Psychedelics Promote Structural and Functional Neural Plasticity
Calvin Ly,Alexandra C. Greb,Lindsay P. Cameron,Jonathan M. Wong,Eden V. Barragan,Paige C. Wilson,Kyle F. Burbach,Sina Soltanzadeh Zarandi,Alexander Sood,Michael R. Paddy,Whitney C. Duim,Megan Y. Dennis,A. Kimberley McAllister,Kassandra M. Ori-McKenney,John A. Gray,David E. Olson +15 more
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TLDR
It is reported that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo.About:
This article is published in Cell Reports.The article was published on 2018-06-12 and is currently open access. It has received 436 citations till now.read more
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REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics.
TL;DR: A leading model of global brain function, hierarchical predictive coding, is integrated with an often-cited model of the acute action of psychedelics, the entropic brain hypothesis, which states that psychedelics work to relax high-level priors, sensitising them to liberated bottom-up information flow, which can help guide and cultivate the revision of entrenched pathological priors.
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Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders.
TL;DR: State-of-the art studies have recently begun to close important knowledge gaps by elucidating the mechanisms of action of psychedelics with regard to their effects on receptor subsystems, systems-level brain activity and connectivity, and cognitive and emotional processing.
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The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.
TL;DR: It is proposed that the subjective effects of psychedelics are necessary for their enduring beneficial effects and that these subjective effects account for the majority of their benefit.
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A non-hallucinogenic psychedelic analogue with therapeutic potential
Lindsay P. Cameron,Robert J. Tombari,Ju Lu,Alexander J. Pell,Zefan Q. Hurley,Yann Ehinger,Maxemiliano V. Vargas,Matthew N. McCarroll,Jack C. Taylor,Douglas Myers-Turnbull,Taohui Liu,Bianca Yaghoobi,Lauren J. Laskowski,Emilie I. Anderson,Guoliang Zhang,Jayashri Viswanathan,Brandon M. Brown,Michelle Tjia,Lee E. Dunlap,Zachary Rabow,Oliver Fiehn,Heike Wulff,John D. McCorvy,Pamela J. Lein,David Kokel,Dorit Ron,Jamie Peters,Yi Zuo,David E. Olson +28 more
TL;DR: This work demonstrates that, through careful chemical design, it is possible to modify a psychedelic compound to produce a safer, non-hallucinogenic variant that has therapeutic potential.
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Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer:
Gabrielle Agin-Liebes,Tara C. Malone,Matthew M. Yalch,Sarah E. Mennenga,K Linnae Ponté,Jeffrey Guss,Anthony P. Bossis,Jim Grigsby,Stacy Fischer,Stephen Ross +9 more
TL;DR: In this paper, a randomized controlled trial compared single-dose psilocybin with singledose niacin in conjunction with psychotherapy in participants with cancer-related psychiatric disorders.
References
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Harnessing neuroplasticity for clinical applications
Steven C. Cramer,Mriganka Sur,Bruce H. Dobkin,Charles J O'Brien,Terence D. Sanger,John Q. Trojanowski,Judith M. Rumsey,Ramona Hicks,Judy L. Cameron,Daofen Chen,Wen G. Chen,Leonardo G. Cohen,Christopher deCharms,Charles J. Duffy,Guinevere F. Eden,Eberhard E. Fetz,Rosemarie Filart,Michelle Freund,Steven J. Grant,Suzanne N. Haber,Peter W. Kalivas,Bryan Kolb,Arthur F. Kramer,Minda Lynch,Helen S. Mayberg,Patrick S. McQuillen,Ralph Nitkin,Alvaro Pascual-Leone,Patricia A. Reuter-Lorenz,Nicholas D. Schiff,Anu Sharma,Lana Shekim,Michael P. Stryker,Edith V. Sullivan,Sophia Vinogradov +34 more
TL;DR: Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies.
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Simple Neurite Tracer
TL;DR: An application for semi-automated tracing of neurons to quickly annotate noisy datasets and construct complex neuronal topologies, called the Simple Neurite Tracer, which can be used on Windows, Mac OS and Linux.
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Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study
Robin L. Carhart-Harris,Mark Bolstridge,James Rucker,Camilla M. Day,David Erritzoe,Mendel Kaelen,Michael A P Bloomfield,James Rickard,Ben Forbes,Amanda Feilding,David Taylor,Steve Pilling,Valerie Curran,David J. Nutt +13 more
TL;DR: Preliminary support for the safety and efficacy of psilocybin for treatment-resistant depression is provided and motivates further trials, with more rigorous designs, to better examine the therapeutic potential of this approach.
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Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer
Charles S. Grob,Alicia L. Danforth,Gurpreet S. Chopra,Marycie Hagerty,Charles R. McKay,Adam L. Halberstadt,George R. Greer +6 more
TL;DR: This study established the feasibility and safety of administering moderate doses of psilocybin to patients with advanced-stage cancer and anxiety and revealed a positive trend toward improved mood and anxiety.
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Replication of ketamine's antidepressant efficacy in bipolar depression: a randomized controlled add-on trial.
Carlos A. Zarate,Nancy E. Brutsche,Lobna Ibrahim,Jose A. Franco-Chaves,Nancy Diazgranados,Anibal Cravchik,Jessica Selter,Craig A. Marquardt,Victoria Liberty,David A. Luckenbaugh +9 more
TL;DR: This study replicated the previous finding that patients with bipolar depression who received a single ketamine infusion experienced a rapid and robust antidepressant response, and found that ketamine rapidly improved suicidal ideation in these patients.