Journal ArticleDOI
The Eighth Edition Lung Cancer Stage Classification
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TLDR
This paper summarizes the eighth edition of lung cancer stage classification, which is the worldwide standard as of January 1, 2017, based on a large global database, a sophisticated analysis, extensive internal validation as well as multiple assessments confirming generalizability.About:
This article is published in Chest.The article was published on 2017-01-01. It has received 987 citations till now. The article focuses on the topics: Cancer.read more
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Durvalumab for Stage III EGFR-Mutated NSCLC After Definitive Chemoradiotherapy.
Jacqueline V. Aredo,Isa Mambetsariev,Jessica A. Hellyer,Arya Amini,Joel W. Neal,Sukhmani K. Padda,Caroline E. McCoach,Jonathan W. Riess,Elwyn Cabebe,Jarushka Naidoo,T. Abuali,Ravi Salgia,Billy W. Loo,Maximilian Diehn,Summer S. Han,Heather A. Wakelee +15 more
TL;DR: In this paper, the authors conducted a multi-institutional retrospective analysis of patients with stage III EGFR-mutated NSCLC who completed concurrent chemoradiotherapy (CRT) and found that concurrent CRT with induction or consolidation EGFR tyrosine kinase inhibitors (TKIs) was associated with a significantly longer median PFS.
Posted ContentDOI
A mathematical model of ctDNA shedding predicts tumor detection size
Stefano Avanzini,David M. Kurtz,Jacob J. Chabon,Sharon S. Hori,Sanjiv S. Gambhir,Ash A. Alizadeh,Maximilian Diehn,Johannes G. Reiter +7 more
TL;DR: A stochastic mathematical model of tumor evolution and circulating tumor DNA (ctDNA) shedding is developed to determine the potential and the limitations of cancer early detection tests and can help to optimize early cancer detection approaches.
Journal ArticleDOI
MicroRNAs in non-small cell lung cancer: Gene regulation, impact on cancer cellular processes, and therapeutic potential.
Hannah Petrek,Aiming Yu +1 more
TL;DR: By illustrating the roles of miRNAs in the control of NSCLC tumorigenesis and progression, this article highlights the latest efforts in assessing miRNA‐based therapies in animal models and discusses some critical challenges in developing RNA therapeutics.
Journal ArticleDOI
Liquid Biopsy for Cancer: Review and Implications for the Radiologist
Jacob Underwood,Rehan Quadri,Sanjeeva P. Kalva,Hriday Shah,Aravind Sanjeevaiah,Muhammad Shaalan Beg,Patrick D. Sutphin +6 more
TL;DR: The liquid biopsy is currently used clinically for therapeutic guidance when tissue acquisition is impossible or when the specimen is inadequate and is also being studied in the context of screening, diagnosis, and surveillance.
Journal ArticleDOI
Improved diagnostic yield for lung nodules with digital tomosynthesis‐corrected navigational bronchoscopy: Initial experience with a novel adjunct
Matt Aboudara,Lance Roller,Otis B. Rickman,Robert J. Lentz,Jasleen Pannu,Heidi Chen,Fabien Maldonado +6 more
TL;DR: A retrospective review of ENB cases at an institution before and after introduction of F‐ENB to assess diagnostic yield found it inferior to that of computed tomography‐guided needle biopsy for pulmonary nodules.
References
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Book
AJCC Cancer Staging Manual
Mahul B. Amin,Stephen B. Edge,Frederick L. Greene,David R. Byrd,Robert K. Brookland,Mary Kay Washington,Jeffrey E. Gershenwald,Carolyn C. Compton,Kenneth R. Hess,Daniel C. Sullivan,J. Milburn Jessup,James D. Brierley,Lauri E. Gaspar,Richard L. Schilsky,Charles M. Balch,David P. Winchester,Elliot A. Asare,Martin Madera,Donna M. Gress,Laura R. Meyer +19 more
TL;DR: Purposes and Principles of Cancer Staging and End-Results Reporting are explained.
BookDOI
TNM classification of malignant tumours
TL;DR: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.' Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumour .
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours.
Peter Goldstraw,John Crowley,Kari Chansky,Dorothy J. Giroux,Patti A. Groome,Ramón Rami-Porta,Pieter E. Postmus,Valerie W. Rusch,Leslie H. Sobin +8 more
TL;DR: Suggestions include additional cutoffs for tumor size, with tumors >7 cm moving from T2 to T3; reassigning the category given to additional pulmonary nodules in some locations; and reclassifying pleural effusion as an M descriptor.
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer.
Peter Goldstraw,Kari Chansky,John Crowley,Ramón Rami-Porta,Hisao Asamura,Wilfried Ernst Erich Eberhardt,Andrew G. Nicholson,Patti A. Groome,Alan Mitchell,Vanessa Bolejack,David Ball,David G. Beer,Ricardo Beyruti,Frank C. Detterbeck,Wilfried Eberhardt,John G. Edwards,Françoise Galateau-Salle,Dorothy Giroux,Fergus V. Gleeson,James Huang,Catherine Kennedy,Jhingook Kim,Young Tae Kim,Laura Kingsbury,Haruhiko Kondo,Mark Krasnik,Kaoru Kubota,Antoon Lerut,Gustavo Lyons,Mirella Marino,Edith M. Marom,Jan P. van Meerbeeck,Takashi Nakano,Anna K. Nowak,Michael D Peake,Thomas W. Rice,Kenneth E. Rosenzweig,Enrico Ruffini,Valerie W. Rusch,Nagahiro Saijo,Paul Van Schil,Jean-Paul Sculier,Lynn Shemanski,Kelly G. Stratton,Kenji Suzuki,Yuji Tachimori,Charles F. Thomas,William D. Travis,Ming-Sound Tsao,Andrew T. Turrisi,Johan Vansteenkiste,Hirokazu Watanabe,Yi-Long Wu,Paul Baas,Jeremy J. Erasmus,Seiki Hasegawa,Kouki Inai,Kemp H. Kernstine,Hedy L. Kindler,Lee M. Krug,Kristiaan Nackaerts,Harvey I. Pass,David C. Rice,Conrad Falkson,Pier Luigi Filosso,Giuseppe Giaccone,Kazuya Kondo,Marco Lucchi,Meinoshin Okumura,Eugene H. Blackstone,F. Abad Cavaco,E. Ansótegui Barrera,J. Abal Arca,I. Parente Lamelas,A. Arnau Obrer,R. Guijarro Jorge,D. Ball,G.K. Bascom,A. I. Blanco Orozco,M. A. González Castro,M.G. Blum,D. Chimondeguy,V. Cvijanovic,S. Defranchi,B. de Olaiz Navarro,I. Escobar Campuzano,I. Macía Vidueira,E. Fernández Araujo,F. Andreo García,Kwun M. Fong,G. Francisco Corral,S. Cerezo González,J. Freixinet Gilart,L. García Arangüena,S. García Barajas,P. Girard,Tuncay Göksel,M. T. González Budiño,G. González Casaurrán,J. A. Gullón Blanco,J. Hernández Hernández,H. Hernández Rodríguez,J. Herrero Collantes,M. Iglesias Heras,J. M. Izquierdo Elena,Erik Jakobsen,S. Kostas,P. León Atance,A. Núñez Ares,M. Liao,M. Losanovscky,G. Lyons,R. Magaroles,L. De Esteban Júlvez,M. Mariñán Gorospe,Brian C. McCaughan,Catherine J. Kennedy,R. Melchor Íñiguez,L. Miravet Sorribes,S. Naranjo Gozalo,C. Álvarez de Arriba,M. Núñez Delgado,J. Padilla Alarcón,J. C. Peñalver Cuesta,Jongsun Park,H. Pass,M. J. Pavón Fernández,Mara Rosenberg,Enrico Ruffini,V. Rusch,J. Sánchez de Cos Escuín,A. Saura Vinuesa,M. Serra Mitjans,Trond Eirik Strand,Dragan Subotic,S.G. Swisher,Ricardo Mingarini Terra,Charles R. Thomas,Kurt G. Tournoy,P. Van Schil,M. Velasquez,Y.L. Wu,K. Yokoi +142 more
TL;DR: The methods used to evaluate the resultant Stage groupings and the proposals put forward for the 8th edition of the TNM Classification for lung cancer due to be published late 2016 are described.
Journal ArticleDOI
The IASLC Lung Cancer Staging Project: Proposals for the Revisions of the T Descriptors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Ramón Rami-Porta,David Ball,John Crowley,Dorothy J. Giroux,James R. Jett,William D. Travis,Masahiro Tsuboi,Eric Vallières,Peter Goldstraw +8 more
TL;DR: Recommendations are to subclassify T1 into T1a, T1b, and T1c, and to group involvement of main bronchus as T2 regardless of distance from carina; to group partial and total atelectasis/pneumonitis as T1; to reclassify diaphragm invasion as T4; and to delete mediastinal pleura invasion as a T descriptor.
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