Journal ArticleDOI
The immune system and kidney disease: basic concepts and clinical implications
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TLDR
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease.Abstract:
The kidneys are frequently targeted by pathogenic immune responses against renal autoantigens or by local manifestations of systemic autoimmunity. Recent studies in rodent models and humans have uncovered several underlying mechanisms that can be used to explain the previously enigmatic immunopathology of many kidney diseases. These mechanisms include kidney-specific damage-associated molecular patterns that cause sterile inflammation, the crosstalk between renal dendritic cells and T cells, the development of kidney-targeting autoantibodies and molecular mimicry with microbial pathogens. Conversely, kidney failure affects general immunity, causing intestinal barrier dysfunction, systemic inflammation and immunodeficiency that contribute to the morbidity and mortality of patients with kidney disease. In this Review, we summarize the recent findings regarding the interactions between the kidneys and the immune system.read more
Citations
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Journal ArticleDOI
Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction
Calen P. Ryan,Meaghan J. Jones,Rachel D. Edgar,Nanette R. Lee,Michael S. Kobor,Thomas W. McDade,Christopher W. Kuzawa +6 more
TL;DR: Differences in immune cell composition and gene regulation during pregnancy and breastfeeding are reported, suggesting mechanisms for female CoR.
Book ChapterDOI
Inflammation in Nonimmune-Mediated Chronic Kidney Disease
TL;DR: This chapter provides an overview on inflammation and CKD development not related to autoimmunity or caused by presence of foreign antigens, and the mechanisms by which this process is activated and perpetuated.
Journal ArticleDOI
Kidney organoid systems for studies of immune-mediated kidney diseases: challenges and opportunities
TL;DR: In this paper, the role of the immune system in renal tissue development, regeneration, and inflammation was investigated using kidney organoid models, including pluripotent stem cell-derived kidney organoids and primary epithelial cell-based tubuloids.
Journal ArticleDOI
Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88.
Wenjuan Sun,Chang Hyun Byon,Dong-Hyun Kim,Hoon In Choi,Jung Sun Park,Soo Yeon Joo,In Jin Kim,Inae Jung,Eun Hui Bae,Seong Kwon Ma,Soo Wan Kim +10 more
TL;DR: Maslinic acid (MA) is a pentacyclic triterpene extracted from fruits and vegetables, which has been shown to attenuate renal fibrosis and determine the putative underlying molecular mechanisms as discussed by the authors.
Journal ArticleDOI
Serum markers of fibrosis, cardiovascular and all-cause mortality in hemodialysis patients: the AURORA trial.
Madonna Salib,Sophie Girerd,Nicolas Girerd,Winfried März,Hubert Scharnagl,Ziad A. Massy,Céline Leroy,Kevin Duarte,Hallvard Holdaas,Alan G. Jardine,Roland E. Schmieder,Bengt Fellström,Natalia López-Andrés,Patrick Rossignol,Faiez Zannad +14 more
TL;DR: In this paper, the authors investigated the relationship of the blood levels of two markers associated with fibrosis: procollagen type I C-terminal pro-peptide (PICP) and galectin-3 (Gal-3) with mortality in dialysis patients.
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