Serial Procalcitonin Predicts Mortality in Severe Sepsis Patients: Results From the Multicenter Procalcitonin MOnitoring SEpsis (MOSES) Study.
Philipp Schuetz,Robert H. Birkhahn,Robert Sherwin,Alan E. Jones,Adam J. Singer,Jeffrey A. Kline,Michael S. Runyon,Wesley H. Self,D. Mark Courtney,Richard M. Nowak,David F. Gaieski,Stefan Ebmeyer,Sascha Johannes,Jan C. Wiemer,Andrej Schwabe,Nathan I. Shapiro +15 more
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TLDR
Results of this large, prospective multicenter U.S. study indicate that inability to decrease procalcitonin by more than 80% is a significant independent predictor of mortality and may aid in sepsis care.Abstract:
Objectives:To prospectively validate that the inability to decrease procalcitonin levels by more than 80% between baseline and day 4 is associated with increased 28-day all-cause mortality in a large sepsis patient population recruited across the United States.Design:Blinded, prospective multicenterread more
Citations
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Combined Biomarkers Predict Acute Mortality Among Critically Ill Patients With Suspected Sepsis.
Brendan J Kelly,Ebbing Lautenbach,Irving Nachamkin,Susan E. Coffin,Jeffrey S. Gerber,Barry D. Fuchs,Charles Garrigan,Xiaoyan Han,Warren B. Bilker,Jacqueleen Wise,Pam Tolomeo,Jennifer H. Han,Prevention Epicenters Program +12 more
TL;DR: Combined biomarkers predict risk for 14-day and total mortality among subjects with suspected sepsis and combinations of biomarkers including serum amyloid P and tissue plasminogen activator achieved greater predictive performance.
Journal ArticleDOI
How to: implement procalcitonin testing in my practice
TL;DR: Procalcitonin provides information about risk for bacterial infection and resolution of infection, and improves antibiotic stewardship decisions, thereby offering more individualized treatment courses with overall reduced antibiotic exposure.
Journal ArticleDOI
Procalcitonin: A promising tool or just another overhyped test?
TL;DR: The history and pathophysiology of procalcitonin is discussed, its utility in the diagnosis and management of sepsis is synthesized, its limitations are highlighted and it is compared with other biomarkers in sepsi.
Journal ArticleDOI
Molecular and biomarker-based diagnostics in early sepsis: current challenges and future perspectives.
TL;DR: A review of host response-guided diagnostics and methods for direct pathogen detection of sepsis, defined as a life-threatening organ dysfunction resulting from dysregulated host response to infection, which has emerged over the last years.
Journal ArticleDOI
The ability of Procalcitonin, lactate, white blood cell count and neutrophil-lymphocyte count ratio to predict blood stream infection. Analysis of a large database.
Paul E. Marik,Elise Stephenson +1 more
TL;DR: The results suggest that PCT of less than 0.5 ng/mL may be an effective screening tool to exclude BSI as the cause of sepsis, while the diagnosis of BSI should be considered in patients with a PCT above this threshold.
References
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Erik von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items (the STROBE statement) that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
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The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
E von Elm,Douglas G. Altman,Matthias Egger,Matthias Egger,Stuart J. Pocock,Peter C Gøtzsche,Jan P. Vandenbroucke +6 more
TL;DR: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Initiative developed recommendations on what should be included in an accurate and complete report of an observational study, resulting in a checklist of 22 items that relate to the title, abstract, introduction, methods, results, and discussion sections of articles.
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Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis
Roger C. Bone,Robert A. Balk,F. B. Cerra,R. P. Dellinger,A. M. Fein,William A. Knaus,Roland M. H. Schein,W. J. Sibbald +7 more
TL;DR: An American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference was held in Northbrook in August 1991 with the goal of agreeing on a set of definitions that could be applied to patients with sepsis and its sequelae as mentioned in this paper.
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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.
Jean Louis Vincent,R. Moreno,Jukka Takala,Sheila Willatts,A. de Mendonça,Hajo A. Bruining,C. K. Reinhart,P. M. Suter,L. G. Thijs +8 more
TL;DR: The ESICM developed a so-called sepsis-related organ failure assessment (SOFA) score to describe quantitatively and as objectively as possible the degree of organ dysfunction/failure over time in groups of patients or even in individual patients.
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R. Phillip Dellinger,Mitchell M. Levy,Andrew Rhodes,Djillali Annane,Herwig Gerlach,Steven M. Opal,Jonathan E. Sevransky,Charles L. Sprung,Ivor S. Douglas,Roman Jaeschke,Tiffany M. Osborn,Mark E. Nunnally,Sean R. Townsend,Konrad Reinhart,Ruth M. Kleinpell,Derek C. Angus,Clifford S. Deutschman,Flávia Ribeiro Machado,Gordon D. Rubenfeld,Steven A R Webb,Richard Beale,Jean Louis Vincent,Rui Moreno +22 more
TL;DR: A consensus committee of 68 international experts representing 30 international organizations was convened in 2008 to provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock".
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