Journal ArticleDOI
The Eighth Edition Lung Cancer Stage Classification
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TLDR
This paper summarizes the eighth edition of lung cancer stage classification, which is the worldwide standard as of January 1, 2017, based on a large global database, a sophisticated analysis, extensive internal validation as well as multiple assessments confirming generalizability.About:
This article is published in Chest.The article was published on 2017-01-01. It has received 987 citations till now. The article focuses on the topics: Cancer.read more
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Prognostic analysis of patients with mutant and wild-type EGFR gene lung adenocarcinoma
Hongmei Zheng,Yuting Zhang,Yuting Zhan,Sile Liu,Junmi Lu,Juan Feng,Xia Wu,Qiuyuan Wen,Songqing Fan +8 more
TL;DR: Investigation of the relationship between epidermal growth factor receptor (EGFR) gene mutation and clinicopathological features of lung adenocarcinoma, and the prognostic and therapeutic value of EGFR found EGFR-TKI treatment was an independent positive predictor in patients with EGFR gene mutation.
Journal ArticleDOI
PD-L1+ lung cancer stem cells modify the metastatic lymph-node immunomicroenvironment in nsclc patients.
Agata Raniszewska,Heleen Vroman,Daphne W. Dumoulin,Robin Cornelissen,Joachim G.J.V. Aerts,Joanna Domagała-Kulawik +5 more
TL;DR: The frequency of PD-L1 + CSCs associates with an altered T-cell frequency and phenotype indicating that C SCs can affect the immune system, and may be an interesting target for immunotherapy.
Journal ArticleDOI
Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance)
Raphael Bueno,William G. Richards,David H. Harpole,Karla V. Ballman,Ming-Sound Tsao,Zhengming Chen,Xiaofei Wang,Guoan Chen,Lucian R. Chirieac,M. Herman Chui,Wilbur A. Franklin,Thomas J. Giordano,Ramaswamy Govindan,Mary Beth Joshi,Daniel T. Merrick,Christopher J. Rivard,Thomas A. Sporn,Adrie van Bokhoven,Hui Yu,Frances A. Shepherd,Mark A. Watson,David G. Beer,Fred R. Hirsch,Fred R. Hirsch +23 more
TL;DR: These results represent the first rigorous validation of a test appropriate to direct adjuvant treatment or clinical trials for patients with lung squamous cell carcinoma.
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Enhanced recovery after surgery: adherence and outcomes in elderly patients undergoing VATS lobectomy.
Federico Mazza,Massimiliano Venturino,Davide Turello,Alberto Gorla,Cristina Degiovanni,Giuseppina Gambera,Alessandro Locatelli,Giulio Melloni +7 more
TL;DR: Elderly patients adhere to an ERAS protocol similarly to younger ones, age did not significantly influence LoS, and ERAS pathway in VATS lobectomy patients seems to be beneficial regardless of age.
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Machine learning application in personalised lung cancer recurrence and survivability prediction
TL;DR: In this paper , the authors integrate genomic, clinical and demographic data of lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) patients from The Cancer Genome Atlas (TCGA) and introduce copy number variation (CNV) and mutation information of 15 selected genes to generate predictive models for recurrence and survivability.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
BookDOI
TNM classification of malignant tumours
TL;DR: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.' Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumour .
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours.
Peter Goldstraw,John Crowley,Kari Chansky,Dorothy J. Giroux,Patti A. Groome,Ramón Rami-Porta,Pieter E. Postmus,Valerie W. Rusch,Leslie H. Sobin +8 more
TL;DR: Suggestions include additional cutoffs for tumor size, with tumors >7 cm moving from T2 to T3; reassigning the category given to additional pulmonary nodules in some locations; and reclassifying pleural effusion as an M descriptor.
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer.
Peter Goldstraw,Kari Chansky,John Crowley,Ramón Rami-Porta,Hisao Asamura,Wilfried Ernst Erich Eberhardt,Andrew G. Nicholson,Patti A. Groome,Alan Mitchell,Vanessa Bolejack,David Ball,David G. Beer,Ricardo Beyruti,Frank C. Detterbeck,Wilfried Eberhardt,John G. Edwards,Françoise Galateau-Salle,Dorothy Giroux,Fergus V. Gleeson,James Huang,Catherine Kennedy,Jhingook Kim,Young Tae Kim,Laura Kingsbury,Haruhiko Kondo,Mark Krasnik,Kaoru Kubota,Antoon Lerut,Gustavo Lyons,Mirella Marino,Edith M. Marom,Jan P. van Meerbeeck,Takashi Nakano,Anna K. Nowak,Michael D Peake,Thomas W. Rice,Kenneth E. Rosenzweig,Enrico Ruffini,Valerie W. Rusch,Nagahiro Saijo,Paul Van Schil,Jean-Paul Sculier,Lynn Shemanski,Kelly G. Stratton,Kenji Suzuki,Yuji Tachimori,Charles F. Thomas,William D. Travis,Ming-Sound Tsao,Andrew T. Turrisi,Johan Vansteenkiste,Hirokazu Watanabe,Yi-Long Wu,Paul Baas,Jeremy J. Erasmus,Seiki Hasegawa,Kouki Inai,Kemp H. Kernstine,Hedy L. Kindler,Lee M. Krug,Kristiaan Nackaerts,Harvey I. Pass,David C. Rice,Conrad Falkson,Pier Luigi Filosso,Giuseppe Giaccone,Kazuya Kondo,Marco Lucchi,Meinoshin Okumura,Eugene H. Blackstone,F. Abad Cavaco,E. Ansótegui Barrera,J. Abal Arca,I. Parente Lamelas,A. Arnau Obrer,R. Guijarro Jorge,D. Ball,G.K. Bascom,A. I. Blanco Orozco,M. A. González Castro,M.G. Blum,D. Chimondeguy,V. Cvijanovic,S. Defranchi,B. de Olaiz Navarro,I. Escobar Campuzano,I. Macía Vidueira,E. Fernández Araujo,F. Andreo García,Kwun M. Fong,G. Francisco Corral,S. Cerezo González,J. Freixinet Gilart,L. García Arangüena,S. García Barajas,P. Girard,Tuncay Göksel,M. T. González Budiño,G. González Casaurrán,J. A. Gullón Blanco,J. Hernández Hernández,H. Hernández Rodríguez,J. Herrero Collantes,M. Iglesias Heras,J. M. Izquierdo Elena,Erik Jakobsen,S. Kostas,P. León Atance,A. Núñez Ares,M. Liao,M. Losanovscky,G. Lyons,R. Magaroles,L. De Esteban Júlvez,M. Mariñán Gorospe,Brian C. McCaughan,Catherine J. Kennedy,R. Melchor Íñiguez,L. Miravet Sorribes,S. Naranjo Gozalo,C. Álvarez de Arriba,M. Núñez Delgado,J. Padilla Alarcón,J. C. Peñalver Cuesta,Jongsun Park,H. Pass,M. J. Pavón Fernández,Mara Rosenberg,Enrico Ruffini,V. Rusch,J. Sánchez de Cos Escuín,A. Saura Vinuesa,M. Serra Mitjans,Trond Eirik Strand,Dragan Subotic,S.G. Swisher,Ricardo Mingarini Terra,Charles R. Thomas,Kurt G. Tournoy,P. Van Schil,M. Velasquez,Y.L. Wu,K. Yokoi +142 more
TL;DR: The methods used to evaluate the resultant Stage groupings and the proposals put forward for the 8th edition of the TNM Classification for lung cancer due to be published late 2016 are described.
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Ramón Rami-Porta,David Ball,John Crowley,Dorothy J. Giroux,James R. Jett,William D. Travis,Masahiro Tsuboi,Eric Vallières,Peter Goldstraw +8 more
TL;DR: Recommendations are to subclassify T1 into T1a, T1b, and T1c, and to group involvement of main bronchus as T2 regardless of distance from carina; to group partial and total atelectasis/pneumonitis as T1; to reclassify diaphragm invasion as T4; and to delete mediastinal pleura invasion as a T descriptor.
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