Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.
Emma B. Hodcroft,Emma B. Hodcroft,Emma B. Hodcroft,Moira Zuber,Sarah Nadeau,Sarah Nadeau,Timothy G. Vaughan,Timothy G. Vaughan,Katharine H.D. Crawford,Katharine H.D. Crawford,Christian L. Althaus,Martina L. Reichmuth,John E. Bowen,Alexandra C. Walls,Davide Corti,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,David Veesler,David Mateo,Alberto Hernando,Iñaki Comas,Fernando González-Candelas,Tanja Stadler,Tanja Stadler,Richard A. Neher,Richard A. Neher +26 more
TLDR
A novel SARS-CoV-2 variant, 20E (EU1) that emerged in Spain in early summer, and subsequently spread across Europe is reported in this article.Abstract:
Following its emergence in late 2019, the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1,2 has been tracked via phylogenetic analysis of viral genome sequences in unprecedented detail3–5. While the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, within Europe travel resumed in the summer of 2020. Here we report on a novel SARS-CoV-2 variant, 20E (EU1), that emerged in Spain in early summer, and subsequently spread across Europe. We find no evidence of increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate 20E (EU1) was introduced hundreds of times to European countries by summertime travelers, likely undermining local efforts to keep SARS-CoV-2 cases low. Our results demonstrate how a variant can rapidly become dominant even in absence of a substantial transmission advantage in favorable epidemiological settings. Genomic surveillance is critical to understanding how travel can impact SARS-CoV-2 transmission, and thus for informing future containment strategies as travel resumes.read more
Citations
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The biological and clinical significance of emerging SARS-CoV-2 variants.
Kaiming Tao,Philip L Tzou,Janin Nouhin,Ravindra K. Gupta,Tulio de Oliveira,Sergei L Kosakovsky Pond,Daniela Fera,Robert W. Shafer +7 more
TL;DR: The emergence of SARS-CoV-2 variants with novel spike protein mutations that are influencing the epidemiological and clinical aspects of the COVID-19 pandemic has been witnessed as mentioned in this paper.
Journal ArticleDOI
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2.
Fang Tian,Bei Tong,Liang Sun,Shengchao Shi,Bin Zheng,Zibin Wang,Xianchi Dong,Xianchi Dong,Peng Zheng +8 more
TL;DR: In this paper, the authors used a cell surface-binding assay, a kinetics study, a single-molecule technique, and a computational method to investigate the interaction between these RBD (mutations) and ACE2.
Journal ArticleDOI
Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.
Kathryn M. Hastie,Haoyang Li,Daniel Bedinger,Sharon L. Schendel,S. Moses Dennison,Kan Li,Vamseedhar Rayaprolu,Xiaoying Yu,Colin Mann,Michelle Zandonatti,Ruben Diaz Avalos,Dawid Zyla,Tierra Buck,Sean Hui,Kelly Shaffer,Chitra Hariharan,Jieyun Yin,Eduardo Olmedillas,Adrian Enriquez,Diptiben V. Parekh,Milite Abraha,Elizabeth Feeney,Gillian Q. Horn,CoVIC-DB team,Yoann Aldon,Hanif Ali,Sanja Aracic,Ronald R. Cobb,Ross S. Federman,Joseph M. Fernandez,Jacob Glanville,Robin Green,Gevorg Grigoryan,Ana G. Lujan Hernandez,David D. Ho,Kuan-Ying A. Huang,John Ingraham,Weidong Jiang,Paul Kellam,Cheolmin Kim,Minsoo Kim,Hyeong Mi Kim,Chao Kong,Shelly J. Krebs,Fei Lan,Guojun Lang,Sooyoung Lee,Cheuk Lun Leung,Junli Liu,Yanan Lu,Anna J. MacCamy,Andrew T. McGuire,Anne L. Palser,Terence H. Rabbitts,Zahra Rikhtegaran Tehrani,Mohammad M. Sajadi,Rogier W. Sanders,Aaron K. Sato,Liang Schweizer,Jimin Seo,Bingqing Shen,Jonne L. Snitselaar,Leonidas Stamatatos,Yongcong Tan,Milan T. Tomic,Marit J. van Gils,Sawsan Youssef,Jian Yu,Tom Z. Yuan,Qian Zhang,Bjoern Peters,Georgia D. Tomaras,Timothy C. Germann,Erica Ollmann Saphire +73 more
TL;DR: Antibody-based therapeutics and vaccines are essential to combat COVID-19 morbidity and mortality after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as discussed by the authors.
Journal ArticleDOI
Ongoing global and regional adaptive evolution of SARS-CoV-2.
Nash D. Rochman,Yuri I. Wolf,Guilhem Faure,Pascal Mutz,Feng Zhang,Feng Zhang,Eugene V. Koonin +6 more
TL;DR: In this paper, the authors analyzed more than 300,000 high-quality genome sequences of SARS-CoV-2 variants available as of January 2021, and found that the ongoing evolution of CoV2 during the COVID-19 pandemic is characterized primarily by purifying selection, but a small set of sites appear to evolve under positive selection.
Journal ArticleDOI
The Lancet Commission on lessons for the future from the COVID-19 pandemic
TL;DR: The COVID-19 Commission report as mentioned in this paper provides a conceptual framework for understanding pandemics and proposes guideposts for strengthening the multilateral system to address global emergencies and to achieve sustainable development.
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus.
Bette T. Korber,Will Fischer,Sandrasegaram Gnanakaran,Hyejin Yoon,James Theiler,Werner Abfalterer,Nick Hengartner,Elena E. Giorgi,Tanmoy Bhattacharya,Brian T. Foley,Kathryn M. Hastie,Matthew Parker,David G Partridge,Cariad Evans,Timothy M. Freeman,Thushan I de Silva,Adrienne Angyal,Rebecca Brown,Laura Carrilero,Luke R. Green,Luke R. Green,Luke R. Green,Danielle C. Groves,Katie Johnson,Alexander J Keeley,Benjamin B Lindsey,Paul J. Parsons,Mohammad Raza,Sarah Rowland-Jones,Nikki Smith,Rachel Tucker,Dennis Wang,Matthew Wyles,Charlene McDanal,Lautaro G. Perez,Haili Tang,Alex Moon-Walker,Alex Moon-Walker,Alex Moon-Walker,Sean P. J. Whelan,Celia C. LaBranche,Erica Ollmann Saphire,David C. Montefiori +42 more
TL;DR: A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic, and it is found that the G614 variant grows to higher titer as pseudotyped virions.
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