Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Daniel B. Larremore,Bryan Wilder,Evan Lester,Evan Lester,Soraya Shehata,Soraya Shehata,James M. Burke,James A. Hay,Milind Tambe,Michael J. Mina,Michael J. Mina,Roy Parker +11 more
TLDR
It is demonstrated that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity, and should prioritize accessibility, frequency, and sample-to-answer time.Abstract:
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the reopening of societies and the control of virus spread will be facilitated by robust population screening, for which virus testing will often be central. After infection, individuals undergo a period of incubation during which viral titers are too low to detect, followed by exponential viral growth, leading to peak viral load and infectiousness and ending with declining titers and clearance. Given the pattern of viral load kinetics, we model the effectiveness of repeated population screening considering test sensitivities, frequency, and sample-to-answer reporting time. These results demonstrate that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity. We therefore conclude that screening should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary.read more
Citations
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Journal ArticleDOI
COVID-19: a review of current knowledge regarding exposure, quarantine, isolation and other preventive measures
TL;DR: In this paper, the authors explore some of the pertinent knowledge gaps, while overall looking to effective vaccination strategies as a way out, early on, such strategies may need to rely on counting the convalescents as protected in order to speed up the immunization of the whole population.
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Routine Asymptomatic Testing Strategies for Airline Travel During the COVID-19 Pandemic: A Simulation Analysis (preprint)
Mathew V. Kiang,Elizabeth T Chin,Benjamin Q. Huynh,Lloyd A. C. Chapman,Rodríguez-Barraquer, Isabel, Greenhouse, Bryan, Rutherford, George W.,Rodríguez-Barraquer, Isabel, Greenhouse, Bryan, Rutherford, George W.,Bibbins-Domingo, Kirsten, Havlir, Diane, Basu, Sanjay, Lo, Nathan C.,Bibbins-Domingo, Kirsten, Havlir, Diane, Basu, Sanjay, Lo, Nathan C. +7 more
TL;DR: Routine asymptomatic testing for COVID-19 prior to travel can be an effective strategy to reduce individual risk of SARS-CoV-2 infection during travel, although post-travel testing with abbreviated quarantine is likely needed to reduce population-level transmission due to importation of infection when traveling from a high to low incidence setting.
Journal ArticleDOI
Controlling the COVID-19 Pandemic Blindly: Silent Spread in Absence of Rapid Viral Screening.
Posted ContentDOI
ADESSO detects SARS-CoV-2 and its variants: extensive clinical validation of an optimised CRISPR-Cas13-based COVID-19 test
Casati B,Verdi Jp,Hempelmann A,Kittel M,Klaebisch Ag,Welker S,Asthana S,Boskovic P,Man Kh,Radlwimmer B,Stebbins Ce,Thomas Miethke,Papavasiliou Fn,Pecori R +13 more
TL;DR: ADESSO (Accurate Detection of Evolving SARS-CoV-2 through SHERLOCK Optimisation) as discussed by the authors is an optimized version of the CRISPR-based ShERLOCK (Specific High-sensitivity Enzymatic Reporter unLOCKing) assay, which has a sensitivity of 96% and a specificity of 100% on extracted RNA.
Journal ArticleDOI
In the long shadow of our best intentions: Model-based assessment of the consequences of school reopening during the COVID-19 pandemic.
Kaitlyn E. Johnson,Madison Stoddard,Ryan P. Nolan,Douglas A.E. White,Natasha S. Hochberg,Arijit Chakravarty +5 more
TL;DR: In this article, the feasibility and consequences of school reopening in the face of differing rates of COVID-19 prevalence and transmission were explored, and it was shown that the benefits of in-person learning are numerous, including education quality, mental health, emotional well-being, equity and access to food and shelter.
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