Journal ArticleDOI
Targeting TRK family proteins in cancer.
Yekaterina B. Khotskaya,Vijaykumar Holla,Anna F. Farago,Kenna R. Mills Shaw,Funda Meric-Bernstam,David S. Hong +5 more
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TLDR
Selective inhibition of TRK signaling may be beneficial among patients whose tumors vary in histologies, but share underlying oncogenic NTRK gene alterations, as well as several TRK‐targeting compounds in clinical development.About:
This article is published in Pharmacology & Therapeutics.The article was published on 2017-05-01. It has received 193 citations till now. The article focuses on the topics: Trk receptor & Entrectinib.read more
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Atorvastatin inhibits pancreatic cancer cells proliferation and invasion likely by suppressing neurotrophin receptor signaling
TL;DR: Evidence is provided that atorvastatin inhibits the proliferation, migration and invasion ability of human PC cells, and atorVastatin may exert the anti-tumor effect in PC via the inhibition of neurotrophin signaling pathway.
Journal ArticleDOI
Gonadotropin Stimulation Has Only a Limited Effect on the Concentration of Follicular Fluid Signalling Proteins: An Antibody Array Analysis.
TL;DR: In this article, the effect of gonadotropin stimulation on a broad spectrum of signalling proteins was analyzed in women undergoing both treatments NC-IVF and cIVF using proteomic antibody arrays.
Journal ArticleDOI
Tropomyosin receptor kinase: a novel target in screened neuroendocrine tumors.
Elke Tatjana Aristizabal Prada,Vera Heinzle,Thomas Knösel,Svenja Nölting,Gerald Spöttl,Julian Maurer,Christine Spitzweg,Martin K. Angele,Nina Schmidt,Felix Beuschlein,Felix Beuschlein,Günter K. Stalla,Rainer Blaser,Klaus A. Kuhn,Christoph J. Auernhammer +14 more
TL;DR: It is demonstrated that the pan-Trk inhibitor GNF-5837 has promising anti-tumoral properties in human NET cell lines expressing the TrkA receptor.
Journal ArticleDOI
Autism-specific PTEN p.Ile135Leu variant and an autism genetic background combine to dysregulate cortical neurogenesis.
TL;DR: In this article , using isogenic induced pluripotent stem cell (iPSC)-derived neural progenitor cells (NPCs) and cortical organoid models, a heterozygous PTEN c.403A>C (p.Ile135Leu) variant was found in an ASD-affected individual with macrocephaly dysregulates cortical neurogenesis.
Journal ArticleDOI
NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas.
Nathan Dahl,Nathan Dahl,Andrew M. Donson,Bridget Sanford,Dong Wang,Faye M. Walker,Ahmed Gilani,Nicholas K. Foreman,Christopher L. Tinkle,Suzanne J. Baker,Lindsey Hoffman,Sujatha Venkataraman,Rajeev Vibhakar +12 more
TL;DR: In this article, NTRK1/2/3 fusions are found in a broad range of pediatric cancers, including high grade gliomas and a subset of DMGs, and a combination of single-cell and bulk transcriptome sequencing from TRK fusion-positive DMG is employed to describe the phenotypic consequences of this cooccurring alteration.
References
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Journal ArticleDOI
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
Jianjiong Gao,Bulent Arman Aksoy,Ugur Dogrusoz,Gideon Dresdner,Benjamin Gross,S. Onur Sumer,Yichao Sun,Anders Jacobsen,Rileen Sinha,Erik Larsson,Ethan Cerami,Chris Sander,Nikolaus Schultz +12 more
TL;DR: A practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics, which makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries.
Journal ArticleDOI
The trk proto-oncogene encodes a receptor for nerve growth factor.
TL;DR: The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor.
Journal ArticleDOI
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by ngf
TL;DR: Tyrosine phosphorylation of trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF.
Journal ArticleDOI
Normal development of brain circuits.
Gregory Tau,Bradley S. Peterson +1 more
TL;DR: To contextualize the developmental origins of a wide array of neuropsychiatric illnesses, this review describes the development and maturation of neural circuits from the first synapse through critical periods of vulnerability and opportunity to the emergent capacity for cognitive and behavioral regulation, and finally the dynamic interplay across levels of circuit organization and developmental epochs.
Journal ArticleDOI
The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
Gang Wu,Alexander K. Diaz,Alexander K. Diaz,Barbara S. Paugh,Sherri Rankin,Bensheng Ju,Yongjin Li,Xiaoyan Zhu,Chunxu Qu,Xiang Chen,Junyuan Zhang,John Easton,Michael N. Edmonson,Xiaotu Ma,Charles Lu,Panduka Nagahawatte,Erin Hedlund,Michael Rusch,Stanley Pounds,Tong Lin,Arzu Onar-Thomas,Robert Huether,Richard W. Kriwacki,Matthew Parker,Pankaj Gupta,Jared Becksfort,Lei Wei,Heather L. Mulder,Kristy Boggs,Bhavin Vadodaria,Donald Yergeau,Jake C. Russell,Kerri Ochoa,Robert S. Fulton,Lucinda Fulton,Chris Jones,Frederick A. Boop,Alberto Broniscer,Cynthia Wetmore,Amar Gajjar,Li Ding,Elaine R. Mardis,Richard K. Wilson,Michael R. Taylor,James R. Downing,David W. Ellison,Jinghui Zhang,Suzanne J. Baker,Suzanne J. Baker +48 more
TL;DR: In this article, the authors analyzed 127 pediatric HGGs, including diffuse intrinsic pontine gliomas (DIPGs) and non-brainstem HGG (NBS-HGGs), by whole-genome, whole-exome and/or transcriptome sequencing.
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TRKing Down an Old Oncogene in a New Era of Targeted Therapy
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Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.
Aria Vaishnavi,Marzia Capelletti,Anh T. Le,Severine Kako,Mohit Butaney,Dalia Ercan,Sakshi Mahale,Kurtis D. Davies,Dara L. Aisner,Dara L. Aisner,Amanda B. Pilling,Eamon M. Berge,Jhingook Kim,Hidefumi Sasaki,Seung-Il Park,Gregory V. Kryukov,Levi A. Garraway,Levi A. Garraway,Peter S. Hammerman,Julia Haas,Steven W. Andrews,Doron Lipson,Philip J. Stephens,V.A. Miller,Marileila Varella-Garcia,Marileila Varella-Garcia,Pasi A. Jänne,Robert C. Doebele,Robert C. Doebele +28 more