Book ChapterDOI
The Definition and Prevalence of Obesity and Metabolic Syndrome.
TLDR
Obesity is associated with a large decrease in life expectancy, but up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically "unhealthy" obese patients.Abstract:
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy. The effect of extreme obesity on mortality is greater among younger than older adults. In this respect, obesity is also associated with increased risk of several cancer types. However, up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically “unhealthy” obese patients.read more
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Journal ArticleDOI
Metabolic Differences between Subcutaneous and Visceral Adipocytes Differentiated with an Excess of Saturated and Monounsaturated Fatty Acids
Małgorzata Małodobra-Mazur,Aneta Cierzniak,Dorota Pawełka,Krzysztof Kaliszewski,Jerzy Rudnicki,Tadeusz Dobosz +5 more
TL;DR: Oleic acid showed the strongest effect on adipogenesis and attenuated insulin signaling and secretion of cytokines and adipokines, and visceral adipose tissue was shown to be more prone to generate inflammatory stages.
Journal ArticleDOI
Do flavanols-rich natural products relieve obesity-related insulin resistance?
TL;DR: Polyphenol intake can prevent high-fat-diet-induced insulin resistance via cell surface G protein-coupled estrogen receptors by upregulating the expression of related genes, and their pathways, which are responsible for the insulin sensitivity.
Journal ArticleDOI
High-Fat Diet-Induced Obesity Model Does Not Promote Endothelial Dysfunction via Increasing Leptin/Akt/eNOS Signaling.
Vanessa da Silva Rocha,Erick Roberto Gonçalves Claudio,Vitor Loureiro da Silva,Jóctan Pimentel Cordeiro,Lucas Furtado Domingos,Márcia Regina Holanda da Cunha,Helder Mauad,Thiago Bruder do Nascimento,Ana Paula Lima-Leopoldo,André Soares Leopoldo +9 more
TL;DR: The hypothesis that unsaturated high-fat diet-induced obesity does not generate endothelial dysfunction via increasing the vascular leptin/Akt/eNOS signaling is tested, and the results suggest that the increase in NO production occurs through the increases in NOS activation by leptin and is partially mediated by the Akt pathway.
Journal ArticleDOI
Natural antioxidants' effects on endoplasmic reticulum stress-related diseases.
Laura María Reyes-Fermín,Omar Emiliano Aparicio-Trejo,Sabino Hazael Avila-Rojas,Tania Gómez-Sierra,Elena Martínez-Klimova,José Pedraza-Chaverri +5 more
TL;DR: This review is focused on the effects of natural antioxidant compounds on ER stress in endothelial dysfunction, diabetes and heart, liver, kidney or neurological diseases.
Journal ArticleDOI
The effects of nano-curcumin supplementation on glycemic control, blood pressure, lipid profile, and insulin resistance in patients with the metabolic syndrome: A randomized, double-blind clinical trial.
TL;DR: In this paper, a randomized, double-blind, controlled clinical trial, 50 patients with MetS were randomly assigned to two groups to receive either 80 mg/day nano-curcumin (n = 25) or placebo (n= 25), for 12 weeks anthropometric measurements, blood pressure, and biochemical factors-including fasting blood sugar (FBS), Hemoglobin A1c (HbA1c), homeostatic model assessment (HOMA-IR), pancreatic β cell function (HomoA-β), and lipid profile-were assessed at
References
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Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
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TL;DR: This statement from the American Heart Association and the National Heart, Lung, and Blood Institute is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults.
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