Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
Philipp Schuetz,Robert H. Birkhahn,Robert Sherwin,Alan E. Jones,Adam J. Singer,Jeffrey A. Kline,Michael S. Runyon,Wesley H. Self,D. Mark Courtney,Richard M. Nowak,David F. Gaieski,Stefan Ebmeyer,Sascha Johannes,Jan C. Wiemer,Andrej Schwabe,Nathan I. Shapiro +15 more
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TLDR
Results of this large, prospective multicenter U.S. study indicate that inability to decrease procalcitonin by more than 80% is a significant independent predictor of mortality and may aid in sepsis care.Abstract:
Objectives:To prospectively validate that the inability to decrease procalcitonin levels by more than 80% between baseline and day 4 is associated with increased 28-day all-cause mortality in a large sepsis patient population recruited across the United States.Design:Blinded, prospective multicenterread more
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Precision medicine for the treatment of sepsis: recent advances and future prospects
Pedro Palma,Jordi Rello +1 more
TL;DR: The role of the dysentery in in-hospital mortality remains unchanged despite improvements in patient care, despite the improvements in care, in-Hospital mortality remained unchanged.
Journal ArticleDOI
The role of procalcitonin in identifying high-risk cancer patients with febrile neutropenia: A useful alternative to the multinational association for supportive care in cancer score.
Patrick Chaftari,Anne Marie Chaftari,Ray Y Hachem,Sai Ching J. Yeung,Hiba dagher,Ying Jiang,Alexandre E. Malek,Natalie Dailey Garnes,Victor E. Mulanovich,Issam I Raad +9 more
TL;DR: In this paper, the authors used the multinational Association for Supportive Care in Cancer (MASCC) risk index to determine the risk for poor clinical outcomes in patients with febrile neutropenia (FN) in an emergency center (EC).
Journal ArticleDOI
Is It All Clear if Procalcitonin Clears in Acute Pancreatitis
TL;DR: Is It All Clear if Procalcitonin Clears in Acute Pancreatitis?
Journal ArticleDOI
Prokalzitonin auf der Intensivstation
S Großmann,S Schroll,M Pfeifer +2 more
TL;DR: Prokalzitonin (PCT) wird bei systemischen Inflammationszustanden IL6-, IL8- and TNF-α-vermittelt in multiplen Organen und Strukturen des Korpers gebildet as discussed by the authors.
Journal ArticleDOI
Procalcitonin Correlates With but Is Not Superior to Other Diagnostic Markers of Bacterial Pneumonia
TL;DR: PCT was higher in patients diagnosed with bacterial pneumonia and less clear is its diagnostic ability to detect bacterial pneumonia over and above imaging and laboratory data routinely available to clinicians.
References
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The Strengthening the Reporting of Observational Studies in Epidemiology [STROBE] statement: guidelines for reporting observational studies
Erik von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
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The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
E von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
Journal ArticleDOI
Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.
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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
Jean Louis Vincent,R. Moreno,Jukka Takala,Sheila Willatts,A. de Mendonça,Hajo A. Bruining,C. K. Reinhart,P. M. Suter,L. G. Thijs +8 more
TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
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Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
R. Phillip Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Sean R. Townsend,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +22 more
TL;DR: A consensus committee of 68 international experts representing 30 international organizations was convened in 2008 to provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock".
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