Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial: Clinical article
Edward G. Shaw,B. Berkey,Stephen W. Coons,Dennis E. Bullard,David Brachman,Jan C. Buckner,Keith J. Stelzer,Geoffrey R. Barger,Paul D. Brown,Mark R. Gilbert,Minesh P. Mehta +10 more
TLDR
It is suggested that young adult patients with low-grade glioma who undergo a neurosurgeon-determined GTR have a > 50% risk of tumor progression 5-years postoperatively, warranting close follow-up and consideration for adjuvant treatment.Abstract:
Object In 1998, the Radiation Therapy Oncology Group initiated a Phase II study of observation for adults < 40 years old with cerebral low-grade glioma who underwent a neurosurgeon-determined gross-total resection (GTR). Methods Patient eligibility criteria included the presence of a World Health Organization Grade II astrocytoma, oligodendroglioma, or mixed oligoastrocytoma confirmed histologically; age 18–39 years; Karnofsky Performance Scale score ≥ 60; Neurologic Function Scale score ≤ 3; supratentorial tumor location; neurosurgeon-determined GTR; and pre- and postoperative MR imaging with contrast enhancement available for central review by the principal investigator. Patients were observed following GTR and underwent MR imaging every 6 months. Prognostic factors analyzed for their contribution to patient overall survival, progression-free survival (PFS), and tumor recurrence included age, sex, Karnofsky Performance Scale score, Neurologic Function Scale score, histological type, contrast enhancement...read more
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Clinical practice guidelines in oncology
William J. Gradishar,Benjamin O. Anderson,Ron Balassanian,Sarah L. Blair,Harold J. Burstein,Amy E. Cyr,Anthony D. Elias,William B. Farrar,Andres Forero,Sharon H. Giordano,Matthew P. Goetz,Lori J. Goldstein,Steven J. Isakoff,Janice A. Lyons,P. Kelly Marcom,Ingrid A. Mayer,Beryl McCormick,Meena S. Moran,Ruth O'Regan,Sameer A. Patel,Lori J. Pierce,Elizabeth C. Reed,Kilian E. Salerno,Lee S. Schwartzberg,Amy Sitapati,Karen L. Smith,Mary Lou Smith,Hatem Soliman,George Somlo,Melinda L. Telli,John H. Ward,Rashmi Kumar,Dorothy A. Shead +32 more
TL;DR: This manuscript focuses on the NCCN Guidelines Panel recommendations for the workup, primary treatment, risk reduction strategies, and surveillance specific to DCIS.
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Histological Typing of tumours of the Central Nervous System
TL;DR: A histological classification of CNS Tumours is presented, highlighting the importance of knowing the carrier and removal status of canine coronavirus as a source of infection for humans.
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Comparison of a strategy favoring early surgical resection vs a strategy favoring watchful waiting in low-grade gliomas.
Asgeir Store Jakola,Kristin Smistad Myrmel,Roar Kloster,Sverre H. Torp,Sigurd Lindal,Geirmund Unsgård,Ole Solheim +6 more
TL;DR: For patients in Norway with LGG, treatment at a center that favored early surgical resection was associated with better overall survival than treatment at one that favored biopsy and watchful waiting, and this survival benefit remained after adjusting for validated prognostic factors.
Journal ArticleDOI
Guidelines on management of low-grade gliomas: report of an EFNS–EANO* Task Force
Riccardo Soffietti,Brigitta G. Baumert,Lorenzo Bello,A. von Deimling,Hugues Duffau,Marc Frenay,Wolfgang Grisold,Robin Grant,Francesc Graus,Khê Hoang-Xuan,Martin Klein,Beatrice Melin,Jeremy Rees,Tali Siegal,Anja Smits,Roger Stupp,Wolfgang Wick +16 more
TL;DR: Diffuse infiltrative low‐grade gliomas of the cerebral hemispheres in the adult are a group of tumors with distinct clinical, histological and molecular characteristics, and there are still controversies in management.
Journal ArticleDOI
Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas
M. J. van den Bent,Jeffrey S. Wefel,David Schiff,Martin J.B. Taphoorn,Kurt A. Jaeckle,Larry Junck,Terri Armstrong,Terri Armstrong,A. Choucair,Adam D. Waldman,Thierry Gorlia,Marc C. Chamberlain,Brigitta G. Baumert,Michael A. Vogelbaum,David R. Macdonald,David A. Reardon,Patrick Y. Wen,Susan M. Chang,Andreas H. Jacobs +18 more
TL;DR: Clinical and imaging endpoints in trials of low-grade gliomas are investigated, response assessment in neuro-oncology (RANO) criteria for non-enhancing tumours is provided, and other measures for patients with brain tumours that assess outcome are described.
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Histological Typing of tumours of the Central Nervous System
TL;DR: A histological classification of CNS Tumours is presented, highlighting the importance of knowing the carrier and removal status of canine coronavirus as a source of infection for humans.
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