Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
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Properdin-dependent activation and control of immune-homeostasis and autoimmunity
TL;DR: The complement system has been shown to have a role in various systemic autoimmune diseases which have a renal component, with the exact mechanism of how these SLE autoantigens along with their autoantibodies interact with complement in the glomerulus remaining ambiguous.
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Triple hit to the kidney-dual pathological crescentic glomerulonephritis and diffuse proliferative immune complex-mediated glomerulonephritis: A case report
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Editorial: Innovative Biologics and Drugs to Target Renal Inflammation.
TL;DR: The goal of this Research Topic was to highlight recent basic, pre-clinical, and clinical progress and opportunities related to the targeting of renal inflammation using drugs and biologic agents by publishing relevant full-length and short original research communications and review articles.
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A grain of salt on kidney dendritic cell function in allograft rejection
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Journal ArticleDOI
Capacidad de respuesta inmunitaria al COVID-19 en pacientes en hemodiálisis
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TL;DR: In this article, a study of 69 patients with enfermedad renal cronica en hemodialisis tienen una respuesta inmune humoral alterada and una baja respusesta de seroconversion a vacunas.
References
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TL;DR: The main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies.
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Journal ArticleDOI
Cellular pathophysiology of ischemic acute kidney injury
Joseph V. Bonventre,Li Yang +1 more
TL;DR: The major components of this dynamic process, which involves hemodynamic alterations, inflammation, and endothelial and epithelial cell injury, followed by repair that can be adaptive and restore epithelial integrity or maladaptive, leading to chronic kidney disease are reviewed.
Journal ArticleDOI
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Journal ArticleDOI
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