Self-reported olfactory loss associates with outpatient clinical course in COVID-19.
TLDR
Self‐reported olfactory impairment has recently been recognized as a hallmark of COVID‐19 and may be an important predictor of clinical outcome.Abstract:
Author(s): Yan, Carol H; Faraji, Farhoud; Prajapati, Divya P; Ostrander, Benjamin T; DeConde, Adam S | Abstract: BackgroundRapid spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus has left many health systems around the world overwhelmed, forcing triaging of scarce medical resources. Identifying indicators of hospital admission for coronavirus disease 2019 (COVID-19) patients early in the disease course could aid the efficient allocation of medical interventions. Self-reported olfactory impairment has recently been recognized as a hallmark of COVID-19 and may be an important predictor of clinical outcome.MethodsA retrospective review of all patients presenting to a San Diego Hospital system with laboratory-confirmed positive COVID-19 infection was conducted with evaluation of olfactory and gustatory function and clinical disease course. Univariable and multivariable logistic regression were performed to identify risk factors for hospital admission and anosmia.ResultsA total of 169 patients tested positive for COVID-19 disease between March 3 and April 8, 2020. Olfactory and gustatory data were obtained for 128 (75.7%) of 169 subjects, of which 26 (20.1%) of 128 required hospitalization. Admission for COVID-19 was associated with intact sense of smell and taste, increased age, diabetes, and subjective and objective parameters associated with respiratory failure. On adjusted analysis, anosmia was strongly and independently associated with outpatient care (adjusted odds ratio [aOR] 0.09; 95% CI, 0.01-0.74), whereas positive findings of pulmonary infiltrates and/or pleural effusion on chest radiograph (aOR 8.01; 95% CI, 1.12-57.49) was strongly and independently associated with admission.ConclusionNormosmia is an independent predictor of admission in COVID-19 cases. Smell loss in COVID-19 may be associated with a milder clinical course.read more
Citations
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
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TL;DR: In this registry-based cohort study of patients with MS, age, EDSS, and obesity were independent risk factors for severe COVID-19; there was no association found between DMTs exposure and CO VID-19 severity.
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More Than Smell-COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis.
Valentina Parma,Kathrin Ohla,Maria G. Veldhuizen,Masha Y. Niv,Christine E. Kelly,Alyssa J. Bakke,Keiland W. Cooper,Cédric Bouysset,Nicola Pirastu,Michele Dibattista,Rishemjit Kaur,Marco Tullio Liuzza,Marta Yanina Pepino,Veronika Schöpf,S. Craig Roberts +14 more
TL;DR: Results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis, and suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.
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Smell and Taste Dysfunction in Patients With COVID-19: A Systematic Review and Meta-analysis.
TL;DR: There is a high prevalence of olfactory and gustatory dysfunctions among patients infected with COVID-19 and Routine screening for these conditions could contribute to improved case detection in the ongoing CO VID-19 pandemic.
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International consensus statement on allergy and rhinology: rhinosinusitis 2021
Richard R. Orlandi,Todd T. Kingdom,Timothy L. Smith,Benjamin S. Bleier,Adam S. DeConde,Amber U Luong,David M. Poetker,Zachary M. Soler,Kevin C. Welch,Sarah K. Wise,Nithin D. Adappa,Jeremiah A. Alt,Wilma Terezinha Anselmo-Lima,Claus Bachert,Claus Bachert,Claus Bachert,Fuad M. Baroody,Pete S. Batra,Manuel Bernal-Sprekelsen,Daniel M. Beswick,Neil Bhattacharyya,Rakesh K. Chandra,Eugene H. Chang,Alexander G. Chiu,Naweed I. Chowdhury,Martin J. Citardi,Noam A. Cohen,David B. Conley,John M. DelGaudio,Martin Desrosiers,Richard G. Douglas,Jean Anderson Eloy,Wytske Fokkens,Stacey T. Gray,David A. Gudis,Daniel L. Hamilos,Joseph K. Han,Richard J. Harvey,Peter Hellings,Eric H. Holbrook,Claire Hopkins,Peter H. Hwang,Amin R. Javer,Rong San Jiang,David N. Kennedy,Robert C. Kern,Tanya M. Laidlaw,Devyani Lal,Andrew P. Lane,Heung Man Lee,Jivianne T. Lee,Joshua M. Levy,Sandra Y. Lin,Valerie J. Lund,Kevin C. McMains,Ralph Metson,Joaquim Mullol,Robert M. Naclerio,Gretchen M. Oakley,Nobuyoshi Otori,James N. Palmer,Sanjay R. Parikh,Desiderio Passali,Zara M. Patel,Anju T. Peters,Carl Philpott,Alkis J. Psaltis,Vijay R. Ramakrishnan,Murugappan Ramanathan,Hwan Jung Roh,Luke Rudmik,Raymond Sacks,Rodney J. Schlosser,Ahmad R. Sedaghat,Brent A. Senior,Raj Sindwani,Kristine A. Smith,Kornkiat Snidvongs,Michael G. Stewart,Jeffrey D. Suh,Bruce K. Tan,Justin H. Turner,Cornelis M. van Drunen,Richard Louis Voegels,De Yun Wang,Bradford A. Woodworth,Peter-John Wormald,Erin D. Wright,Carol H. Yan,Luo Zhang,Bing Zhou +90 more
TL;DR: The 5 years since the publication of the first International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed foundational progress in the understanding and treatment of rhinologic disease.
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