Recent advances in the IL-17 cytokine family
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TLDR
A review of recent advances in the field of IL-17/IL-17 receptor family biology, with an emphasis on IL- 17A biology.About:
This article is published in Current Opinion in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Janus kinase 1 & Common gamma chain.read more
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Role of cytokines in intervertebral disc degeneration: pain and disc content.
TL;DR: An enhanced understanding of the contribution of cytokines and immune cells to these catabolic, angiogenic and nociceptive processes could provide new targets for the treatment of symptomatic disc disease.
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STAT3 signaling in immunity.
TL;DR: Information on the numerous and distinct biological actions of STAT3 is summarized, and recent discoveries are highlighted, with a specific focus on STAT3 function in the immune and hematopoietic systems.
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The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.
David Martin,Jennifer E. Towne,Gregory Kricorian,Paul Klekotka,Johann E. Gudjonsson,James G. Krueger,Chris B. Russell +6 more
TL;DR: This review focuses on the emerging biology of the IL- 17 cytokine family in psoriasis, and on the molecular and genetic information gained from animal models and human clinical studies that confirm IL-17 as a crucial proinflammatory cytokine in psoriatic lesions.
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TRAF molecules in cell signaling and in human diseases
TL;DR: An overview of the current knowledge of TRAFs is presented, with an emphasis on recent findings concerning TRAF molecules in signaling and in human diseases.
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The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis.
TL;DR: The immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, is reviewed, along with the rationale for targeting the IL-17 cytokine family (IL-17A, Il-17F, and IL- 17 receptor A) in the treatment of psoriasis and psoratic arthritis.
References
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Impaired T H 17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Joshua D. Milner,Jason M. Brenchley,Jason M. Brenchley,Arian Laurence,Alexandra F. Freeman,Brenna J. Hill,Kevin M. Elias,Kevin M. Elias,Yuka Kanno,Christine Spalding,Houda Elloumi,Michelle L. Paulson,Joie Davis,Amy P. Hsu,Ava I. Asher,John J. O'Shea,Steven M. Holland,William E. Paul,Daniel C. Douek +18 more
TL;DR: Ex vivo T cells from subjects with HIES failed to produce IL-17, but not IL-2, tumour-necrosis factor or interferon-γ, on mitogenic stimulation with staphylococcal enterotoxin B or on antigenic stimulation with Candida albicans or streptokinase, which is consistent with a crucial role for STAT3 signalling in the generation of TH17 cells.
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Late Developmental Plasticity in the T Helper 17 Lineage
Yun Kyung Lee,Henrietta Turner,Craig L. Maynard,James R. Oliver,Dongquan Chen,Charles O. Elson,Casey T. Weaver +6 more
TL;DR: Mice deficient for STAT4 and T-bet-two prototypical Th1 transcription factors are protected from autoimmunity associated with Th17 pathogenesis and support a model of late Th17 developmental plasticity with implications for autoIMmunity and host defense.
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Fate mapping of IL-17-producing T cells in inflammatory responses
Keiji Hirota,João H. Duarte,Marc Veldhoen,Marc Veldhoen,Eve Hornsby,Ying Li,Daniel J. Cua,Helena Ahlfors,Christoph Wilhelm,Mauro Tolaini,Ursula Menzel,Anna Garefalaki,Alexandre J. Potocnik,Brigitta Stockinger +13 more
TL;DR: A reporter mouse strain designed to map the fate of cells that have activated interleukin 17A (IL-17A) allows the actual functional fate of effector T cells to be related to TH17 developmental origin regardless of IL-17 expression.
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The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Mohamed El-Behi,Bogoljub Ciric,Hong Dai,Yaping Yan,Melissa Cullimore,Farinaz Safavi,Guang-Xian Zhang,Bonnie N. Dittel,Abdolmohamad Rostami +8 more
TL;DR: Cross-regulation of IL-23 and GM- CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies TH17 cells as a crucial source of GM-CSF in autoimmune inflammation.
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Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
Heather R. Conti,Fang Shen,Namrata Nayyar,Eileen Stocum,Jianing N. Sun,Matthew J. Lindemann,Allen W. Ho,Justine Hoda Hai,Jeffrey J. Yu,Ji Won Jung,Scott G. Filler,Patricia A. Masso-Welch,Mira Edgerton,Sarah L. Gaffen,Sarah L. Gaffen +14 more
TL;DR: The Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors.