Recent advances in the IL-17 cytokine family
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TLDR
A review of recent advances in the field of IL-17/IL-17 receptor family biology, with an emphasis on IL- 17A biology.About:
This article is published in Current Opinion in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Janus kinase 1 & Common gamma chain.read more
Citations
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Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection.
Ruth Seelige,Robert Saddawi-Konefka,Nicholas M. Adams,Gaelle Picarda,Joseph C. Sun,Joseph C. Sun,Chris A. Benedict,Jack D. Bui +7 more
TL;DR: It is shown that early immune cell accumulation at the peritoneal site of infection by mouse cytomegalovirus (MCMV) is mediated by IL-17D, and therapeutic benefit is suggested in boosting this pathway to promote innate antiviral responses.
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Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects.
Marwa Chehimi,Maud Robert,Michel El Bechwaty,Guillaume Vial,Jennifer Rieusset,Hubert Vidal,Luciano Pirola,Assia Eljaafari +7 more
TL;DR: The results suggest that, as ASC, adipocytes in obese AT might contribute to the establishment of a low-grade chronic inflammation state.
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Regulation of IL-17A and implications for TGF-β1 comodulation of airway smooth muscle remodeling in severe asthma
Jon M. Evasovic,Cherie A. Singer +1 more
TL;DR: The evidence demonstrating the extent to which IL-17A interacts with various immune factors, specifically TGF-β1, to contribute to ASM remodeling and altered function in TH17-driven endotypes of severe asthma is reviewed.
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Association of IL-17A and IL-17F polymorphisms with gastric cancer risk in Asians: A meta-analysis
TL;DR: IL-17A rs2275913 A/G polymorphism and IL-17F rs763780 C/T polymorphism might be associated with increased GC risk in Asians and further large-scale studies are still required to confirm the results.
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IL-17E (IL-25) and IL-17A differentially affect the functions of human keratinocytes
Julia Borowczyk,C. Buerger,Neschaat Tadjrischi,Justyna Drukala,Michal Wolnicki,Dawid Wnuk,Ali Modarressi,Wolf-Henning Boehncke,Nicolò Costantino Brembilla +8 more
TL;DR: It is shown here that IL-22 enhances IL-17E production in human keratinocytes and that these cells display a complete IL- 17E receptor at their surface, which expression is further induced by IL-16A, indicating a potential autocrine effect of IL-18E.
References
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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I. Ivanov,Brent S. McKenzie,Liang Zhou,Carlos E. Tadokoro,Alice Lepelley,Juan J. Lafaille,Daniel J. Cua,Dan R. Littman +7 more
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Richard H. Duerr,Kent D. Taylor,Steven R. Brant,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Mark J. Daly,Mark J. Daly,A. Hillary Steinhart,Clara Abraham,Miguel Regueiro,Anne M. Griffiths,Themistocles Dassopoulos,Alain Bitton,Huiying Yang,Stephan R. Targan,Lisa W. Datta,Emily O. Kistner,L. Philip Schumm,Annette Lee,Peter K. Gregersen,M. Michael Barmada,Jerome I. Rotter,Dan L. Nicolae,Judy H. Cho +25 more
TL;DR: A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.
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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Craig A. Murphy,Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Terrill K. McClanahan,Robert A. Kastelein,Jonathon D. Sedgwick,Daniel J. Cua +7 more
TL;DR: The data presented here indicate that IL-23 is an essential promoter of end-stage joint autoimmune inflammation, whereas IL-12 paradoxically mediates protection from autoimmune inflammation.