Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer
Milad Ashrafizadeh,Kiavash Hushmandi,Mehrdad Hashemi,Mohammad Esmaeil Akbari,Peter Kubatka,Mehdi Raei,Lenka Koklesova,Shahinozzaman,Reza Mohammadinejad,Masoud Najafi,Gautam Sethi,Alan Prem Kumar,Ali Zarrabi +12 more
- Vol. 10, Iss: 8, pp 1159
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TLDR
This review focuses on microRNAs (miRNAs) and their regulatory effect on epithelial-to-mesenchymal transition (EMT) mechanisms that can regulate metastasis ofadder cancer cells.Abstract:
Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall survival of patients with this life-threatening disorder. Recently, studies have focused on revealing molecular pathways involved in metastasis of BC cells, and in this review, we focus on microRNAs (miRNAs) and their regulatory effect on epithelial-to-mesenchymal transition (EMT) mechanisms that can regulate metastasis. EMT is a vital process for migration of BC cells, and inhibition of this mechanism restricts invasion of BC cells. MiRNAs are endogenous non-coding RNAs with 19-24 nucleotides capable of regulating different cellular events, and EMT is one of them. In BC cells, miRNAs are able to both induce and/or inhibit EMT. For regulation of EMT, miRNAs affect different molecular pathways such as transforming growth factor-beta (TGF-β), Snail, Slug, ZEB1/2, CD44, NSBP1, which are, discussed in detail this review. Besides, miRNA/EMT axis can also be regulated by upstream mediators such as lncRNAs, circRNAs and targeted by diverse anti-tumor agents. These topics are also discussed here to reveal diverse molecular pathways involved in migration of BC cells and strategies to target them to develop effective therapeutics.read more
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Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression
Milad Ashrafizadeh,Sepideh Mirzaei,Mohammad Hossein Gholami,Farid Hashemi,Amirhossein Zabolian,Mehdi Raei,Kiavash Hushmandi,Ali Zarrabi,Nicolas H. Voelcker,Amir Reza Aref,Michael R. Hamblin,Rajender S. Varma,Saeed Samarghandian,I.J. Arostegi,M. Alzola,Alan Prem Kumar,Vijay Kumar Thakur,Noushin Nabavi,Pooyan Makvandi,Franklin R. Tay,Gorka Orive +20 more
TL;DR: Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance.
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The long and short non-coding RNAs modulating EZH2 signaling in cancer
Sepideh Mirzaei,Mohammad Hossein Gholami,Kiavash Hushmandi,Farid Hashemi,Amirhossein Zabolian,Israel Cañadas,Ali Zarrabi,Noushin Nabavi,Amir Reza Aref,Francesco Crea,Yuzhuo Wang,Milad Ashrafizadeh,Alan Prem Kumar +12 more
TL;DR: In this paper , a mechanistic discussion of ncRNAs role in regulating EZH2 expression in different cancers is provided, with a focus on molecular pathways leading to clinical translation.
Journal ArticleDOI
New insight towards development of paclitaxel and docetaxel resistance in cancer cells: EMT as a novel molecular mechanism and therapeutic possibilities.
Milad Ashrafizadeh,Sepideh Mirzaei,Farid Hashemi,Ali Zarrabi,Amirhossein Zabolian,Hossein Saleki,Seyed Omid Sharifzadeh,Leyla Soleymani,Salman Daneshi,Kiavash Hushmandi,Haroon Khan,Alan Prem Kumar,Amir Reza Aref,Saeed Samarghandian +13 more
TL;DR: In this paper, three different strategies including using anti-tumor compounds, gene therapy and delivery systems have been developed for suppressing EMT, and enhancing cytotoxicity of PTX and DTX against cancer cells.
Journal ArticleDOI
Cytoskeletal Dynamics in Epithelial-Mesenchymal Transition: Insights into Therapeutic Targets for Cancer Metastasis.
Arpita Datta,Shuo Deng,Vennila Gopal,Kenneth Chun-Hong Yap,Clarissa Esmeralda Halim,Mun Leng Lye,Mei Shan Ong,Tuan Zea Tan,Gautam Sethi,Shing Chuan Hooi,Alan Prem Kumar,Celestial T. Yap,Celestial T. Yap +12 more
TL;DR: In this article, a review summarizes the physiological functions of the cytoskeleton, its role in the epithelial to mesenchymal transition (EMT) process, and its effect on multidrug resistant (MDR) cancer cells.
Journal ArticleDOI
Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery
Sepideh Mirzaei,Ali Zarrabi,Farid Hashemi,Amirhossein Zabolian,Hossein Saleki,Negar Azami,Soodeh Hamzehlou,Mahdi Vasheghani Farahani,Kiavash Hushmandi,Milad Ashrafizadeh,Haroon Khan,Alan Prem Kumar +11 more
TL;DR: In this article, a review of the signaling networks in which Nrf2 is a key player for protection against DOX adverse effects has been revealed and are discussed in the current review.
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