Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
Philipp Schuetz,Robert H. Birkhahn,Robert Sherwin,Alan E. Jones,Adam J. Singer,Jeffrey A. Kline,Michael S. Runyon,Wesley H. Self,D. Mark Courtney,Richard M. Nowak,David F. Gaieski,Stefan Ebmeyer,Sascha Johannes,Jan C. Wiemer,Andrej Schwabe,Nathan I. Shapiro +15 more
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TLDR
Results of this large, prospective multicenter U.S. study indicate that inability to decrease procalcitonin by more than 80% is a significant independent predictor of mortality and may aid in sepsis care.Abstract:
Objectives:To prospectively validate that the inability to decrease procalcitonin levels by more than 80% between baseline and day 4 is associated with increased 28-day all-cause mortality in a large sepsis patient population recruited across the United States.Design:Blinded, prospective multicenterread more
Citations
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Journal ArticleDOI
Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections
Philipp Schuetz,Yannick Wirz,Ramon Sager,Mirjam Christ-Crain,Daiana Stolz,Michael Tamm,Lila Bouadma,Charles Edouard Luyt,Michel Wolff,Jean Chastre,Florence Tubach,Kristina B. Kristoffersen,Olaf Burkhardt,Tobias Welte,Stefan Schroeder,Vandack Nobre,Long Wei,Heiner C. Bucher,Neera Bhatnagar,Djillali Annane,Konrad Reinhart,Angela Branche,Pierre Damas,Maarten W. N. Nijsten,Dylan W. de Lange,Rodrigo Octavio Deliberato,Stella Ss Lima,Vera Maravic-Stojkovic,Alessia Verduri,Bin Cao,Yahya Shehabi,Albertus Beishuizen,Jens-Ulrik Stæhr Jensen,Caspar Corti,Jos A H van Oers,Ann R. Falsey,Evelien de Jong,Carolina F. Oliveira,Bianca Beghe,Matthias Briel,Beat Mueller +40 more
TL;DR: In this article, a systematic review included individual patient data from 14 randomised controlled trials with a total of 4211 participants and found no increased risk for all-cause mortality or treatment failure when procalcitonin was used to guide initiation and duration of antibiotic treatment in participants with acute respiratory infections compared to control participants.
Journal ArticleDOI
Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis
Philipp Schuetz,Yannick Wirz,Ramon Sager,Mirjam Christ-Crain,Mirjam Christ-Crain,Daiana Stolz,Daiana Stolz,Michael Tamm,Michael Tamm,Lila Bouadma,Charles Edouard Luyt,Michel Wolff,Jean Chastre,Florence Tubach,Kristina B. Kristoffersen,Olaf Burkhardt,Tobias Welte,Stefan Schroeder,Vandack Nobre,Long Wei,Heiner C. Bucher,Heiner C. Bucher,Djillali Annane,Konrad Reinhart,Ann R. Falsey,Angela Branche,Pierre Damas,Maarten W. N. Nijsten,Dylan W. de Lange,Rodrigo Octavio Deliberato,Carolina F. Oliveira,Vera Maravic-Stojkovic,Alessia Verduri,Bianca Beghe,Bin Cao,Yahya Shehabi,Jens-Ulrik Stæhr Jensen,Caspar Corti,Jos A H van Oers,Albertus Beishuizen,Armand R. J. Girbes,Evelien de Jong,Matthias Briel,Matthias Briel,Matthias Briel,Beat Mueller +45 more
TL;DR: Widespread implementation of procalcitonin protocols in patients with acute respiratory infections has the potential to improve antibiotic management with positive effects on clinical outcomes and on the current threat of increasing antibiotic multiresistance.
Journal ArticleDOI
Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis
TL;DR: The literature review reaffirms the continued common occurrence of septic shock and estimates a high mortality of around 38%.
Journal ArticleDOI
Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients : a patient-level meta-analysis of randomized trials
Yannick Wirz,Marc A. Meier,Lila Bouadma,Charles Edouard Luyt,Michel Wolff,Jean Chastre,Florence Tubach,Stefan Schroeder,Vandack Nobre,Djillali Annane,Konrad Reinhart,Pierre Damas,Maarten W. N. Nijsten,Arezoo Shajiei,Dylan W. deLange,Rodrigo Octavio Deliberato,Carolina F. Oliveira,Yahya Shehabi,Jos A H van Oers,Albertus Beishuizen,Armand R. J. Girbes,Evelien de Jong,Beat Mueller,Philipp Schuetz +23 more
TL;DR: Procalcitonin-guided antibiotic treatment in ICU patients with infection and sepsis patients results in improved survival and lower antibiotic treatment duration.
References
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Predictive value of procalcitonin decrease in patients with severe sepsis: a prospective observational study.
Sari Karlsson,Milja Heikkinen,Ville Pettilä,Seija Alila,Sari Väisänen,Kari Pulkki,Elina Kolho,Esko Ruokonen +7 more
TL;DR: PCT concentrations were higher in more severe forms of severe sepsis, but a substantial concentration decrease was more important for survival than absolute values.
Journal ArticleDOI
Risk Prediction With Procalcitonin and Clinical Rules in Community-Acquired Pneumonia
Journal ArticleDOI
Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients
TL;DR: In septic patients, procalcitonin kinetics over the first 72 critical care hours provide prognostic information beyond that available from clinical risk scores that may assist physician decision-making regarding care intensification or early transfer from the ICU to the floor.
Journal ArticleDOI
Procalcitonin-guided interventions against infections to increase early appropriate antibiotics and improve survival in the intensive care unit: A randomized trial
Journal ArticleDOI
A model to predict short-term death or readmission after intensive care unit discharge
Islem Ouanes,Carole Schwebel,Adrien Français,Cédric Bruel,François Philippart,François Philippart,Aurélien Vesin,Lilia Soufir,Christophe Adrie,Christophe Adrie,Maité Garrouste-Orgeas,Maité Garrouste-Orgeas,Jean-François Timsit,Benoit Misset,Benoit Misset +14 more
TL;DR: Independent risk factors were indicators of patients' severity and discharge at night, and the predictive model based on these variables showed good calibration, and should be evaluated in other ICU populations.
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