Journal ArticleDOI
Risk of Surgery for Inflammatory Bowel Diseases Has Decreased Over Time: A Systematic Review and Meta-analysis of Population-Based Studies
Alexandra D. Frolkis,Jonathan Dykeman,Maria Negron,Jennifer deBruyn,Nathalie Jette,Kirsten M. Fiest,Talia Frolkis,Herman W. Barkema,Kevin P. Rioux,Remo Panaccione,Subrata Ghosh,Samuel Wiebe,Gilaad G. Kaplan +12 more
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TLDR
The risk of intestinal surgery among patients with IBD has decreased over the past 6 decades, and the trend in risk of surgery over time was analyzed by meta-regression using mixed-effect models.About:
This article is published in Gastroenterology.The article was published on 2013-11-01. It has received 623 citations till now. The article focuses on the topics: Inflammatory bowel disease & Population.read more
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Ulcerative Colitis Patients With Clostridium difficile are at Increased Risk of Death, Colectomy, and Postoperative Complications: A Population-Based Inception Cohort Study.
Maria Negron,Ali Rezaie,Herman W. Barkema,Kevin P. Rioux,Jeroen De Buck,Sylvia Checkley,Paul L. Beck,Matthew W Carroll,Richard N. Fedorak,Levinus A. Dieleman,Remo Panaccione,Subrata Ghosh,Gilaad G. Kaplan +12 more
TL;DR: Clostridium difficile diagnosis worsens the prognosis of newly diagnosed patients with UC by increasing the risk of colectomy, postoperative complications, and death.
Journal ArticleDOI
Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer.
Magdalena Grill,Christoph Högenauer,Andreas Blesl,Johannes Haybaeck,Johannes Haybaeck,Johannes Haybaeck,Nicole Golob-Schwarzl,Nerea Ferreirós,Dominique Thomas,Robert Gurke,Martin Trötzmüller,Harald Köfeler,Birgit Gallé,Rudolf Schicho +13 more
TL;DR: Members of the ECS and related components of the ‘endocannabinoidome’ in patients with inflammatory bowel disease and CRC are determined and alterations for less known components in intestinal inflammation are reported, such as GPR119, OEA and LPI.
Journal ArticleDOI
The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases
Magali de Bruyn,Jennifer Vandooren,Estefania Ugarte-Berzal,I. Arijs,Severine Vermeire,Ghislain Opdenakker +5 more
TL;DR: Current literature on genetic association, mRNA, and protein expression studies with regard to MMPs and TIMPs in IBD patients and various animal models are summarized to compare biochemical and molecular biological data in humans with those obtained in animal model studies.
Journal ArticleDOI
A Simple Ultrasound Score for the Accurate Detection of Inflammatory Activity in Crohn's Disease.
Kerri L Novak,Gilaad G. Kaplan,Remo Panaccione,Elnaz Ehteshami Afshar,Divine Tanyingoh,Mark G. Swain,Amelia Kellar,Stephanie Wilson +7 more
TL;DR: A simple ultrasonographic score that accurately identifies Crohn's disease activity has been developed and validated and may be a surrogate for endoscopy to guide disease management, but future studies should be conducted to establish interrater variability.
Journal ArticleDOI
Surgical rates in the era of biological therapy: up, down or unchanged?
Pablo Olivera,Antonino Spinelli,Corinne Gower-Rousseau,Silvio Danese,Laurent Peyrin-Biroulet +4 more
TL;DR: Although data from population-based studies and available RCTs suggest a protective effect from surgery of anti-TNF agents, definitive conclusions should be drawn only when more disease-modifying trials with different biologics and treatment strategies become available.
References
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Mark S. Silverberg,Jack Satsangi,Tariq Ahmad,Ian D. Arnott,Charles N. Bernstein,Steven R. Brant,Renzo Caprilli,Jean-Frederic Colombel,Christoph Gasche,Karel Geboes,Derek P. Jewell,Amir Karban,Edward V. Loftus,A. Salvador Peña,Robert H. Riddell,David B. Sachar,Stefan Schreiber,A. Hillary Steinhart,Stephan R. Targan,Severine Vermeire,Bryan F. Warren +20 more