The Hippo Pathway, YAP/TAZ and the Plasma Membrane
Reads0
Chats0
TLDR
Morphologically defined structures within the plasma membrane, such as cellular junctions, focal adhesions, primary cilia, caveolae, clathrin-coated pits, and plaques play additional key roles in cellular feedback via the Hippo pathway.About:
This article is published in Trends in Cell Biology.The article was published on 2020-01-01 and is currently open access. It has received 133 citations till now. The article focuses on the topics: Hippo signaling pathway & Caveolae.read more
Citations
More filters
Journal ArticleDOI
The myofibroblast at a glance.
Pardis Pakshir,Nina Noskovičová,Monika Lodyga,Dong Ok Son,Ronen Schuster,Amanda Goodwin,Henna Karvonen,Henna Karvonen,Boris Hinz +8 more
TL;DR: An overview of the current understanding of central aspects of myofibroblast biology, such as their definition, activation from different precursors, the involved signaling pathways and most widely used models to study their function, is provided.
Journal ArticleDOI
Mechanobiology of the brain in ageing and Alzheimer's disease.
TL;DR: The complex and inhomogeneous mechanical structure of CNS tissue, as revealed by recent mechanical measurements on the brain and spinal cord, is discussed using techniques such as magnetic resonance elastography and atomic force microscopy.
Journal ArticleDOI
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
TL;DR: The Hippo pathway plays an integral role in both tumour suppressive and oncogenic processes, generally via regulation of a diverse set of genes involved in a range of biological functions as discussed by the authors .
Journal ArticleDOI
Atherosclerosis: Insights into Vascular Pathobiology and Outlook to Novel Treatments.
Marc P. Wolf,Patrick Hunziker +1 more
TL;DR: The pathobiology of atherosclerosis and its current and potential future treatments are summarized, with a spotlight on three central cell types involved: endothelial cells, macrophages, and vascular smooth muscle cells.
Journal ArticleDOI
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.
Isabel Pablos,Yoan Machado,Hugo C. Ramos de Jesus,Yasir Mohamud,Yasir Mohamud,Reinhild Kappelhoff,Cecilia Lindskog,Marli Vlok,Peter A. Bell,Georgina S. Butler,Peter M. Grin,Quynh T. Cao,Jenny P. Nguyen,Nestor Solis,Srinivas Abbina,Wioletta Rut,John C. Vederas,Laszlo Szekely,Attila Szakos,Marcin Drag,Jayachandran N. Kizhakkedathu,Karen L. Mossman,Jeremy A. Hirota,Eric Jan,Honglin Luo,Honglin Luo,Arinjay Banerjee,Christopher M. Overall +27 more
TL;DR: In this paper, the authors delineate the human protein substrate landscape of 3CLpro by TAILS substrate-targeted N-terminomics and identify more than 100 substrates in human lung and kidney cells supported by analyses of SARS-CoV-2-infected cells.
References
More filters
Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
Journal ArticleDOI
Cell Movement Is Guided by the Rigidity of the Substrate
TL;DR: It is discovered that changes in tissue rigidity and strain could play an important controlling role in a number of normal and pathological processes involving cell locomotion, including morphogenesis, the immune response, and wound healing.
Journal ArticleDOI
Flow-mediated endothelial mechanotransduction
TL;DR: The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.
Journal ArticleDOI
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
Bin Zhao,Xiaomu Wei,Weiquan Li,Ryan S. Udan,Ryan S. Udan,Qian Yang,Joungmok Kim,Joungmok Kim,Joe Xie,Tsuneo Ikenoue,Jindan Yu,Li Li,Li Li,Pan Zheng,Keqiang Ye,Arul M. Chinnaiyan,Georg Halder,Georg Halder,Zhi Chun Lai,Kun-Liang Guan,Kun-Liang Guan +20 more
TL;DR: It is demonstrated that in mammalian cells, the transcription coactivator YAP (Yes-associated protein), is inhibited by cell density via the Hippo pathway, and YAP overexpression regulates gene expression in a manner opposite to cell density, and is able to overcome cell contact inhibition.
Journal ArticleDOI
TEAD mediates YAP-dependent gene induction and growth control
Bin Zhao,Xin Ye,Jindan Yu,Li Li,Li Li,Weiquan Li,Siming Li,Jianjun Yu,Jiandie D. Lin,Cun-Yu Wang,Arul M. Chinnaiyan,Zhi Chun Lai,Kun-Liang Guan +12 more
TL;DR: TEAD is revealed as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP, and is required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition.