The extracellular matrix: A dynamic niche in cancer progression
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TLDR
The extracellular matrix (ECM), a complex network of macromolecules with distinctive physical, biochemical, and biomechanical properties, is commonly deregulated and becomes disorganized in diseases such as cancer.Abstract:
The local microenvironment, or niche, of a cancer cell plays important roles in cancer development. A major component of the niche is the extracellular matrix (ECM), a complex network of macromolecules with distinctive physical, biochemical, and biomechanical properties. Although tightly controlled during embryonic development and organ homeostasis, the ECM is commonly deregulated and becomes disorganized in diseases such as cancer. Abnormal ECM affects cancer progression by directly promoting cellular transformation and metastasis. Importantly, however, ECM anomalies also deregulate behavior of stromal cells, facilitate tumor-associated angiogenesis and inflammation, and thus lead to generation of a tumorigenic microenvironment. Understanding how ECM composition and topography are maintained and how their deregulation influences cancer progression may help develop new therapeutic interventions by targeting the tumor niche.read more
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Remodelling the extracellular matrix in development and disease.
TL;DR: The extracellular matrix is crucial for regulating the morphogenesis of the intestine and lungs, as well as of the mammary and submandibular glands, and its regulation contributes to several pathological conditions, such as fibrosis and invasive cancer.
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Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
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Extracellular matrix structure.
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Preterm labor: One syndrome, many causes
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The extracellular matrix modulates the hallmarks of cancer
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References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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