Recent advances in the IL-17 cytokine family
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TLDR
A review of recent advances in the field of IL-17/IL-17 receptor family biology, with an emphasis on IL- 17A biology.About:
This article is published in Current Opinion in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Janus kinase 1 & Common gamma chain.read more
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Role of cytokines in intervertebral disc degeneration: pain and disc content.
TL;DR: An enhanced understanding of the contribution of cytokines and immune cells to these catabolic, angiogenic and nociceptive processes could provide new targets for the treatment of symptomatic disc disease.
Journal ArticleDOI
STAT3 signaling in immunity.
TL;DR: Information on the numerous and distinct biological actions of STAT3 is summarized, and recent discoveries are highlighted, with a specific focus on STAT3 function in the immune and hematopoietic systems.
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The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.
David Martin,Jennifer E. Towne,Gregory Kricorian,Paul Klekotka,Johann E. Gudjonsson,James G. Krueger,Chris B. Russell +6 more
TL;DR: This review focuses on the emerging biology of the IL- 17 cytokine family in psoriasis, and on the molecular and genetic information gained from animal models and human clinical studies that confirm IL-17 as a crucial proinflammatory cytokine in psoriatic lesions.
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TRAF molecules in cell signaling and in human diseases
TL;DR: An overview of the current knowledge of TRAFs is presented, with an emphasis on recent findings concerning TRAF molecules in signaling and in human diseases.
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The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis.
TL;DR: The immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, is reviewed, along with the rationale for targeting the IL-17 cytokine family (IL-17A, Il-17F, and IL- 17 receptor A) in the treatment of psoriasis and psoratic arthritis.
References
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T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ
Xuexian O. Yang,Bhanu P. Pappu,Roza Nurieva,Askar M. Akimzhanov,Hong Soon Kang,Yeonseok Chung,Li Ma,Bhavin Shah,Athanasia D. Panopoulos,Kimberly S. Schluns,Stephanie S. Watowich,Qiang Tian,Anton M. Jetten,Chen Dong +13 more
TL;DR: Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma, and is induced by transforming growth factor-beta and interleukin-6 (IL-6), which is dependent on signal transducer and activator of transcription 3.
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Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
Arian Laurence,Cristina M. Tato,Todd S. Davidson,Yuka Kanno,Zhi Chen,Zhengju Yao,Rebecca Blank,Françoise Meylan,Richard M. Siegel,Lothar Hennighausen,Ethan M. Shevach,John J. O'Shea +11 more
TL;DR: It is demonstrated that in addition to the promotion of activation-induced cell death of lymphocytes and the generation of Treg cells, inhibition of Th17 polarization appears to be an important function of IL-2.
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IL-23 and IL-17 in the establishment of protective pulmonary CD4 + T cell responses after vaccination and during Mycobacterium tuberculosis challenge
Shabaana A. Khader,Guy K. Bell,John E. Pearl,Jeffrey J. Fountain,Javier Rangel-Moreno,Garth E Cilley,Fang Shen,Sheri M. Eaton,Sarah L. Gaffen,Susan L. Swain,Richard M. Locksley,Laura Haynes,Troy D. Randall,Andrea M. Cooper +13 more
TL;DR: It is proposed that vaccination induces IL-17-producing CD4+ T cells that populate the lung and, after challenge, trigger the production of chemokines that recruit CD4- T cells producing interferon-γ, which ultimately restrict bacterial growth.
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A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.
TL;DR: The evolution of the understanding of the TH17 pathway illuminates a shift in immunologists' perspectives regarding the basis of tissue damage, where for over 20 years the role of TH1 cells was considered paramount.
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Innate IL-17-producing cells: the sentinels of the immune system
Daniel J. Cua,Cristina M. Tato +1 more
TL;DR: The many innate immune cell populations that are an early source of IL-17 in response to stress, injury or pathogens are explored.