Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
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Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.
Payam Nahid,Susan E. Dorman,Narges Alipanah,Pennan M. Barry,Jan Brozek,Adithya Cattamanchi,Lelia H. Chaisson,Richard E. Chaisson,Charles L. Daley,M. Grzemska,Julie Higashi,Christine S Ho,Philip C. Hopewell,Salmaan Keshavjee,Christian Lienhardt,Richard Menzies,Cynthia Merrifield,Masahiro Narita,Rick O'Brien,Charles A. Peloquin,Ann Raftery,Jussi J. Saukkonen,H. Simon Schaaf,Giovanni Sotgiu,Jeffrey R. Starke,Giovanni Battista Migliori,Andrew Vernon +26 more
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Inflammation in AKI: Current Understanding, Key Questions, and Knowledge Gaps
Hamid Rabb,Matthew D. Griffin,Dianne B. McKay,Sundararaman Swaminathan,Peter Pickkers,Mitchell H. Rosner,John A. Kellum,Claudio Ronco +7 more
TL;DR: The most important recent developments in understanding the inflammatory mechanisms of AKI are summarized, key limitations of the commonly used animal models and clinical trial designs that may prevent successful clinical application are highlighted, and priority approaches for research toward clinical translation are suggested.
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Complement in disease: a defence system turning offensive
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Immune cells in experimental acute kidney injury
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TL;DR: Experimental studies of immune cells in AKI have resulted in improved understanding of the immune mechanisms underlying AKI and will be the foundation for development of novel diagnostic and therapeutic targets.
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References
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Journal ArticleDOI
Participation of cell-mediated immunity in deposition of fibrin in glomerulonephritis.
T. J. Neale,T. J. Neale,Steven D Carson,Steven D Carson,P. G. Tipping,P. G. Tipping,S. R. Holdsworth,S. R. Holdsworth +7 more
TL;DR: All the essential elements of DTH reactions can be simultaneously demonstrated within glomeruli from patients with fibrin-related GN and suggest a role for cell mediated immunity in GN.
Quantification of dendritic cell subsets in human renal tissue under normal and pathological
TL;DR: In this article, a detailed analysis of myeloid and plasmacytoid Dendritic Cells (DCs) subsets in human renal tissue is presented. But no accurate estimates of DC subsets have been reported.
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Anti–LAMP-2 Antibodies Are Not Prevalent in Patients With Antineutrophil Cytoplasmic Autoantibody Glomerulonephritis
Aleeza J. Roth,Michael C. Brown,Rex Neal Smith,Anshul K. Badhwar,Oscar Parente,Hyun Chul Chung,Donna O. Bunch,Julie Anne G. McGregor,Susan L. Hogan,Yichun Hu,Jia Jin Yang,Elisabeth A. Berg,John L. Niles,J. Charles Jennette,Gloria A. Preston,Ronald J. Falk +15 more
TL;DR: In conclusion, antibodies that react with LAMP-2 may exist at very low titers in a minority of patients with ANCA disease, and data do not support a mechanistic relationship between anti-Lamp-2 antibodies and ANCA glomerulonephritis.
Journal ArticleDOI
Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions
Andrea M. Woltman,J.W. de Fijter,Kim Zuidwijk,A.G. Vlug,Ingeborg M. Bajema,S. W. Van Der Kooij,V van Ham,C. van Kooten +7 more
TL;DR: It is shown that human kidneys contain a dense network of myeloid and plasmacytoid DCs and the tools for phenotyping and enumeration of these cells to better understand interindividual differences in immune responses are provided.
Journal ArticleDOI
Renal cell–expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis
TL;DR: TNF is essential for the development of glomerulonephritis, an immune-mediated disorder that is a major cause of renal failure worldwide, but TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2.