Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Daniel B. Larremore,Bryan Wilder,Evan Lester,Evan Lester,Soraya Shehata,Soraya Shehata,James M. Burke,James A. Hay,Milind Tambe,Michael J. Mina,Michael J. Mina,Roy Parker +11 more
TLDR
It is demonstrated that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity, and should prioritize accessibility, frequency, and sample-to-answer time.Abstract:
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the reopening of societies and the control of virus spread will be facilitated by robust population screening, for which virus testing will often be central. After infection, individuals undergo a period of incubation during which viral titers are too low to detect, followed by exponential viral growth, leading to peak viral load and infectiousness and ending with declining titers and clearance. Given the pattern of viral load kinetics, we model the effectiveness of repeated population screening considering test sensitivities, frequency, and sample-to-answer reporting time. These results demonstrate that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity. We therefore conclude that screening should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary.read more
Citations
More filters
Posted ContentDOI
Sequence-specific capture and concentration of viral RNA by type III CRISPR system enhances diagnostic
Anna Nemudraia,Artem Nemudryi,Murat Buyukyoruk,Andrew M. Scherffius,Trevor Zahl,Tanner Wiegand,Shishir Pandey,Joseph Nichols,Laina Hall,Aidan McVey,Helen H Lee,Royce A. Wilkinson,Laura Snyder,Joshua D. Jones,Kristin S. Koutmou,Andrew Santiago-Frangos,Blake Wiedenheft +16 more
TL;DR: In this paper , the type-III-A CRISPR-Cas system was used for sequence-specific detection of SARS-CoV-2 RNA from nasopharyngeal swab samples.
Journal ArticleDOI
Overlapping timescales obscure early warning signals of the second COVID-19 wave
TL;DR: In this article , the authors studied whether early warning indicators could reliably predict the second COVID-19 wave in European countries, and they found that characteristic early-warning indicators generally decreased rather than increased prior to the second wave.
Journal ArticleDOI
Feasibility and utility of facemask sampling in the detection of SARS-CoV-2 during an ongoing pandemic.
Dorothy Hui Lin Ng,Mei Yi Sim,Hong Hong Huang,Jean Xiang Ying Sim,Jenny G. Low,Jenny G. Low,Jay Kheng Sit Lim +6 more
TL;DR: In this paper, the authors used a prototype of Steri-Strips™ (3M) applied to the inner surface of looped surgical facemasks (Assure), which was worn by patients for a minimum wear time of 3h, then removed and sent for SARS-CoV-2 PCR testing.
Journal ArticleDOI
Monoclonal antibody pairs against SARS-CoV-2 for rapid antigen test development
TL;DR: The results suggest that the rapid antigen test is optimized to detect SARS-CoV-2 N during the acute phase of COVID-19.
Journal ArticleDOI
Time variation in the probability of failing to detect a case of polymerase chain reaction testing for SARS-CoV-2 as estimated from a viral dynamics model.
Keisuke Ejima,Kwang Su Kim,Shoya Iwanami,Yasuhisa Fujita,Ming Li,Roger S. Zoh,Kazuyuki Aihara,Taiga Miyazaki,Takaji Wakita,Shingo Iwami +9 more
TL;DR: In this article, the authors used a viral dynamics model to track the probability of failing to detect a case of COVID-19 infection over time, including the presymptomatic period.
References
More filters
Journal ArticleDOI
Virological assessment of hospitalized patients with COVID-2019.
Roman Wölfel,Victor M. Corman,Wolfgang Guggemos,M Seilmaier,Sabine Zange,Marcel A. Müller,Daniela Niemeyer,Terry Jones,Terry Jones,Patrick Vollmar,Camilla Rothe,Michael Hoelscher,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Rosina Ehmann,Katrin Zwirglmaier,Christian Drosten,Clemens M. Wendtner +18 more
TL;DR: Detailed virological analysis of nine cases of coronavirus disease 2019 (COVID-19) provides proof of active replication of the SARS-CoV-2 virus in tissues of the upper respiratory tract.
Journal ArticleDOI
The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application.
Stephen A. Lauer,Kyra H. Grantz,Qifang Bi,Forrest K. Jones,Qulu Zheng,Hannah R. Meredith,Andrew S. Azman,Nicholas G. Reich,Justin Lessler +8 more
TL;DR: The results support current proposals for the length of quarantine or active monitoring of persons potentially exposed to SARS-CoV-2, although longer monitoring periods might be justified in extreme cases.
Journal ArticleDOI
Temporal dynamics in viral shedding and transmissibility of COVID-19.
Xi He,Eric H. Y. Lau,Peng Wu,Xilong Deng,Jian Wang,Xinxin Hao,Yiu Chung Lau,Jessica Y. Wong,Yujuan Guan,Xinghua Tan,Xiaoneng Mo,Yanqing Chen,Baolin Liao,Weilie Chen,Fengyu Hu,Qing Zhang,Mingqiu Zhong,Yanrong Wu,Lingzhai Zhao,Fuchun Zhang,Benjamin J. Cowling,Fang Li,Gabriel M. Leung +22 more
TL;DR: It is estimated that 44% (95% confidence interval, 25–69%) of secondary cases were infected during the index cases’ presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home.
Journal ArticleDOI
Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study.
Kelvin K. W. To,Owen Tak Yin Tsang,Wai Shing Leung,Anthony Raymond Tam,Tak Chiu Wu,David Christopher Lung,Cyril C. Y. Yip,Jian Piao Cai,Jacky Man Chun Chan,Thomas Shiu Hong Chik,Daphne Pui-Ling Lau,Chris Yau Chung Choi,Lin Lei Chen,Wan Mui Chan,Kwok-Hung Chan,Jonathan Daniel Ip,Anthony Chin-Ki Ng,Rosana W.S. Poon,Cui Ting Luo,Vincent C.C. Cheng,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Ivan Hung,Zhiwei Chen,Honglin Chen,Kwok-Yung Yuen +25 more
TL;DR: The serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal saliva samples from patients with COVID-19, and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 are ascertained.
Journal ArticleDOI
Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR
TL;DR: In a series of 51 patients with chest CT and real-time polymerase chain reaction assay (RT-PCR) performed within 3 days, the sensitivity of CT for 2019 novel coronavirus infection was 98% and that ...
Related Papers (5)
Virological assessment of hospitalized patients with COVID-2019.
Roman Wölfel,Victor M. Corman,Wolfgang Guggemos,M Seilmaier,Sabine Zange,Marcel A. Müller,Daniela Niemeyer,Terry Jones,Terry Jones,Patrick Vollmar,Camilla Rothe,Michael Hoelscher,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Rosina Ehmann,Katrin Zwirglmaier,Christian Drosten,Clemens M. Wendtner +18 more
Temporal dynamics in viral shedding and transmissibility of COVID-19.
Prevalence of Asymptomatic SARS-CoV-2 Infection : A Narrative Review.
Daniel P Oran,Eric J. Topol +1 more
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.
Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more