Journal ArticleDOI
Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies
Alexandra D. Frolkis,Jonathan Dykeman,Maria Negron,Jennifer deBruyn,Nathalie Jette,Kirsten M. Fiest,Talia Frolkis,Herman W. Barkema,Kevin P. Rioux,Remo Panaccione,Subrata Ghosh,Samuel Wiebe,Gilaad G. Kaplan +12 more
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TLDR
The risk of intestinal surgery among patients with IBD has decreased over the past 6 decades, and the trend in risk of surgery over time was analyzed by meta-regression using mixed-effect models.About:
This article is published in Gastroenterology.The article was published on 2013-11-01. It has received 623 citations till now. The article focuses on the topics: Inflammatory bowel disease & Population.read more
Citations
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Stromal Cells in the Pathogenesis of Inflammatory Bowel Disease.
Marieke C. Barnhoorn,S K Hakuno,Ramona S Bruckner,Ramona S Bruckner,Gerhard Rogler,Lukas J. A. C. Hawinkels,Michael Scharl +6 more
TL;DR: In this review, the current knowledge of the role of stromal cells in IBD pathogenesis is discussed and recent attempts to modify theStromal compartment in I BD with agents that target or replace the pathogenic stroma are outlined.
Journal ArticleDOI
Extracellular Vesicles in Inflammatory Bowel Disease: Small Particles, Big Players.
TL;DR: Functional roles of extracellular vesicles in health and disease are summarized, with a focus on immune regulation and intestinal barrier integrity, and recent studies on extraceocytes and inflammatory bowel disease are reviewed.
Journal ArticleDOI
Cost-utility of biological treatment sequences for luminal Crohn's disease in Europe.
Fanni Rencz,László Gulácsi,Márta Péntek,Krisztina Gecse,Axel Dignass,Jonas Halfvarson,Fernando Gomollón,Petra Baji,Laurent Peyrin-Biroulet,Peter L. Lakatos,Valentin Brodszky +10 more
TL;DR: In this paper, the authors compared the cost-effectiveness of treatment sequences with available biologics, including adalimumab (ADA), biosimilar infliximab (bsIFX), originator inflixIMab (IFX) and vedolizumab (VEDO), for luminal Crohn's disease in nine European countries.
Journal ArticleDOI
The future of nanomedicine in optimising the treatment of inflammatory bowel disease.
TL;DR: A review of conventional and novel therapies which have benefited from nanoparticle-mediated delivery and highlights the proven therapeutic efficacy of this approach in preclinical models suggests these strategies under development represent a novel and innovative treatment for IBD.
Journal ArticleDOI
Enteral Nutrition in Adult Crohn's Disease: Toward a Paradigm Shift.
Simona Di Caro,Konstantinos C. Fragkos,Katie Keetarut,Hui Fen Koo,Gregory Sebepos-Rogers,Hajeena Saravanapavan,J. Barragry,Jennifer K. Rogers,Shameer Mehta,Farooq Rahman +9 more
TL;DR: A comprehensive review of availableEnteral nutrition formulations and the literature supporting the use and mechanisms of action of enteral nutrition in adult Crohn’s disease patients are offered in order to support clinicians in real world decision-making when offering/accepting treatment.
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R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
Meta-analysis of observational studies in epidemiology - A proposal for reporting
Donna F. Stroup,Jesse A. Berlin,Sally C. Morton,Ingram Olkin,G. D. Williamson,Drummond Rennie,Drummond Rennie,David Moher,Betsy Jane Becker,Theresa Ann Sipe,Stephen B. Thacker +10 more
TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
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Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology
Mark S. Silverberg,Jack Satsangi,Tariq Ahmad,Ian D. Arnott,Charles N. Bernstein,Steven R. Brant,Renzo Caprilli,Jean-Frederic Colombel,Christoph Gasche,Karel Geboes,Derek P. Jewell,Amir Karban,Edward V. Loftus,A. Salvador Peña,Robert H. Riddell,David B. Sachar,Stefan Schreiber,A. Hillary Steinhart,Stephan R. Targan,Severine Vermeire,Bryan F. Warren +20 more