Journal ArticleDOI
The Eighth Edition Lung Cancer Stage Classification
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TLDR
This paper summarizes the eighth edition of lung cancer stage classification, which is the worldwide standard as of January 1, 2017, based on a large global database, a sophisticated analysis, extensive internal validation as well as multiple assessments confirming generalizability.About:
This article is published in Chest.The article was published on 2017-01-01. It has received 987 citations till now. The article focuses on the topics: Cancer.read more
Citations
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MARCKSL1 promotes the proliferation, migration and invasion of lung adenocarcinoma cells.
Wenjun Liang,Ruichen Gao,Mingxia Yang,Xiaohua Wang,Kewei Cheng,Xuejun Shi,Chen He,Yemei Li,Yuying Wu,Lei Shi,Jingtao Chen,Xiaowei Yu +11 more
TL;DR: The results obtained in the current study suggested that MARCKSL1 promoted the progression of lung adenocarcinoma by regulating EMT and may have prognostic value and serve as a novel therapeutic target in lungAdenocARCinoma.
Journal ArticleDOI
Validation of the Eighth Edition TNM Lung Cancer Staging System
Joseph Hwang,Barbara J. Page,David Flynn,Linda Passmore,Elizabeth McCaul,Jaccalyne Brady,Ian A. Yang,Henry M. Marshall,Morgan Windsor,Rayleen V. Bowman,Rishendran Naidoo,Tracey Guan,Shoni Philpot,Michael Blake,Kwun M. Fong +14 more
TL;DR: The authors' external validation study confirms the prognostic accuracy of the 8th edition TNM lung cancer classification and demonstrates that IIIB, IIIC and IVA stage groups showed similar survival outcomes, and suggests further research for refinement.
Journal ArticleDOI
PD-L1 Expression on Lung Cancer Stem Cells in Metastatic Lymph Nodes Aspirates.
TL;DR: The presence of CSCs with expression of PD-L1 in the metastatic LNs might suggest their immunogenic potential, and EBUS/TBNA is commonly used in diagnosis and staging of lung cancer, so the analysis of the cells in metastaticLNs may fit in “immunoscoring” before immunotherapy.
Journal ArticleDOI
Nivolumab-induced Myocarditis Successfully Treated with Corticosteroid Therapy: A Case Report and Review of the Literature
Keisuke Matsuo,Takashi Ishiguro,Takatomo Najama,Yoshihiko Shimizu,Yasuhito Kobayashi,Makoto Mutou +5 more
TL;DR: Although nivolumab-induced myocarditis is rare, cardiologists should consider it when encountering patients treated with such a drug for malignant disease.
Journal ArticleDOI
Cancer/testis antigens (CTAs) expression in resected lung cancer.
Shi Jin,Shoubo Cao,Jianhua Li,Qingwei Meng,Chunyan Wang,Lei Yao,Yaoguo Lang,Jingyan Cao,Jing Shen,Bo Pan,Jing Hu,Yan Yu +11 more
TL;DR: CTAs represent potential candidate targets for immunotherapy and their expression was closely correlated with tumor stage and high CTAG1B expression was an independent negative prognostic factor of lung ADC.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
BookDOI
TNM classification of malignant tumours
TL;DR: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.' Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumour .
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours.
Peter Goldstraw,John Crowley,Kari Chansky,Dorothy J. Giroux,Patti A. Groome,Ramón Rami-Porta,Pieter E. Postmus,Valerie W. Rusch,Leslie H. Sobin +8 more
TL;DR: Suggestions include additional cutoffs for tumor size, with tumors >7 cm moving from T2 to T3; reassigning the category given to additional pulmonary nodules in some locations; and reclassifying pleural effusion as an M descriptor.
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer.
Peter Goldstraw,Kari Chansky,John Crowley,Ramón Rami-Porta,Hisao Asamura,Wilfried Ernst Erich Eberhardt,Andrew G. Nicholson,Patti A. Groome,Alan Mitchell,Vanessa Bolejack,David Ball,David G. Beer,Ricardo Beyruti,Frank C. Detterbeck,Wilfried Eberhardt,John G. Edwards,Françoise Galateau-Salle,Dorothy Giroux,Fergus V. Gleeson,James Huang,Catherine Kennedy,Jhingook Kim,Young Tae Kim,Laura Kingsbury,Haruhiko Kondo,Mark Krasnik,Kaoru Kubota,Antoon Lerut,Gustavo Lyons,Mirella Marino,Edith M. Marom,Jan P. van Meerbeeck,Takashi Nakano,Anna K. Nowak,Michael D Peake,Thomas W. Rice,Kenneth E. Rosenzweig,Enrico Ruffini,Valerie W. Rusch,Nagahiro Saijo,Paul Van Schil,Jean-Paul Sculier,Lynn Shemanski,Kelly G. Stratton,Kenji Suzuki,Yuji Tachimori,Charles F. Thomas,William D. Travis,Ming-Sound Tsao,Andrew T. Turrisi,Johan Vansteenkiste,Hirokazu Watanabe,Yi-Long Wu,Paul Baas,Jeremy J. Erasmus,Seiki Hasegawa,Kouki Inai,Kemp H. Kernstine,Hedy L. Kindler,Lee M. Krug,Kristiaan Nackaerts,Harvey I. Pass,David C. Rice,Conrad Falkson,Pier Luigi Filosso,Giuseppe Giaccone,Kazuya Kondo,Marco Lucchi,Meinoshin Okumura,Eugene H. Blackstone,F. Abad Cavaco,E. Ansótegui Barrera,J. Abal Arca,I. Parente Lamelas,A. Arnau Obrer,R. Guijarro Jorge,D. Ball,G.K. Bascom,A. I. Blanco Orozco,M. A. González Castro,M.G. Blum,D. Chimondeguy,V. Cvijanovic,S. Defranchi,B. de Olaiz Navarro,I. Escobar Campuzano,I. Macía Vidueira,E. Fernández Araujo,F. Andreo García,Kwun M. Fong,G. Francisco Corral,S. Cerezo González,J. Freixinet Gilart,L. García Arangüena,S. García Barajas,P. Girard,Tuncay Göksel,M. T. González Budiño,G. González Casaurrán,J. A. Gullón Blanco,J. Hernández Hernández,H. Hernández Rodríguez,J. Herrero Collantes,M. Iglesias Heras,J. M. Izquierdo Elena,Erik Jakobsen,S. Kostas,P. León Atance,A. Núñez Ares,M. Liao,M. Losanovscky,G. Lyons,R. Magaroles,L. De Esteban Júlvez,M. Mariñán Gorospe,Brian C. McCaughan,Catherine J. Kennedy,R. Melchor Íñiguez,L. Miravet Sorribes,S. Naranjo Gozalo,C. Álvarez de Arriba,M. Núñez Delgado,J. Padilla Alarcón,J. C. Peñalver Cuesta,Jongsun Park,H. Pass,M. J. Pavón Fernández,Mara Rosenberg,Enrico Ruffini,V. Rusch,J. Sánchez de Cos Escuín,A. Saura Vinuesa,M. Serra Mitjans,Trond Eirik Strand,Dragan Subotic,S.G. Swisher,Ricardo Mingarini Terra,Charles R. Thomas,Kurt G. Tournoy,P. Van Schil,M. Velasquez,Y.L. Wu,K. Yokoi +142 more
TL;DR: The methods used to evaluate the resultant Stage groupings and the proposals put forward for the 8th edition of the TNM Classification for lung cancer due to be published late 2016 are described.
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Ramón Rami-Porta,David Ball,John Crowley,Dorothy J. Giroux,James R. Jett,William D. Travis,Masahiro Tsuboi,Eric Vallières,Peter Goldstraw +8 more
TL;DR: Recommendations are to subclassify T1 into T1a, T1b, and T1c, and to group involvement of main bronchus as T2 regardless of distance from carina; to group partial and total atelectasis/pneumonitis as T1; to reclassify diaphragm invasion as T4; and to delete mediastinal pleura invasion as a T descriptor.
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