Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening.
Daniel B. Larremore,Bryan Wilder,Evan Lester,Evan Lester,Soraya Shehata,Soraya Shehata,James M. Burke,James A. Hay,Milind Tambe,Michael J. Mina,Michael J. Mina,Roy Parker +11 more
TLDR
It is demonstrated that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity, and should prioritize accessibility, frequency, and sample-to-answer time.Abstract:
The COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the reopening of societies and the control of virus spread will be facilitated by robust population screening, for which virus testing will often be central. After infection, individuals undergo a period of incubation during which viral titers are too low to detect, followed by exponential viral growth, leading to peak viral load and infectiousness and ending with declining titers and clearance. Given the pattern of viral load kinetics, we model the effectiveness of repeated population screening considering test sensitivities, frequency, and sample-to-answer reporting time. These results demonstrate that effective screening depends largely on frequency of testing and speed of reporting and is only marginally improved by high test sensitivity. We therefore conclude that screening should prioritize accessibility, frequency, and sample-to-answer time; analytical limits of detection should be secondary.read more
Citations
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Economic Benefits of COVID-19 Screening Tests with a Vaccine Rollout
TL;DR: In this paper, the authors estimate the costs and benefits of a nationwide COVID-19 screening testing program in the presence of vaccine distribution and show that a well-designed federally-funded screening testing, coupled with self-isolation of those who test positive, pays for itself in terms of increased GDP and is projected to save 20,000 or more lives.
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An optimized stepwise algorithm combining rapid antigen and RT-qPCR for screening of COVID-19 patients.
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TL;DR: In this article, the combination of rapid antigen detection (RAD) and RT-qPCR assays in a stepwise procedure was investigated to optimize the detection of COVID-19.
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Geographic and demographic heterogeneity of SARS-CoV-2 diagnostic testing in Illinois, USA, March to December 2020
Tobias M Holden,Reese A.K. Richardson,Philip Arevalo,Wayne A Duffus,Wayne A Duffus,Manuela Runge,Elena Whitney,Leslie Wise,Ngozi O Ezike,Sarah Patrick,Sarah Cobey,Jaline Gerardin +11 more
TL;DR: In this paper, the authors compared SARS-CoV-2 testing rates across geographic regions, over time, and by demographic characteristics (i.e., age and racial/ethnic groups) in Illinois during March through December 2020.
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Bacterial lifestyle switch in response to algal metabolites
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Preventing COVID-19 outbreaks through surveillance testing in healthcare facilities: a modelling study
TL;DR: In this article , the authors established an individual-based model representative of a mental health hospital yielding generalizable results and concluded that active testing in mental health hospitals and similar facilities considerably reduces the number of COVID-19 outbreaks compared to symptom-based surveillance only.
References
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