Recent advances in the IL-17 cytokine family
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TLDR
A review of recent advances in the field of IL-17/IL-17 receptor family biology, with an emphasis on IL- 17A biology.About:
This article is published in Current Opinion in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Janus kinase 1 & Common gamma chain.read more
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Role of cytokines in intervertebral disc degeneration: pain and disc content.
TL;DR: An enhanced understanding of the contribution of cytokines and immune cells to these catabolic, angiogenic and nociceptive processes could provide new targets for the treatment of symptomatic disc disease.
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STAT3 signaling in immunity.
TL;DR: Information on the numerous and distinct biological actions of STAT3 is summarized, and recent discoveries are highlighted, with a specific focus on STAT3 function in the immune and hematopoietic systems.
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The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings.
David Martin,Jennifer E. Towne,Gregory Kricorian,Paul Klekotka,Johann E. Gudjonsson,James G. Krueger,Chris B. Russell +6 more
TL;DR: This review focuses on the emerging biology of the IL- 17 cytokine family in psoriasis, and on the molecular and genetic information gained from animal models and human clinical studies that confirm IL-17 as a crucial proinflammatory cytokine in psoriatic lesions.
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TRAF molecules in cell signaling and in human diseases
TL;DR: An overview of the current knowledge of TRAFs is presented, with an emphasis on recent findings concerning TRAF molecules in signaling and in human diseases.
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The Immunologic Role of IL-17 in Psoriasis and Psoriatic Arthritis Pathogenesis.
TL;DR: The immunologic role of interleukin (IL)-17, the major effector cytokine in the pathogenesis of psoriatic disease, is reviewed, along with the rationale for targeting the IL-17 cytokine family (IL-17A, Il-17F, and IL- 17 receptor A) in the treatment of psoriasis and psoratic arthritis.
References
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LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis a phase I randomized, double-blind, placebo-controlled, proof-of-concept study
Mark C. Genovese,F. Van den Bosch,S. A. Roberson,S. Bojin,I. M. Biagini,Peter F J Ryan,J. Sloan-Lancaster +6 more
TL;DR: LY2439821 added to oral DMARDs improved signs and symptoms of RA, with no strong adverse safety signal noted, and supports neutralization of IL-17 as a potential novel goal for the treatment of RA.
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Transcriptional regulation of Th17 cell differentiation
TL;DR: How the nuclear orphan receptor RORgammat functions to coordinate the diverse cytokine-induced signals and thus controls Th17 cell differentiation is reviewed.
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Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice
Lin Lin,Ashraf S. Ibrahim,Xin Xu,Joshua M. Farber,Valentina Avanesian,Beverlie Baquir,Yue Fu,Samuel W. French,Samuel W. French,John E. Edwards,Brad Spellberg,Brad Spellberg +11 more
TL;DR: RAls3p-N vaccination induced a Th1/Th17 response, resulting in recruitment and activation of phagocytes at sites of infection, and more effective clearance of S. aureus and C. albicans from tissues, suggesting vaccine-mediated adaptive immunity can protect against both infections by targeting microbes for destruction by innate effectors.
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1,25-Dihydroxyvitamin D 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A
Sneha Joshi,Luiz C. Pantalena,Xikui Liu,Sarah L. Gaffen,Sarah L. Gaffen,Hong Liu,Christine Rohowsky-Kochan,Kenji Ichiyama,Akihiko Yoshimura,Lawrence Steinman,Sylvia Christakos,Sawsan Youssef +11 more
TL;DR: In vivo treatment of mice with ongoing experimental autoimmune encephalomyelitis diminishes paralysis and progression of the disease and reduces IL-17A-secreting T cells in the periphery and central nervous system (CNS).
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Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa
TL;DR: Recent progress is summarized in understanding of the function of IL-17-producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.