Book ChapterDOI
The Definition and Prevalence of Obesity and Metabolic Syndrome.
TLDR
Obesity is associated with a large decrease in life expectancy, but up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically "unhealthy" obese patients.Abstract:
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy. The effect of extreme obesity on mortality is greater among younger than older adults. In this respect, obesity is also associated with increased risk of several cancer types. However, up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically “unhealthy” obese patients.read more
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Journal ArticleDOI
The Association Between Fecal Short-Chain Fatty Acids, Gut Microbiota, and Visceral Fat in Monozygotic Twin Pairs
TL;DR: Low fecal concentrations of SCFAs were associated with visceral obesity, and the gut microbiota might be involved in the underlying mechanism.
Journal ArticleDOI
Influence of diet and sport on the risk of sleep apnea in patients with metabolic syndrome associated with hypothyroidism - a 4-year survey.
Timea Claudia Ghitea,Lotfi Aleya,Delia Mirela Tit,Tapan Behl,Manuela Stoicescu,Cristian Sava,Ciprian Iovan,Amina El-Kharoubi,Diana Uivarosan,Annamaria Pallag,Simona Bungau +10 more
TL;DR: In this article, the risk of obstructive sleep apnea following diet therapy and sports-associated diet therapy in patients with metabolic syndrome (MS) and hypothyroidism was monitored.
Posted ContentDOI
Identifying Causative Mechanisms Linking Early-Life Stress to Psycho-Cardio-Metabolic Multi-Morbidity: The EarlyCause Project
Nicole Mariani,Alessandra Borsini,Charlotte A.M. Cecil,Janine F. Felix,Sylvain Sebert,Annamaria Cattaneo,Esther Walton,Yuri Milaneschi,Guy Cochrane,Clara Amid,Jeena Rajan,Juliette Giacobbe,Yolanda Sanz,Ana Agusti,Tania Sorg,Yann Herault,Jouko Miettunen,Priyanka Parmar,Nadia Cattane,Vincent W. V. Jaddoe,Jyrki Lotjonen,Carme Buisan,Miguel Ángel González Ballester,Gemma Piella,Josep Lluís Gelpí,Femke Lamers,Brenda W.J.H. Penninx,Henning Tiemeier,Malte von Tottleben,Rainer Thiel,Katharina F. Heil,Marjo-Riitta Järvelin,Carmine M. Pariante,Isabelle M. Mansuy,Karim Lekadir +34 more
TL;DR: The research will mainly focus on four biological processes including possible alterations of the epigenome, neuroendocrine system, inflammatome, and the gut microbiome that will help better manage the impact of multi-morbidity on human health and the associated risk.
Journal ArticleDOI
Inhibitory kinetics and mechanism of pentacyclic triterpenoid from endophytic Colletotrichum gigasporum against pancreatic lipase
TL;DR: In this article, the authors demonstrate macromolecular interaction and inhibitory effect of pentacyclic triterpenoids (PTT) on pancreatic lipase (PL).
Journal ArticleDOI
Improvement in arterial stiffness (pOpmètre®) after bariatric surgery. Results from a prospective study
TL;DR: It is suggested that pathological arterial stiffness may resolve following bariatric surgery independently of the other factors influencing cardiovascular risk in obesity.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
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Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
William C. Taylor,Nigel Unwin +1 more
Journal Article
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Scott M. Grundy,Diane M. Becker,Luther T. Clark,Richard S. Cooper,Margo A. Denke,James P. Howard,Donald B. Hunninghake,D. Roger Illingworth,Russell V. Luepker,Patrick E. McBride,James M. McKenney,Richard C. Pasternak,Neil J. Stone,Linda Van Horn +13 more
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Diagnosis and Management of the Metabolic Syndrome An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Scott M. Grundy,James I. Cleeman,Stephen R. Daniels,Karen A. Donato,Robert H. Eckel,Barry A. Franklin,David Gordon,Ronald M. Krauss,Peter J. Savage,Sidney C. Smith,John A. Spertus,Fernando Costa +11 more
TL;DR: This statement from the American Heart Association and the National Heart, Lung, and Blood Institute is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults.
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