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Open AccessJournal ArticleDOI

Psychedelics Promote Structural and Functional Neural Plasticity

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TLDR
It is reported that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo.
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This article is published in Cell Reports.The article was published on 2018-06-12 and is currently open access. It has received 436 citations till now.

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A qualitative and quantitative account of patient’s experiences of ketamine and its antidepressant properties:

TL;DR: Ketamine is central to one of the most rapidly growing areas of neuroscientific research into novel treatments for depression as discussed by the authors, and limited research has indicated that the psychedelic propert...
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Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits.

TL;DR: Results show for the first time a selective increase of GDNF specifically in the VTA for I40 but not for I20 after 24 h of administration, which agrees with the effective dose found in previous self-administration studies in rodents.
Book ChapterDOI

An introduction to psychedelic neuroscience

TL;DR: This chapter is an introduction to the volume "Psychedelic Neuroscience" of Elsevier's Progress in Brain Research addressing the neurobiological mechanisms of psychedelic drugs, the resulting changes in brain activity and integration of traditional viewpoints.
References
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Journal ArticleDOI

A simple practice guide for dose conversion between animals and human.

TL;DR: This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling and the method of calculation of injection volume for parenteral formulation based on human equivalent dose.
Journal ArticleDOI

Antidepressant effects of ketamine in depressed patients

TL;DR: A first placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate (NMDA) receptor antagonist in patients with depression suggests a potential role for NMDA receptor-modulating drugs in the treatment of depression.
Journal ArticleDOI

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

TL;DR: Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.
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