Book ChapterDOI
The Definition and Prevalence of Obesity and Metabolic Syndrome.
TLDR
Obesity is associated with a large decrease in life expectancy, but up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically "unhealthy" obese patients.Abstract:
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy. The effect of extreme obesity on mortality is greater among younger than older adults. In this respect, obesity is also associated with increased risk of several cancer types. However, up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically “unhealthy” obese patients.read more
Citations
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Journal ArticleDOI
Mendelian Randomization Analysis Reveals Causal Effects of the Human Gut Microbiota on Abdominal Obesity.
Qian Xu,Shan-Shan Zhang,Rui-Rui Wang,Yu-Jing Weng,Xun Cui,Xin-Tong Wei,Jing-Jing Ni,Haigang Ren,Lei Zhang,Yu-Fang Pei +9 more
TL;DR: In this article, a 2-sample Mendelian randomization (MR) analysis was performed to determine the causal relationship between specific gut microbiota and abdominal obesity, based on genome-wide association study (GWAS) summary statistics, to evaluate whether the gut microbiota affects abdominal obesity.
Journal ArticleDOI
An exploration of new methods for metabolic syndrome examination by infrared thermography and knowledge mining
Bao Mi,Wenzheng Zhang,Yong-hua Xiao,Wenxue Hong,Jia Lin Song,Jian-Feng Tu,Bi-Yao Jiang,Chen Ye,Guang-Xia Shi +8 more
TL;DR: In this paper , the authors tried to explore the differences between healthy people and MS patients through infrared thermography (IRT), and they tried to solve the observation region of the IRT image with the help of knowledge mining technology.
Journal ArticleDOI
Carotid intima-media thickness, hypertension, and dyslipidemia in obese adolescents.
Nur Aisiyah Widjaja,Roedi Irawan,Rendi Aji Prihaningtyas,Meity Ardiana,Meta Herdiana Hanindita +4 more
TL;DR: The high number of dyslipidemia and hypertension in obese adolescents need an early detection of cardiovascular complication, and no difference of CIMT based on gender between adolescents aged below 18 is found.
Journal ArticleDOI
The Metabolic Efficacy of a Cannabidiolic Acid (CBDA) Derivative in Treating Diet- and Genetic-Induced Obesity
Elad Ben-Cnaan,Anna Permyakova,Shahar Azar,Shira Hirsch,Saja Baraghithy,Liad Hinden,Joseph Tam +6 more
TL;DR: Results support the idea to further promote this synthetic CBDA derivative toward clinical evaluation in humans, and show that EPM301 ameliorated obesity and its metabolic abnormalities in both DIO and GIO.
Journal ArticleDOI
Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis.
Pallavi Rai,Christina Chuong,Tanya LeRoith,James W. Smyth,Julia Panov,Moshe Levi,Kylene Kehn-Hall,Nisha K. Duggal,James-Weger Lucarelli +8 more
TL;DR: In this paper, the effect of obesity on disease severity following SARS-CoV-2 infection using a well-established mouse model of diet-induced obesity was investigated, and significant weight loss was observed in obese mice treated with the adenovirus vector.
References
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
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Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
William C. Taylor,Nigel Unwin +1 more
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Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Scott M. Grundy,Diane M. Becker,Luther T. Clark,Richard S. Cooper,Margo A. Denke,James P. Howard,Donald B. Hunninghake,D. Roger Illingworth,Russell V. Luepker,Patrick E. McBride,James M. McKenney,Richard C. Pasternak,Neil J. Stone,Linda Van Horn +13 more
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Diagnosis and Management of the Metabolic Syndrome An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Scott M. Grundy,James I. Cleeman,Stephen R. Daniels,Karen A. Donato,Robert H. Eckel,Barry A. Franklin,David Gordon,Ronald M. Krauss,Peter J. Savage,Sidney C. Smith,John A. Spertus,Fernando Costa +11 more
TL;DR: This statement from the American Heart Association and the National Heart, Lung, and Blood Institute is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults.
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