E. Klaunig,Thomas B. Knudsen,Walter J. Kozumbo,Teresa Lettieri,Shu Zheng Liu,Andre Maisseu,Kenneth I. Maynard,Edward J. Masoro,Roger O. McClellan,Harihara M. Mehendale,Carmel Mothersill,David B. Newlin,Herbert N. Nigg,Frederick W. Oehme,Robert F. Phalen,Martin A. Philbert,Suresh I. S. Rattan,Jim E. Riviere,Joseph Rodricks,Robert M. Sapolsky,Bobby R. Scott,Colin Seymour,David A. Sinclair,Joan Smith-Sonneborn,Elizabeth T. Snow,Linda P. Spear,Donald E. Stevenson,Yolene Thomas,Maurice Tubiana,Gary M. Williams,Mark P. Mattson +57 more