Book ChapterDOI
The Definition and Prevalence of Obesity and Metabolic Syndrome.
TLDR
Obesity is associated with a large decrease in life expectancy, but up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically "unhealthy" obese patients.Abstract:
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy. The effect of extreme obesity on mortality is greater among younger than older adults. In this respect, obesity is also associated with increased risk of several cancer types. However, up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically “unhealthy” obese patients.read more
Citations
More filters
Journal ArticleDOI
Overweight/obesity in adolescents with phenylketonuria: protective and predisposing factors
TL;DR: In this article , anthropometric measurements, serum phenylalanine levels, and 10 metabolites associated with lipid and carbohydrate metabolism were analyzed in 101 adolescents aged 10-20 years and the prevalence of overweight/obesity in adolescents was 27.7%.
Journal ArticleDOI
Untargeted Metabolomic Approach Shows No Differences in Subcutaneous Adipose Tissue of Diabetic and Non-Diabetic Subjects Undergoing Bariatric Surgery: An Exploratory Study.
TL;DR: Comparison of the untargeted metabolomic profiles of diabetic and non-diabetic obese patients undergoing bariatric surgery found that obesity may influence SAT metabolism masking T2DM-dependent dysregulation.
Journal ArticleDOI
Effects of Obesity on Reparative Function of Human Adipose Tissue-Derived Mesenchymal Stem Cells on Ischemic Murine Kidneys
Nattawat Klomjit,Sabena M. Conley,Xiangyang Zhu,Ishran M. Sadiq,Yaara Libai,James D. Krier,Christopher M. Ferguson,Kyra L. Jordan,Huiqiong Tang,Amir Lerman,Lilach O. Lerman +10 more
TL;DR: In this paper , abdominal adipose tissue-derived mesenchymal stem/stromal cells (MSCs) were harvested from patients without (lean) or with obesity (obese) during kidney donation or bariatric surgery, respectively.
Journal ArticleDOI
Obesity: The Fat Tissue Disease Version of Cancer
TL;DR: The ideas proposed herein could have utility to sensitize the public opinion about the hard reality of obesity, which merits a top position among the most lethal diseases besides cancer.
Journal ArticleDOI
Identifying causative mechanisms linking early-life stress to psycho-cardio-metabolic multi-morbidity: The EarlyCause project
Nicole Mariani,Alessandra Borsini,Charlotte A.M. Cecil,Janine F. Felix,Sylvain Sebert,Sylvain Sebert,Sylvain Sebert,Annamaria Cattaneo,Esther Walton,Yuri Milaneschi,Guy Cochrane,Clara Amid,Clara Amid,Jeena Rajan,Juliette Giacobbe,Yolanda Sanz,Ana Agusti,Tania Sorg,Yann Herault,Jouko Miettunen,Priyanka Parmar,Nadia Cattane,Vincent W. V. Jaddoe,Jyrki Lotjonen,Carme Buisan,Miguel Ángel González Ballester,Miguel Ángel González Ballester,Gemma Piella,Josep Lluís Gelpí,Femke Lamers,Brenda W.J.H. Penninx,Henning Tiemeier,Malte von Tottleben,Rainer Thiel,Katharina F. Heil,Marjo-Riitta Järvelin,Carmine M. Pariante,Isabelle M. Mansuy,Karim Lekadir +38 more
TL;DR: The EarlyCause project as discussed by the authors, a large-scale and inter-disciplinary research project funded by the European Union's Horizon 2020 research and innovation programme, takes advantage of human longitudinal birth cohort data, animal studies and cellular models to test the hypothesis of shared mechanisms and molecular pathways by which early life stress shapes an individual's physical and mental health in adulthood.
References
More filters
Journal ArticleDOI
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Journal ArticleDOI
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.
K. G. M. M. Alberti,Paul Zimmet +1 more
TL;DR: A WHO Consultation has taken place in parallel with a report by an American Diabetes Association Expert Committee to re‐examine diagnostic criteria and classification of diabetes mellitus and is hoped that the new classification will allow better classification of individuals and lead to fewer therapeutic misjudgements.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Detection, Evaluation, and Treatment of High Blood Cholesterol Education Program (NCEP) Expert Panel on Executive Summary of the Third Report of the National
William C. Taylor,Nigel Unwin +1 more
Journal Article
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Scott M. Grundy,Diane M. Becker,Luther T. Clark,Richard S. Cooper,Margo A. Denke,James P. Howard,Donald B. Hunninghake,D. Roger Illingworth,Russell V. Luepker,Patrick E. McBride,James M. McKenney,Richard C. Pasternak,Neil J. Stone,Linda Van Horn +13 more
Journal ArticleDOI
Diagnosis and Management of the Metabolic Syndrome An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
Scott M. Grundy,James I. Cleeman,Stephen R. Daniels,Karen A. Donato,Robert H. Eckel,Barry A. Franklin,David Gordon,Ronald M. Krauss,Peter J. Savage,Sidney C. Smith,John A. Spertus,Fernando Costa +11 more
TL;DR: This statement from the American Heart Association and the National Heart, Lung, and Blood Institute is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults.
Related Papers (5)
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
Scott M. Grundy,David W. Bilheimer,Alan Chait,Luther T. Clark,Margo A. Denke,Richard J. Havel,William R. Hazzard,Stephen B. Hulley,Donald B. Hunninghake,Robert A. Kreisberg,Penny M. Kris-Etherton,James M. McKenney,Michael A. Newman,Ernst J. Schaefer,Burton E. Sobel,Carolyn Somelofski,Milton C. Weinstein,H. Bryan Brewer,James I. Cleeman,Karen A. Donato,Nancy D. Ernst,Jeffrey M. Hoeg,Basil M. Rifkind,Jacques E. Rossouw,Christopher T. Sempos,Joanne M. Gallivan,Maureen N. Harris,Laurie Quint-Adler +27 more
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013
Marie Ng,Tom P Fleming,Margaret Robinson,Blake Thomson,Nicholas Graetz,Christopher Margono,Erin C Mullany,Stan Biryukov,Cristiana Abbafati,Semaw Ferede Abera,Jerry Abraham,Niveen M E Abu-Rmeileh,Tom Achoki,Fadia AlBuhairan,Zewdie Aderaw Alemu,Rafael Alfonso,Mohammed K. Ali,Raghib Ali,Nelson Alvis Guzmán,Walid Ammar,Palwasha Anwari,Amitava Banerjee,Simón Barquera,Sanjay Basu,Derrick A Bennett,Zulfiqar A Bhutta,Jed D. Blore,N Cabral,Ismael Ricardo Campos Nonato,Jung-Chen Chang,Rajiv Chowdhury,Karen J. Courville,Michael H. Criqui,David K. Cundiff,Kaustubh Dabhadkar,Lalit Dandona,Lalit Dandona,Adrian Davis,Anand Dayama,Samath D Dharmaratne,Eric L. Ding,Adnan M. Durrani,Alireza Esteghamati,Farshad Farzadfar,Derek F J Fay,Valery L. Feigin,Abraham D. Flaxman,Mohammad H. Forouzanfar,Atsushi Goto,Mark A. Green,Rajeev Gupta,Nima Hafezi-Nejad,Graeme J. Hankey,Heather Harewood,Rasmus Havmoeller,Simon I. Hay,Lucia Hernandez,Abdullatif Husseini,Bulat Idrisov,Nayu Ikeda,Farhad Islami,Eiman Jahangir,Simerjot K. Jassal,Sun Ha Jee,Mona Jeffreys,Jost B. Jonas,Edmond K. Kabagambe,Shams Eldin Ali Hassan Khalifa,Andre Pascal Kengne,Yousef Khader,Young-Ho Khang,Daniel Kim,Ruth W Kimokoti,Jonas Minet Kinge,Yoshihiro Kokubo,Soewarta Kosen,Gene F. Kwan,Taavi Lai,Mall Leinsalu,Yichong Li,Xiaofeng Liang,Shiwei Liu,Giancarlo Logroscino,Paulo A. Lotufo,Yuan Qiang Lu,Jixiang Ma,Nana Kwaku Mainoo,George A. Mensah,Tony R. Merriman,Ali H. Mokdad,Joanna Moschandreas,Mohsen Naghavi,Aliya Naheed,Devina Nand,K.M. Venkat Narayan,Erica Leigh Nelson,Marian L. Neuhouser,Muhammad Imran Nisar,Takayoshi Ohkubo,Samuel Oti,Andrea Pedroza,Dorairaj Prabhakaran,Nobhojit Roy,Uchechukwu K.A. Sampson,Hyeyoung Seo,Sadaf G. Sepanlou,Kenji Shibuya,Rahman Shiri,Ivy Shiue,Gitanjali M Singh,Jasvinder A. Singh,Vegard Skirbekk,Nicolas J. C. Stapelberg,Lela Sturua,Bryan L. Sykes,Martin Tobias,Bach Xuan Tran,Leonardo Trasande,Hideaki Toyoshima,Steven van de Vijver,Tommi Vasankari,J. Lennert Veerman,Gustavo Velasquez-Melendez,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Stein Emil Vollset,Theo Vos,Claire L. Wang,Xiao Rong Wang,Elisabete Weiderpass,Andrea Werdecker,Jonathan L. Wright,Y Claire Yang,Hiroshi Yatsuya,Jihyun Yoon,Seok Jun Yoon,Yong Zhao,Maigeng Zhou,Shankuan Zhu,Alan D. Lopez,Christopher J L Murray,Emmanuela Gakidou +141 more