Book ChapterDOI
The Definition and Prevalence of Obesity and Metabolic Syndrome.
TLDR
Obesity is associated with a large decrease in life expectancy, but up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically "unhealthy" obese patients.Abstract:
Increase in prevalence of obesity has become a worldwide major health problem in adults, as well as among children and adolescents. Furthermore, total adiposity and truncal subcutaneous fat accumulation during adolescence are positively and independently associated with atherosclerosis at adult ages. Centrally accumulation of body fat is associated with insulin resistance, whereas distribution of body fat in a peripheral pattern is metabolically less important. Obesity is associated with a large decrease in life expectancy. The effect of extreme obesity on mortality is greater among younger than older adults. In this respect, obesity is also associated with increased risk of several cancer types. However, up to 30% of obese patients are metabolically healthy with insulin sensitivity similar to healthy normal weight individuals, lower visceral fat content, and lower intima media thickness of the carotid artery than the majority of metabolically “unhealthy” obese patients.read more
Citations
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Journal ArticleDOI
Epidemiology, aetiology, and management of ischaemic stroke in young adults
Merel S. Ekker,Esther M. Boot,Aneesh B. Singhal,Kay Sin Tan,Stéphanie Debette,Anil M. Tuladhar,Frank-Erik de Leeuw +6 more
TL;DR: Progress has been made in identifying patients with a considerable risk of stroke occurrence, such as those with patent foramen ovale, and future prevention studies might result in a decrease in the incidence of stroke and its sequelae in young adults.
Journal ArticleDOI
Multimorbidity Trends in United States Adults, 1988-2014.
TL;DR: Multimorbidity is common and has been increasing over the last 25 years, which has implications for public health policy and anticipated health costs for the coming years.
Journal ArticleDOI
Dietary polyphenols to combat the metabolic diseases via altering gut microbiota
TL;DR: Although, there are numerous studies defines the effective role of PPs against MD via altering the GM, a significant research effort is still needed to consider PPs as promising nutraceuticals against MD.
Journal ArticleDOI
Curcumin, Quercetin, Catechins and Metabolic Diseases: The Role of Gut Microbiota.
Umair Shabbir,Momna Rubab,Eric Banan-Mwine Daliri,Ramachandran Chelliah,Ahsan Javed,Deog-Hwan Oh +5 more
TL;DR: In this article, the structural changes that occur after metabolic reactions in polyphenols (curcumin, quercetin, and catechins) and their effect on GM composition were investigated.
Journal ArticleDOI
The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action.
Bahare Salehi,Javad Sharifi-Rad,Francesca Cappellini,Željko Reiner,Debora Zorzan,Muhammad Imran,Bilge Sener,Mehtap Kilic,Mohamed El-Shazly,Mohamed El-Shazly,Nouran M. Fahmy,Eman Al-Sayed,Miquel Martorell,Chiara Tonelli,Katia Petroni,Anca Oana Docea,Daniela Calina,Alfred Maroyi +17 more
TL;DR: An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.
References
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Journal ArticleDOI
Body adiposity index and other indexes of body composition in the SAPHIR study: association with cardiovascular risk factors.
Andreas Melmer,Claudia Lamina,Alexander Tschoner,Claudia Ress,Susanne Kaser,Markus Laimer,A. Sandhofer,B. Paulweber,Christoph Ebenbichler +8 more
TL;DR: The accuracy of anthropometric surrogate markers such as the body adiposity index (BAI) and other common indexes like the body mass index (BMI), waist‐to‐hip ratio (WHR) and waist-to‐height ratio ( WHtR) to predict metabolic sequelae is essential for its use in clinical practice.
Journal ArticleDOI
Life Years Lost and Lifetime Health Care Expenditures Associated With Diabetes in the U.S., National Health Interview Survey, 1997–2000
TL;DR: It is shown that diabetes is associated with large decreases in life expectancy and large increases in lifetime health care expenditures, with highest life expectancy being for the overweight.
Journal ArticleDOI
Waist-to-height ratio, waist circumference and BMI as indicators of percentage fat mass and cardiometabolic risk factors in children aged 3-7 years.
TL;DR: In young children,WHtR is not superior to WC or BMI in estimating BF%, nor is WHtR better correlated with cardiometabolic risk factors than WC or waist circumference in overweight/obese children.
Journal ArticleDOI
"The metabolic syndrome... is dead": These reports are an exaggeration
TL;DR: The concept that the metabolic syndrome is a consequence of obesity and insulin resistance, provides a useful "life-style changes" approach for prevention and treatment, and could be a useful additional contributor in estimation of global cardiovascular risk beyond age, high cholesterol or other standard risk factors.
Journal ArticleDOI
Metabolic syndrome and adipose tissue: new clinical aspects and therapeutic targets.
TL;DR: Findings reinforce the notion that reductions in visceral adipose tissue should be a primary aim of strategies designed to reduce health risks associated with metabolic syndrome.
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