Book ChapterDOI
The Definition and Prevalence of Obesity and Metabolic Syndrome.
TLDR
Obesity is associated with a large decrease in life expectancy, but up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically "unhealthy" obese patients.Abstract:
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy. The effect of extreme obesity on mortality is greater among younger than older adults. In this respect, obesity is also associated with increased risk of several cancer types. However, up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically “unhealthy” obese patients.read more
Citations
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Journal ArticleDOI
Epidemiology, aetiology, and management of ischaemic stroke in young adults
Merel S. Ekker,Esther M. Boot,Aneesh B. Singhal,Kay Sin Tan,Stéphanie Debette,Anil M. Tuladhar,Frank-Erik de Leeuw +6 more
TL;DR: Progress has been made in identifying patients with a considerable risk of stroke occurrence, such as those with patent foramen ovale, and future prevention studies might result in a decrease in the incidence of stroke and its sequelae in young adults.
Journal ArticleDOI
Multimorbidity Trends in United States Adults, 1988-2014.
TL;DR: Multimorbidity is common and has been increasing over the last 25 years, which has implications for public health policy and anticipated health costs for the coming years.
Journal ArticleDOI
Dietary polyphenols to combat the metabolic diseases via altering gut microbiota
TL;DR: Although, there are numerous studies defines the effective role of PPs against MD via altering the GM, a significant research effort is still needed to consider PPs as promising nutraceuticals against MD.
Journal ArticleDOI
Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota.
Umair Shabbir,Momna Rubab,Eric Banan-Mwine Daliri,Ramachandran Chelliah,Ahsan Javed,Deog-Hwan Oh +5 more
TL;DR: In this article, the structural changes that occur after metabolic reactions in polyphenols (curcumin, quercetin, and catechins) and their effect on GM composition were investigated.
Journal ArticleDOI
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action.
Bahare Salehi,Javad Sharifi-Rad,Francesca Cappellini,Željko Reiner,Debora Zorzan,Muhammad Imran,Bilge Sener,Mehtap Kilic,Mohamed El-Shazly,Mohamed El-Shazly,Nouran M. Fahmy,Eman Al-Sayed,Miquel Martorell,Chiara Tonelli,Katia Petroni,Anca Oana Docea,Daniela Calina,Alfred Maroyi +17 more
TL;DR: An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.
References
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Journal ArticleDOI
Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories: A Systematic Review and Meta-analysis
TL;DR: A systematic review of reported hazard ratios (HRs) of all-cause mortality for overweight and obesity relative to normal weight in the general population found that both obesity (all grades) and grades 2 and 3 obesity were associated with significantly higher all- cause mortality.
Journal ArticleDOI
Childhood obesity: public-health crisis, common sense cure
TL;DR: In view of its rapid development in genetically stable populations, the childhood obesity epidemic can be primarily attributed to adverse environmental factors for which straightforward, if politically difficult, solutions exist.
Journal ArticleDOI
Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study.
Caroline S. Fox,Joseph M. Massaro,Udo Hoffmann,Karla M. Pou,Pál Maurovich-Horvat,Chunyu Liu,Ramachandran S. Vasan,Joanne M. Murabito,James B. Meigs,L. Adrienne Cupples,Ralph B. D'Agostino,Christopher J. O'Donnell +11 more
TL;DR: These findings are consistent with the hypothesized role of visceral fat as a unique, pathogenic fat depot and Measurement of VAT may provide a more complete understanding of metabolic risk associated with variation in fat distribution.
Journal ArticleDOI
Health and economic burden of the projected obesity trends in the USA and the UK
TL;DR: A simulation model used to project the probable health and economic consequences in the next two decades from a continued rise in obesity in two ageing populations--the USA and the UK used to find that effective policies to promote healthier weight also have economic benefits.
Journal ArticleDOI
Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity.
Tim J Cole,Tim Lobstein +1 more
TL;DR: The international (International Obesity Task Force; IOTF) body mass index cut‐offs are widely used to assess the prevalence of child overweight, obesity and thinness and based on data from six countries fitted by the LMS method, they link BMI values at 18 years to child centiles, which are averaged across the countries.
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