Recent advances in the IL-17 cytokine family
Reads0
Chats0
TLDR
A review of recent advances in the field of IL-17/IL-17 receptor family biology, with an emphasis on IL- 17A biology.About:
This article is published in Current Opinion in Immunology.The article was published on 2011-10-01 and is currently open access. It has received 258 citations till now. The article focuses on the topics: Janus kinase 1 & Common gamma chain.read more
Citations
More filters
Journal ArticleDOI
Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas.
TL;DR: The discovery of five novel IL-17 homologs in the Pacific oyster genome suggests that CgIL-17s are involved in innate immune responses and further supports their conserved function in mollusks immunity.
Journal ArticleDOI
TRAF Molecules in Inflammation and Inflammatory Diseases
TL;DR: Increasing evidence indicates that TRAF molecules are versatile and indispensable regulators of inflammation and inflammatory responses and that aberrant expression or function of TRAFs contributes to the pathogenesis of inflammatory diseases.
Journal ArticleDOI
Transcriptome of American oysters, Crassostrea virginica, in response to bacterial challenge: insights into potential mechanisms of disease resistance.
Ian C. McDowell,Chamilani Nikapitiya,Derek Aguiar,Christopher E. Lane,Sorin Istrail,Marta Gomez-Chiarri +5 more
TL;DR: The identification of potential genes and processes responsible for defense against R. crassostreae in the American oyster provides insights into potential mechanisms of disease resistance.
Journal ArticleDOI
T helper 17 cells may drive neuroprogression in major depressive disorder: Proposal of an integrative model.
Anastasiya Slyepchenko,Michael Maes,Cristiano A. Köhler,George M. Anderson,João Quevedo,Gilberto Alves,Michael Berk,Brisa Simoes Fernandes,André F. Carvalho +8 more
TL;DR: An integrative model is proposed suggesting that T helper 17 (Th17) cells play a pivotal role in the pathophysiology of MDD through microglial activation, interactions with oxidative and nitrosative stress, increases of autoantibody production and the propensity for autoimmunity, and dysregulation of the gut mucosa and microbiota.
Journal ArticleDOI
Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases.
TL;DR: The function of IL-17A is focused on, in particular the proposed roles of IL -17A, in the pathogenesis of neurodegenerative diseases and the mechanisms of action are shown to be more subtle than simply causing inflammation.
References
More filters
Journal ArticleDOI
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.
Ivaylo I. Ivanov,Brent S. McKenzie,Liang Zhou,Carlos E. Tadokoro,Alice Lepelley,Juan J. Lafaille,Daniel J. Cua,Dan R. Littman +7 more
TL;DR: It is shown that the orphan nuclear receptor RORgammat is the key transcription factor that orchestrates the differentiation of this effector cell lineage of proinflammatory T helper cells and its potential as a therapeutic target in inflammatory diseases is highlighted.
Journal ArticleDOI
Interleukin 17–producing CD4 + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
Laurie E. Harrington,Robin D. Hatton,Paul R. Mangan,Henrietta Turner,Theresa L. Murphy,Kenneth M. Murphy,Casey T. Weaver +6 more
TL;DR: Findings provide a basis for understanding how inhibition of IFN-γ signaling enhances development of pathogenic TH-17 effector cells that can exacerbate autoimmunity.
Journal ArticleDOI
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
Heon Park,Zhaoxia Li,Xuexian O. Yang,Seon Hee Chang,Roza Nurieva,Yi Hong Wang,Ying Wang,Leroy Hood,Zhou Zhu,Qiang Tian,Chen Dong +10 more
TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.
Journal ArticleDOI
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Richard H. Duerr,Kent D. Taylor,Steven R. Brant,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Mark J. Daly,Mark J. Daly,A. Hillary Steinhart,Clara Abraham,Miguel Regueiro,Anne M. Griffiths,Themistocles Dassopoulos,Alain Bitton,Huiying Yang,Stephan R. Targan,Lisa W. Datta,Emily O. Kistner,L. Philip Schumm,Annette Lee,Peter K. Gregersen,M. Michael Barmada,Jerome I. Rotter,Dan L. Nicolae,Judy H. Cho +25 more
TL;DR: A highly significant association is found between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23, which prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease.
Journal ArticleDOI
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
Craig A. Murphy,Claire L. Langrish,Yi Yi Chen,Wendy M. Blumenschein,Terrill K. McClanahan,Robert A. Kastelein,Jonathon D. Sedgwick,Daniel J. Cua +7 more
TL;DR: The data presented here indicate that IL-23 is an essential promoter of end-stage joint autoimmune inflammation, whereas IL-12 paradoxically mediates protection from autoimmune inflammation.