Journal ArticleDOI
The antiviral activities of TRIM proteins.
TLDR
The latest discoveries on the molecular mechanisms of antiviral TRIM proteins are summarized and the current and future trends in this fast-evolving field are discussed.About:
This article is published in Current Opinion in Microbiology.The article was published on 2021-02-01. It has received 49 citations till now. The article focuses on the topics: Tripartite motif family & Tripartite Motif Proteins.read more
Citations
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Journal ArticleDOI
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Manuel Hayn,Maximilian Hirschenberger,Lennart Koepke,Rayhane Nchioua,Jan Hendrik Straub,Susanne Klute,Victoria Hunszinger,Fabian Zech,Caterina Prelli Bozzo,Wasim Aftab,Maria H Christensen,Carina Conzelmann,Janis A. Müller,Smitha Srinivasachar Badarinarayan,Christina M. Stürzel,Ignasi Forné,Steffen Stenger,Karl-Klaus Conzelmann,Jan Münch,Florian I. Schmidt,Daniel Sauter,Axel Imhof,Frank Kirchhoff,Konstantin Maria Johannes Sparrer +23 more
TL;DR: In this article, the authors systematically analyzed the impact of SARS-CoV-2 proteins on interferon (IFN) responses and autophagy, and they showed that SARS co-virus 2 proteins synergize to counteract anti-viral immune responses.
Journal ArticleDOI
TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation
Suyan Wang,Mengmeng Yu,Aijing Liu,Yuanling Bao,Xiaole Qi,Li Gao,Yuntong Chen,Peng Liu,Yulong Wang,Lixiao Xing,Lingzhai Meng,Yu Zhang,Linjin Fan,Xinyi Li,Qing Pan,Yanping Zhang,Hongyu Cui,Kai Li,Changjun Liu,Xijun He,Yulong Gao,Xiaomei Wang,Xiaomei Wang +22 more
TL;DR: In this paper, the authors conducted RNA-seq in avian cells infected by IBDV and identified TRIM25 as a host restriction factor, and demonstrated that the ubiquitination site of VP3 was the key target site for the catalyzed degradation.
Journal ArticleDOI
Interferon antagonists encoded by SARS-CoV-2 at a glance
TL;DR: In this article , the authors review the molecular mechanisms used by SARS-CoV-2 proteins to suppress IFN production and the establishment of an anti-viral state.
Journal ArticleDOI
The Function of the PRRSV–Host Interactions and Their Effects on Viral Replication and Propagation in Antiviral Strategies
TL;DR: In this article, the authors review the complex network and the mechanism of PRRSV-host interactions in the processes of virus infection, and develop novel antiviral strategies against PRRSVs by studying these host-virus interactions and structures to better understand the molecular mechanisms of virus immune escape.
Journal ArticleDOI
Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape.
Li-Jie Yao,Liqing Xu,Li-Juan Zhou,Shuizhen Wu,Wei-Hao Zou,Min Chen,Jia-Ting Chen,Hong-Juan Peng +7 more
TL;DR: In this paper, the authors found that T gondii virulence factor ROP18 of the type I RH strain (TgROP18I) interacted with human TRIM21, and promoted the latter's phosphorylation, which subsequently accelerated the degradation through lysosomal pathway.
References
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Journal ArticleDOI
The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.
Matthew Stremlau,Christopher M. Owens,Michel Perron,Michael Kiessling,Patrick Autissier,Joseph Sodroski +5 more
TL;DR: Host cell barriers to the early phase of immunodeficiency virus replication explain the current distribution of these viruses among human and non-human primate species and reveal host cell components that modulate the uncoating of a retroviral capsid.
Journal ArticleDOI
Trim5α protein restricts both HIV-1 and murine leukemia virus
TL;DR: It is hypothesized that the Trim family of proteins plays a widespread role in innate immunity to viral infection and that human, rhesus, and African green monkey Trim5α can restrict N-MLV.
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A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 Restriction
TL;DR: A single amino acid substitution in the human Trim5alpha can confer the ability to restrict HIV-1, suggesting that small changes during evolution may have profound effects on the authors' susceptibility to cross-species infection.
Journal ArticleDOI
Model-based assessment of the Role of Uneven Partitioning of Molecular Content on Heterogeneity and Regulation of Differentiation in CD8 T-cell Immune Responses
TL;DR: It is shown that immune response dynamics can be explained by the molecular-content heterogeneity generated by uneven partitioning at cell division, and that the degree of unevenness of molecular partitioning affects the outcome of the immune response and can promote the generation of memory cells.
Journal ArticleDOI
PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0
TL;DR: PML contributes to a cellular antiviral repression mechanism that is countered by the activity of ICP0, and it is demonstrated that depletion of PML increases both gene expression and plaque formation by an I CP0-negative HSV-1 mutant, while having no effect on wild-type HSVs.