Recent advances in the IL-17 cytokine family
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TLDR
A review of recent advances in the field of IL-17/IL-17 receptor family biology, with an emphasis on IL- 17A biology.About:
This article is published in Current Opinion in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Janus kinase 1 & Common gamma chain.read more
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Anti-psoriasis effect of water-processed rosin in mice
Xiao Qiang Li,Yong Chen,Yong Chen,Hong Mei Zhou,Hui Li Shi,Xiao Ning Yan,Li Ping Lin,Ren-Xiang Tan,Ren-Xiang Tan +8 more
TL;DR: WBR is effective in the imiquimod-induced psoriasis-like inflammation mouse model with the efficacy arising from its proliferation inhibition of Th1/Th17 cells and epidermal keratinocytes via the down-regulation of the relevant inflammatory cytokines such as IL-23, IL-17A, and IL- 17F.
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Verification of IL-17A and IL-17F in oral tissues and modulation of their expression pattern by steroid hormones.
TL;DR: IL-17F was discriminatively regulated by testosterone and 17β-estradiol in resident periodontal cells, showing distinct patterns for the subtypes IL-17A and IL- 17F.
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IL-17/IL-17 Receptor Pathway–Mediated Inflammatory Response in <i>Apostichopus japonicus</i> Supports the Conserved Functions of Cytokines in Invertebrates
TL;DR: In this article , an inflammatory model in the Vibrio splendidus-challenged sea cucumber Apostichopus japonicus (Echinodermata) was established and the functional role of invertebrate IL-17 in inflammatory regulation was not well understood.
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Role of interleukin-17A in early graft rejection after orthotopic lung transplantation in mice
TL;DR: Antibody neutralization of IL-17A diminished the signs of acute rejection at 7 days after transplantation in allografts, and this early protection was accompanied by a decrease in cellular stress according to histological evaluation, suggesting the involvement of IL -17A in the development of early post-transplantation lesions.
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Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes.
Bastian Welz,Rolf Bikker,Johannes Junemann,Martin Christmann,Konstantin Neumann,Mareike Weber,Leonie Hoffmeister,Katharina Preuß,Andreas Pich,René Huber,Korbinian Brand +10 more
TL;DR: The experiments demonstrate that both proteome and phosphoproteome analysis can be effectively applied to study protein/phosphorylation patterns of primary monocytes and provide new regulatory candidates and evidence for a complex network of specific but synergistically acting/cooperating mechanisms enabling the affected cells to resist sustained TNF exposure and resulting in the resolution of inflammation.
References
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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I. Ivanov,Brent S. McKenzie,Liang Zhou,Carlos E. Tadokoro,Alice Lepelley,Juan J. Lafaille,Daniel J. Cua,Dan R. Littman +7 more
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
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Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
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A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Richard H. Duerr,Kent D. Taylor,Steven R. Brant,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Mark J. Daly,Mark J. Daly,A. Hillary Steinhart,Clara Abraham,Miguel Regueiro,Anne M. Griffiths,Themistocles Dassopoulos,Alain Bitton,Huiying Yang,Stephan R. Targan,Lisa W. Datta,Emily O. Kistner,L. Philip Schumm,Annette Lee,Peter K. Gregersen,M. Michael Barmada,Jerome I. Rotter,Dan L. Nicolae,Judy H. Cho +25 more
TL;DR: A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.
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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Craig A. Murphy,Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Terrill K. McClanahan,Robert A. Kastelein,Jonathon D. Sedgwick,Daniel J. Cua +7 more
TL;DR: The data presented here indicate that IL-23 is an essential promoter of end-stage joint autoimmune inflammation, whereas IL-12 paradoxically mediates protection from autoimmune inflammation.