Randomized Noninferiority Trial of Telephone Versus In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer
Marc Schwartz,Heiddis B. Valdimarsdottir,Beth N. Peshkin,Jeanne S. Mandelblatt,Rachel Nusbaum,An Tsun Huang,Yaojen Chang,Kristi D. Graves,Claudine Isaacs,Marie E. Wood,Wendy McKinnon,Judy Garber,Shelley R. McCormick,Anita Y. Kinney,George Luta,Sarah A. Kelleher,Kara Grace Leventhal,Patti Vegella,Angie Tong,Lesley King +19 more
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TLDR
Genetic counseling can be effectively and efficiently delivered via telephone to increase access and decrease costs.Abstract:
Purpose Although guidelines recommend in-person counseling before BRCA1/BRCA2 gene testing, genetic counseling is increasingly offered by telephone. As genomic testing becomes more common, evaluating alternative delivery approaches becomes increasingly salient. We tested whether telephone delivery of BRCA1/2 genetic counseling was noninferior to in-person delivery. Patients and Methods Participants (women age 21 to 85 years who did not have newly diagnosed or metastatic cancer and lived within a study site catchment area) were randomly assigned to usual care (UC; n = 334) or telephone counseling (TC; n = 335). UC participants received in-person pre- and post-test counseling; TC participants completed all counseling by telephone. Primary outcomes were knowledge, satisfaction, decision conflict, distress, and quality of life; secondary outcomes were equivalence of BRCA1/2 test uptake and costs of delivering TC versus UC. Results TC was noninferior to UC on all primary outcomes. At 2 weeks after pretest coun...read more
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Society of Gynecologic Oncology statement on risk assessment for inherited gynecologic cancer predispositions
TL;DR: This commentary provides guidance on identification of patients who may benefit from assessment for the presence of a hereditary breast and/or gynecologic cancer syndrome.
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Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019
Veda N. Giri,Karen E. Knudsen,William Kevin Kelly,Heather H. Cheng,Kathleen A. Cooney,Michael S. Cookson,William L. Dahut,Scott Weissman,Howard R. Soule,Daniel P. Petrylak,Adam P. Dicker,Saud H. AlDubayan,Amanda E. Toland,Colin C. Pritchard,Curtis A. Pettaway,Mary B. Daly,James L. Mohler,J. Kellogg Parsons,Peter R. Carroll,Robert Pilarski,Amie Blanco,Ashley H. Woodson,Alanna Kulchak Rahm,Mary-Ellen Taplin,Thomas J. Polascik,Brian T. Helfand,Colette Hyatt,Alicia K. Morgans,Felix Y. Feng,Michael Russell Mullane,Jacqueline Powers,Raoul S. Concepcion,Daniel W. Lin,Richard C. Wender,James Ryan Mark,Anthony J. Costello,Arthur L. Burnett,Oliver Sartor,William B. Isaacs,Jianfeng Xu,Jeffrey N. Weitzel,Gerald L. Andriole,Himisha Beltran,Alberto Briganti,Lindsey Byrne,Anne Calvaresi,Thenappan Chandrasekar,David Y.T. Chen,Robert B. Den,Albert Dobi,E. David Crawford,James A. Eastham,Scott E. Eggener,Matthew L. Freedman,Marc B. Garnick,Patrick T. Gomella,Nathan Handley,Mark D. Hurwitz,Joseph K Izes,R. Jeffrey Karnes,Costas D. Lallas,Lucia R. Languino,Stacy Loeb,Ana Maria Lopez,Kevin R. Loughlin,Grace L. Lu-Yao,S. Bruce Malkowicz,Mark Mann,Patrick Mille,Martin Miner,Todd M. Morgan,Jose Moreno,Lorelei A. Mucci,Ronald E. Myers,Sarah M. Nielsen,Brock O'Neil,Wayne H. Pinover,Peter A. Pinto,Wendy Poage,Ganesh V. Raj,Timothy R. Rebbeck,Charles J. Ryan,Howard M. Sandler,Matthew J. Schiewer,E. Michael D. Scott,Brittany M. Szymaniak,William Tester,Edouard J. Trabulsi,Neha Vapiwala,Evan Y. Yu,Charnita Zeigler-Johnson,Leonard G. Gomella +91 more
TL;DR: This multidisciplinary, consensus-driven PCA genetic implementation framework provides novel guidance to clinicians and patients tailored to the precision era and includes optimal pretest informed consent, post-test discussion, cascade testing, and technology-based approaches.
Journal ArticleDOI
Randomized Trial of Telegenetics vs. In-Person Cancer Genetic Counseling: Cost, Patient Satisfaction and Attendance
Adam H. Buchanan,Santanu K. Datta,Santanu K. Datta,Celette Sugg Skinner,Gail P. Hollowell,Henry F. Beresford,Thomas Freeland,Benjamin Rogers,John C. Boling,P. Kelly Marcom,P. Kelly Marcom,Martha B. Adams +11 more
TL;DR: It was found that telegenetics cost less than in-person counseling, with high satisfaction among those who attended, and this study provides support for future randomized trials comparing multiple service delivery models on longer-term psychosocial and behavioral outcomes.
Journal ArticleDOI
How I diagnose and manage individuals at risk for inherited myeloid malignancies.
Jane E. Churpek,Lucy A. Godley +1 more
TL;DR: The methods to identify, test, and manage individuals and families suspected of having a hereditary myeloid malignancy syndrome are presented and the areas of ongoing research in the field are addressed.
Journal ArticleDOI
Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women.
Ranjit Manchanda,Ranjit Manchanda,Ranjit Manchanda,Shreeya Patel,Shreeya Patel,Vladimir S. Gordeev,Antonis C. Antoniou,Shantel Smith,Andy C. H. Lee,John L. Hopper,Robert J. MacInnis,Clare Turnbull,Susan J. Ramus,Susan J. Ramus,Simon A. Gayther,Paul D.P. Pharoah,Usha Menon,Ian Jacobs,Ian Jacobs,Rosa Legood +19 more
TL;DR: In this article, the authors evaluated the cost-effectiveness of population-based panel testing for high and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations.
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