Sphingolipids and their metabolism in physiology and disease.
TLDR
These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingoipid metabolism to key human diseases.Abstract:
Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many functions, which rivals, if not exceeds, that of the genome or proteome. These results highlight critical roles for bioactive sphingolipids in most, if not all, major cell biological responses, including all major cell signalling pathways, and they link sphingolipid metabolism to key human diseases. Nevertheless, the fairly nascent field of bioactive sphingolipids still faces challenges in its biochemical and molecular underpinnings, including defining the molecular mechanisms of pathway and enzyme regulation, the study of lipid-protein interactions and the development of cellular probes, suitable biomarkers and therapeutic approaches.read more
Citations
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Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.
Bo Shen,Xiao Yi,Yaoting Sun,Xiaojie Bi,Juping Du,Chao Zhang,Sheng Quan,Fangfei Zhang,Rui Sun,Liujia Qian,Weigang Ge,Wei Liu,Shuang Liang,Hao Chen,Ying Zhang,Jun Li,Jiaqin Xu,Zebao He,Baofu Chen,Jing Wang,Haixi Yan,Yufen Zheng,Donglian Wang,Jiansheng Zhu,Ziqing Kong,Zhouyang Kang,Xiao Liang,Xuan Ding,Guan Ruan,Nan Xiang,Xue Cai,Huanhuan Gao,Lu Li,Sainan Li,Qi Xiao,Tian Lu,Yi Zhu,Huafen Liu,Haixiao Chen,Tiannan Guo +39 more
TL;DR: This study revealed characteristic protein and metabolite changes in the sera of severe COVID-19 patients, which might be used in selection of potential blood biomarkers for severity evaluation.
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Metabolites as regulators of insulin sensitivity and metabolism
TL;DR: A comprehensive understanding of the metabolic adaptations involved in insulin resistance may enable the identification of novel targets for improving insulin sensitivity and preventing, and treating, T2DM.
Journal ArticleDOI
Plant cell-surface GIPC sphingolipids sense salt to trigger Ca 2+ influx
Zhonghao Jiang,Xiaoping Zhou,Ming Tao,Fang Yuan,Fang Yuan,Lulu Liu,Lulu Liu,Fei-Hua Wu,Fei-Hua Wu,Fei-Hua Wu,Xiaomei Wu,Yun Xiang,Yue Niu,Feng Liu,Chijun Li,Rui Ye,Benjamin Byeon,Yan Xue,Hongyan Zhao,Hsin-Neng Wang,Bridget M. Crawford,Douglas M. Johnson,Chanxing Hu,Christopher Pei,Wenming Zhou,G. Swift,Han Zhang,Tuan Vo-Dinh,Zhangli Hu,James N. Siedow,Zhen-Ming Pei +30 more
TL;DR: This work isolated the Arabidopsis thaliana mutant monocation-induced [Ca2+]iincreases 1 (moca1), and identified MOCA1 as a glucuronosyltransferase for glycosyl inositol phosphorylceramide (GIPC) sphingolipids in the plasma membrane that triggers responses to excess salt such as efflux of sodium ions from cells.
Journal ArticleDOI
Bacteroides-Derived Sphingolipids Are Critical for Maintaining Intestinal Homeostasis and Symbiosis.
Eric M. Brown,Xiaobo Ke,Daniel S. Hitchcock,Sarah Jeanfavre,Julian Avila-Pacheco,Toru Nakata,Timothy D. Arthur,Nadine Fornelos,Cortney E. Heim,Eric A. Franzosa,Nicki Watson,Curtis Huttenhower,Curtis Huttenhower,Henry J. Haiser,Glen Dillow,Daniel B. Graham,B. Brett Finlay,Aleksandar Kostic,Jeffrey A. Porter,Hera Vlamakis,Hera Vlamakis,Clary B. Clish,Ramnik J. Xavier,Ramnik J. Xavier,Ramnik J. Xavier +24 more
TL;DR: The role of bacterial sphingolipids in maintaining homeostasis and symbiosis in the gut is highlighted and lower abundances in IBD and negative correlations with inflammation and host sphingoipid production are revealed.
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